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K

Kevin M. Tuffy

AstraZeneca
H指数:12
被引数:1,058

个人简介

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教育背景

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工作经历

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荣誉奖项

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High Conservation of the Human Metapneumovirus Fusion Protein in Contemporary Global Sequences Supports Its Continued Relevance for Therapeutic and Prophylactic Consideration

人类副黏病毒融合蛋白在当代全球序列中的高度保守性支持其持续作为治疗和预防考虑的重要性

Microorganisms
IF4.2
2026-10-050
OA
Vancheswaran Gopalakrishnan; Emma Schaefer; John Patterson; Tyler Brady; Joseph R. Francica; Anna S. Kushnir; Ondrej Podlaha; Katie Streicher; Taylor S. Cohen; Anastasia A. Aksyuk; Kevin M. Tuffy
Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape

针对SARS-CoV-2变体广泛中和及抗病毒逃逸的临床抗体前瞻性优化

SCIENCE ADVANCES
IF12.5
2025-03-280
OA
Zhu, Fangqiang; Rajan, Saravanan; Hayes, Conor F.; Kwong, Ka Yin; Goncalves, Andre R.; Zemla, Adam T.; Lau, Edmond Y.; Zhang, Yi; Cai, Yingyun; Goforth, John W.; Landajuela, Mikel; Gilchuk, Pavlo; Kierny, Michael; Dippel, Andrew; Amofah, Bismark; Kaplan, Gilad; Peano, Vanessa Cadevilla; Morehouse, Christopher; Sparklin, Ben; Gopalakrishnan, Vancheswaran; Tuffy, Kevin M.; Nguyen, Amy; Beloor, Jagadish; Kijak, Gustavo; Liu, Chang; Dijokaite-Guraliuc, Aiste; Mongkolsapaya, Juthathip; Screaton, Gavin R.; Petersen, Brenden K.; Desautels, Thomas A.; Bennett, Drew; Segelke, Brent W.; Arrildt, Kathryn T.; Kaul, Samantha; Grzesiak, Emilia A.; da Silva, Felipe Leno; Bates, Thomas W.; Earnhart, Christopher G.; Hopkins, Svetlana; Sundaram, Shivshankar; Esser, Mark T.; Francica, Joseph R.; Faissol, Daniel M.; LLNL Generative Unconstrained Intelligent Drug Engn GUIDE Consortium
Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials (Vol 14, 4347, 2023)
NATURE COMMUNICATIONS
IF15.7
2024-04-080
OAAI
Ahani, Bahar; Tuffy, Kevin M.; Aksyuk, Anastasia A.; Wilkins, Deidre; Abram, Michael E.; Dagan, Ron; Domachowske, Joseph B.; Guest, Johnathan D.; Ji, Hong; Kushnir, Anna; Leach, Amanda; Madhi, Shabir A.; Mankad, Vaishali S.; Simoes, Eric A. F.; Sparklin, Benjamin; Speer, Scott D.; Stanley, Ann Marie; Tabor, David E.; Hamren, Ulrika Wahlby; Kelly, Elizabeth J.; Villafana, Tonya
Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

两项nirsevimab随机临床试验中婴儿RSV感染的分子和表型特征

NATURE COMMUNICATIONS
IF15.7
2023-07-1922
OAAI
Ahani, Bahar; Tuffy, Kevin M.; Aksyuk, Anastasia A.; Wilkins, Deidre; Abram, Michael E.; Dagan, Ron; Domachowske, Joseph B.; Guest, Johnathan D.; Ji, Hong; Kushnir, Anna; Leach, Amanda; Madhi, Shabir A.; Mankad, Vaishali S.; Simoes, Eric A. F.; Sparklin, Benjamin; Speer, Scott D.; Stanley, Ann Marie; Tabor, David E.; Hamren, Ulrika Wahlby; Kelly, Elizabeth J.; Villafana, Tonya
Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data
LANCET INFECTIOUS DISEASES
IF31
2023-07-0135
PRE
Wilkins, Deidre; Langedijk, Annefleur C.; Lebbink, Robert Jan; Morehouse, Christopher; Abram, Michael E.; Ahani, Bahar; Aksyuk, Anastasia A.; Baraldi, Eugenio; Brady, Tyler; Chen, Albert Tian; Chi, Hsin; Choi, Eun Hwa; Cohen, Robert; Danilenko, Daria M.; Gopalakrishnan, Vancheswaran; Greenough, Anne; Heikkinen, Terho; Hosoya, Mitsuaki; Keller, Christian; Kelly, Elizabeth J.; Kragten-Tabatabaie, Leyla; Martinon-Torres, Federico; de los Santos, Abiel Homero Mascarenas; Nunes, Marta C.; Palomino, Maria Angelica; Papenburg, Jesse; Pernica, Jeffrey M.; Richmond, Peter; Stein, Renato; Tuffy, Kevin M.; Verwey, Charl; Esser, Mark T.; Tabor, David E.; Bont, Louis J.
Breakthrough SARS-CoV-2 Infections in the PROVENT Prevention Trial Were Not Associated With AZD7442 (Tixagevimab/Cilgavimab) Resistant Variants

PROVENT预防试验中的突破性SARS-CoV-2感染与AZD7442 (Tixagevimab/Cilgavimab) 耐药变体无关

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2023-06-062
OAAI
Tuffy, Kevin M.; Ahani, Bahar; Aksyuk, Anastasia A.; Avila, Miles; Brady, Tyler; Kijak, Gustavo H.; Koh, Gavin; Levin, Myron J.; Roe, Tiffany L.; Schuko, Nicolette; Thissen, Jesse; Ustianowski, Andrew; Zhang, Tianhui; Kelly, Elizabeth J.; Streicher, Katie
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2022-03-09167
OAAI
Loo, Yueh-Ming; McTamney, Patrick M.; Arends, Rosalinda H.; Abram, Michael E.; Aksyuk, Anastasia A.; Diallo, Seme; Flores, Daniel J.; Kelly, Elizabeth J.; Ren, Kuishu; Roque, Richard; Rosenthal, Kim; Streicher, Katie; Tuffy, Kevin M.; Bond, Nicholas J.; Cornwell, Owen; Bouquet, Jerome; Cheng, Lily, I; Dunyak, James; Huang, Yue; Rosenbaum, Anton, I; Reddy, Venkatesh Pilla; Andersen, Hanne; Carnahan, Robert H.; Crowe, James E., Jr.; Kuehne, Ana, I; Herbert, Andrew S.; Dye, John M.; Bright, Helen; Kallewaard, Nicole L.; Pangalos, Menelas N.; Esser, Mark T.

研究方向

暂未获取到该数据
E
Elizabeth J. Kelly
H 指数:35论文数:91被引数:1.5万
A
Anastasia A. Aksyuk
H 指数:16论文数:47被引数:1,487
T
Tyler Brady
H 指数:12论文数:38被引数:748
M
Michael E. Abram
H 指数:35论文数:85被引数:5,495
K
Katie Streicher
H 指数:32论文数:154被引数:4,475
D
Deidre Wilkins
H 指数:22论文数:49被引数:1,447
R
Roe, Tiffany L.
H 指数:0论文数:4被引数:2
B
Bahar Ahani
H 指数:9论文数:31被引数:304
J
Johnathan D. Guest
H 指数:18论文数:35被引数:1,222
S
Scott D. Speer
H 指数:11论文数:14被引数:1,862