未登录 Scientific and Regulatory Policy Committee Points to Consider*: Sample Selection, Assay Design, Data Generation and Interpretation, and Reporting Practices for Chromogenic Immunohistochemical (IHC) Assays in Nonclinical Drug Development 科学和监管政策委员会考虑要点*: 样本选择、检测试剂盒设计、数据生成与解释以及报告实践，用于非临床药物开发中的显色免疫组织化学（IHC）检测试剂盒 Aeffner, Famke; Bolon, Brad; Boyle, Molly H.; Buetow, Bernard S.; Forest, Thomas; Janardhan, Kyathanahalli; Mansfield, Keith; Meyerholz, David K.; Price, Shari; Rebelatto, Marlon C. 分享 收藏
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Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein (Vol 15, 1345473, 2024) Kroenke, Mark A.; Manning, Marta Starcevic; Zuch de Zafra, Christina L.; Zhang, Xinwen; Cook, Kevin D.; Archer, Michael; Lolkema, Martijn P.; Wang, Jin; Hoofring, Sarah; Saini, Gurleen; Aeffner, Famke; Ahern, Elizabeth; Cabanas, Elena Garralda; Govindan, Ramaswamy; Hui, Mun; Gupta, Shalini; Mytych, Daniel T. 分享 收藏
Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein Kroenke, Mark A.; Starcevic Manning, Marta; Zuch de Zafra, Christina L.; Zhang, Xinwen; Cook, Kevin D.; Archer, Michael; Lolkema, Martijn P.; Wang, Jin; Hoofring, Sarah; Saini, Gurleen; Aeffner, Famke; Ahern, Elizabeth; Cabanas, Elena Garralda; Govindan, Ramaswamy; Hui, Mun; Gupta, Shalini; Mytych, Daniel T. 分享 收藏
Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis Magnusson, Magnus I.; Agnarsson, Bjarni A.; Jonasson, Jon G.; Tryggvason, Thordur; Aeffner, Famke; le Roux, Louise; Magnusdottir, Droplaug N.; Gunnarsdottir, Helga S.; Alexiusdottir, Kristin K.; Gunnarsdottir, Kristbjorg; Soeebech, Emilia; Runarsdottir, Hjaltey; Jonsdottir, Erna M.; Kristinsdottir, Bjarney S.; Olafsson, Sigurgeir; Knutsdottir, Hildur; Thorsteinsdottir, Unnur; Ulfarsson, Magnus O.; Gudbjartsson, Daniel F.; Saemundsdottir, Jona; Magnusson, Olafur T.; Norddahl, Gudmundur L.; Watson, J. E. Vivienne; Rafnar, Thorunn; Lund, Sigrun H.; Stefansson, Kari 分享 收藏
Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors 免疫疗法组合克服了T细胞冷实体瘤对双特异性T细胞衔接治疗的抵抗力 Belmontes, Brian; Sawant, Deepali, V; Zhong, Wendy; Tan, Hong; Kaul, Anupurna; Aeffner, Famke; O'Brien, Sarah A.; Chun, Matthew; Noubade, Rajkumar; Eng, Jason; Ma, Hayley; Muenz, Markus; Li, Peng; Alba, Benjamin M.; Thomas, Melissa; Cook, Kevin; Wang, Xiaoting; DeVoss, Jason; Egen, Jackson G.; Nolan-Stevaux, Olivier 分享 收藏
Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule Pham, Elizabeth; Friedrich, Matthias; Aeffner, Famke; Lutteropp, Michael; Mariano, Natalie F.; Deegen, Petra; Dahlhoff, Christoph; Vogel, Franziska; Bluemel, Claudia; Harrold, John M.; Brandl, Christian; Grinberg, Natalia; Rattel, Benno; Coxon, Angela; Bailis, Julie M. 分享 收藏
The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer Deegen, Petra; Thomas, Oliver; Nolan-Stevaux, Olivier; Li, Shyun; Wahl, Joachim; Bogner, Pamela; Aeffner, Famke; Friedrich, Matthias; Liao, Michael Z.; Matthes, Katja; Rau, Doris; Rattel, Benno; Raum, Tobias; Kufer, Peter; Coxon, Angela; Bailis, Julie M. 分享 收藏
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association 计算病理学定义，最佳实践和监管指导建议: 数字病理学协会的白皮书 Abels, Esther; Pantanowitz, Liron; Aeffner, Famke; Zarella, Mark D.; van der Laak, Jeroen; Bui, Marilyn M.; Vemuri, Venkata N. P.; Parwani, Anil V.; Gibbs, Jeff; Agosto-Arroyo, Emmanuel; Beck, Andrew H.; Kozlowski, Cleopatra 分享 收藏
Digital Microscopy, Image Analysis, and Virtual Slide Repository Aeffner, Famke; Adissu, Hibret A.; Boyle, Michael C.; Cardiff, Robert D.; Hagendorn, Erik; Hoenerhoff, Mark J.; Klopfleisch, Robert; Newbigging, Susan; Schaudien, Dirk; Turner, Oliver; Wilson, Kristin 分享 收藏
Validation of a Muscle-Specific Tissue Image Analysis Tool for Quantitative Assessment of Dystrophin Staining in Frozen Muscle Biopsies Aeffner, Famke; Faelan, Crystal; Moore, Steven A.; Moody, Alexander; Black, Joshua C.; Charleston, Jay S.; Frank, Diane E.; Dworzak, Johannes; Piper, I. Kris; Ranjitkar, Manish; Wilson, Kristin; Kanaly, Suzanne; Rudmann, Daniel G.; Lange, Holger; Young, G. David; Milici, Anthony, I 分享 收藏
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Quantifying tumor-infiltrating leukocytes in hematoxylin stained NSCLC tissue samples using morphometric features Ergon, Elliott; Harney, Allison S.; Martin, Nathan; Paces, Will; Aeffner, Famke; Wilson, Kristin; Patterson-Kane, Janet; Ryall, Karen; Rudmann, Daniel G.; Hirsch, Brooke; Krueger, Joseph 分享 收藏
The Gold Standard Paradox in Digital Image Analysis Manual Versus Automated Scoring as Ground Truth Aeffner, Famke; Wilson, Kristin; Martin, Nathan T.; Black, Joshua C.; Hendriks, Cris L. Luengo; Bolon, Brad; Rudmann, Daniel G.; Gianani, Roberto; Koegler, Sally R.; Krueger, Joseph; Young, Dave 分享 收藏
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