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Guobo Shen

Sichuan University
H指数:36
被引数:6,119

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Modification of a SARS-CoV-2 spike-RBD targeting nanobody for pH-dependent binding and its chromatographic engineering for purification of WT and variant S-RBDs with mild elution conditions

对靶向SARS-CoV-2刺突-RBD的纳米抗体进行pH依赖性结合修饰及其色谱工程，用于在温和洗脱条件下纯化野生型和变异型S-RBDs

International Journal of Biological Macromolecules
IF8.5
2025-12-180
PRE
Xindan Zhang; Zimin Chen; Sheng Lin; Fanli Yang; Liyan Guo; Jing Yang; Lingling Wang; Xin Yuan; Pengli Xu; Bin He; Yu Cao; Jian Li; Qi Zhao; Jiong Li; Li Yang; Wei Wang; Zhenling Wang; Jinliang Yang; Jingyun Yang; Guobo Shen
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant

鼻内疫苗结合腺病毒和三聚体亚单位蛋白为SARS-CoV-2 Omicron变种提供更优免疫力

Nature Biomedical Engineering
IF26.6
2025-09-220
OAAI
Weiqi Hong; Ping Cheng; Jingyun Yang; Huashan Shi; Zhenling Wang; Jiong Li; Hong Lei; Dandan Peng; Cai He; Wenyan Ren; Xiangyu Pan; Yuhe Huang; Aqu Alu; Furong Qin; Binhan Wang; Yanan Zhou; Yun Yang; Wenhai Yu; Cong Tang; Qing Huang; Mengli Yang; Bai Li; Jingmei Li; Junbin Wang; Jiayuan Ai; Li Chen; Haiying Que; Zhen Zeng; Jian Liu; Ying Hao; Danyi Ao; Yu Zhang; Xiya Huang; Chunjun Ye; MinYang Fu; Xuemei He; Zhenfei Bi; Xuejiao Han; Min Luo; Hongbo Hu; Wei Cheng; Haohao Dong; Jian Lei; Lu Chen; Xikun Zhou; Wei Wang; Guobo Shen; Jinliang Yang; Xiangrong Song; Yuquan Wei; Shuaiyao Lu; Qiangming Sun; Guangwen Lu; Youchun Wang; Li Yang; Weimin Li; Xiawei Wei
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants

重组蛋白疫苗可诱导针对SARS-CoV-2 JN.1和XBB谱系亚变体的保护性免疫

SIGNAL TRANSDUCTION AND TARGETED THERAPY
IF52.7
2025-02-260
OA
Yang, Jingyun; Hong, Weiqi; Shi, Huashan; Wang, Zhenling; He, Cai; Lei, Hong; Yan, Hong; Alu, Aqu; Ao, Danyi; Chen, Zimin; Zhou, Yanan; Yang, Hao; Yang, Yun; Yu, Wenhai; Tang, Cong; Wang, Junbin; Li, Bai; Huang, Qing; Hu, Hongbo; Cheng, Wei; Dong, Haohao; Lei, Jian; Chen, Lu; Zhou, Xikun; Yang, Li; Wang, Wei; Shen, Guobo; Yang, Jinliang; Song, Xiangrong; Sun, Qiangming; Wang, Youchun; Li, Jiong; Lu, Guangwen; Wei, Yuquan
Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials

三价重组蛋白疫苗诱导对XBB谱系和JN.1亚变体的交叉中和：非临床研究与1期临床试验

NATURE COMMUNICATIONS
IF15.7
2024-12-304
OA
Yang, Jingyun; Hong, Weiqi; Shi, Huashan; He, Cai; Lei, Hong; Zhou, Yanan; Yang, Hao; Alu, Aqu; Chen, Zimin; Yang, Yun; Yu, Wenhai; Tang, Cong; Wang, Junbin; Li, Bai; Huang, Qing; Li, Jiong; Yang, Li; Wang, Wei; Shen, Guobo; Yang, Jinliang; Song, Xiangrong; Su, Zhaoming; Wei, Yuquan; Sun, Qiangming; Lu, Shuaiyao; Wang, Zhenling; Wang, Youchun; Lu, Guangwen
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

鼻内递送亚单位蛋白疫苗可提供针对JN.1和XBB谱系变体的保护性免疫

Signal Transduction and Targeted Therapy
IF52.7
2024-11-200
OAAI
Hong Lei; Weiqi Hong; Jingyun Yang; Cai He; Yanan Zhou; Yu Zhang; Aqu Alu; Jie Shi; Jian Liu; Furong qin; Danyi Ao; Xiya Huang; Zimin Chen; Hao Yang; Yun Yang; Wenhai Yu; Cong Tang; Junbin Wang; Bai Li; Qing Huang; Hongbo Hu; Wei Cheng; Haohao Dong; Jian Lei; Lu Chen; Xikun Zhou; Jiong Li; Li Yang; Zhenling Wang; Wei Wang; Guobo Shen; Jinliang Yang; Zhiwei Zhao; Xiangrong Song; Guangwen Lu; Qiangming Sun; Youchun Wang; Shuaiyao Lu; Xiawei Wei

研究方向

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Y
Yuquan Wei
H 指数:111论文数:1,207被引数:5.5万
X
Xiawei Wei
H 指数:28论文数:61被引数:4,251
王
王薇
H 指数:56论文数:289被引数:1.8万
杨静 封面图
杨静
H 指数:87论文数:2,905被引数:4.2万
L
Li Yang
H 指数:41论文数:258被引数:6,657
S
Shi H
H 指数:40论文数:325被引数:7,055
W
Weiqi Hong
H 指数:29论文数:74被引数:6,826
M
Min Luo
H 指数:44论文数:333被引数:9,028
S
Shufang Liang
H 指数:34论文数:146被引数:3,454
J
Jiong Li
H 指数:31论文数:149被引数:5,206