Philip L. Lorenzi - Publications, H-index & Citations

Philip L. Lorenzi

The University of Texas MD Anderson Cancer Center

50H指数

449论文数

1.7W被引数

收录论文 127

发表时间

Inflammatory neuropathy in mouse and primate models of colorectal cancer 结直肠癌小鼠和灵长类动物模型中的炎性神经病变

Nature Communications

IF15.7

2026-08-12

OAAI

Caitlyn M. Gaffney; Angela M. Casaril; Iqbal Mahmud; Bo Wei; Yanyan Jiang; Nathan T. Fiore; Jialu Liu; Karen M. Valadez; Elizabeth A. Kolb; Fisher R. Cherry; Lei Shi; Kenneth Dunner; Philip L. Lorenzi; Steven R. Reiken; Peter M. Grace; Rajasekaran Mahalingam; Theresa A. Guise; Carolyn L. Hodo; Andrew J. Shepherd

High-throughput multi-organ proteomics workflow for drug efficacy and toxicity analysis 用于药物功效和毒性分析的高通量多器官蛋白质组学工作流程

Nature Communications

IF15.7

2026-02-09

OAAI

Yun Xiong; Lin Tan; Wai-kin Chan; Dandan Zhu; Huimin Zhang; Eric S. Yin; Sri Ramya Donepudi; Jibin Ding; Bo Wei; Bao Tran; Sara Martinez; Iqbal Mahmud; Faiza Hanif Waghu; Hamish I. Stewart; Daniel J. Hermanson; Rehan Akbani; John N. Weinstein; Junjie Chen; Philip L. Lorenzi

The glutaminase activity of ASNS fuels glutamine metabolism in leukemia 天冬酰胺合酶的谷氨酰胺酶活性为白血病中的谷氨酰胺代谢提供燃料

Haematologica

IF7.9

2026-02-01

OAAI

Chan, Wai-Kin; Tan, Lin; Martinez, Sara A.; Du, Di; Horvath, Thomas D.; Pontikos, Michael; Rusling, Leona A.; Chiu, Yulun; Tran, Bao Q.; Rempe, Susan B.; Sukharev, Sergei; Weinstein, John N.; Lorenzi, Philip L.

Supercharging-enhanced nDIA-MS enables global profiling of drug-induced proteome solubility shifts 增压增强的ndiia-MS可以对药物诱导的蛋白质组溶解度变化进行全局分析

Nature Communications

IF15.7

2026-01-30

OAAI

Yun Xiong; Huimin Zhang; Lin Tan; Bo Wei; John N. Weinstein; Philip L. Lorenzi

Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer KDM6A介导的基因组不稳定性和代谢重编程的丧失调控膀胱癌对治疗干扰的反应

Nature Communications

IF15.7

2026-01-07

OAAI

Pratishtha Singh; Ranit D’Rozario; Bidisha Chakraborty; Swadhin Meher; Deblina Raychaudhuri; Aminah J. Tannir; Yang Li; Anurag Majumdar; Jessalyn Hawkins; Yun Xiong; Philip Lorenzi; Padmanee Sharma; Kadir Akdemir; Patrick Pilie; Abhinav K. Jain; Byron Hing Lung Lee; Sangeeta Goswami

Publisher Correction: Systemic Metabolic Alterations After Aneurysmal Subarachnoid Hemorrhage: A Plasma Metabolomics Approach 出版者更正：动脉瘤性蛛网膜下腔出血后的系统性代谢改变：一种血浆代谢组学方法

Neurocritical Care

IF3.6

2025-12-05

OAAI

Bosco Seong Kyu Yang; Jude P. J. Savarraj; Hua Chen; Sarah N. Hinds; Glenda L. Torres; Alice S. Ryan; Folefac D. Atem; Philip L. Lorenzi; Xuefang S. Ren; Louise D. McCullough; Neeraj Badjatia; Huimahn A. Choi; Aaron M. Gusdon

CARBOPLATIN IMPAIRS OPTIC NERVE MYELINATION IN NEUROFIBROMATOSIS TYPE 1 (NF1) BY REDUCING CHOLESTEROL LEVELS AND INDUCING OLIGODENDROCYTE LOSS 卡铂通过降低胆固醇水平和诱导少突胶质细胞丢失，损害神经纤维瘤病1型（NF1）视神经的髓鞘化。

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Aghoghovwia, Benjamin; El-Toukhy, Hana; Hamblett, Ava; Chandramouli, Varsha; Ban, Kechen; Stavropoulos, Dimitrios; Wei, Bo; Lorenzi, Philip; Chang, Kun-Che; Mahalingam, Rajasekaran; Pan, Yuan

Systemic Metabolic Alterations After Aneurysmal Subarachnoid Hemorrhage: A Plasma Metabolomics Approach 动脉瘤性蛛网膜下腔出血后的系统性代谢改变：一种血浆代谢组学方法

Neurocritical Care

IF3.6

2025-10-23

PREAI

Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD 果糖和葡萄糖来自含糖饮料，通过SORD增强结直肠癌转移。

Nature Metabolism

IF20.8

2025-09-19

OAAI

Tianshi Feng; Qin Luo; Yanlin Liu; Zeyu Jin; David Skwarchuk; Rumi Lee; Miso Nam; John M. Asara; Daya R. Adye; Philip L. Lorenzi; Lin Tan; Guangsheng Pei; Zhongming Zhao; Neda Zarrin-Khameh; Adriana Paulucci-Holthauzen; Brian W. Simons; Ju-Seog Lee; Scott Kopetz; Jihye Yun

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma TCA循环模式切换决定了套细胞淋巴瘤中耐普拉替诺的持续存在细胞的命运

Blood

IF23.1

2025-07-25

OAAI

Wei Wang; Qingsong Cai; Yang Liu; Lei Nie; Heng-Huan Lee; Fangfang Yan; Yue Fei; Yixin Yao; Yijing Li; Lin Tan; Philip L. Lorenzi; Ying-Nai Wang; Jun Yao; Zhihong Chen; Joseph Mitchell McIntosh; Cheng-Tai Yu; Preetesh Jain; Vivian C. Jiang; Jovanny Vargas; Xiaolin Li

N-acetylaspartate from fat cells regulates postprandial body temperature 来自脂肪细胞的N-乙酰天门冬氨酸调节餐后体温

Nature Metabolism

IF20.8

2025-07-23

OAAI

Jessica B. Felix; Pradip K. Saha; Evelyn L. de Groot; Lin Tan; Robert Sharp; Elizabeth S. Anaya; Yafang Li; Holly Quang; Nooshin Saidi; Layla Abushamat; Christie M. Ballantyne; Christopher I. Amos; Philip L. Lorenzi; Samuel Klein; Xia Gao; Sean M. Hartig

CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors CHD1缺失重编程SREBP2驱动的胆固醇合成，以支持雄激素应答性生长和去势抵抗在SPOP突变的前列腺肿瘤中。

NATURE CANCER

IF28.5

2025-05-13

PREAI

Chen, Feiyu; Li, Haoyan; Wang, Yin; Tang, Ximing; Lin, Kevin; Li, Qidong; Meng, Chenling; Shi, Wei; Leo, Javier; Liang, Xin; Zhang, Jie; Van, Vivien; Mahmud, Iqbal; Wei, Bo; Lorenzi, Philip L.; Raso, Maria G.; Aparicio, Ana; Lu, Yue; Frigo, Daniel E.; Gan, Boyi

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer 肿瘤源性花生四烯酸重编程中性粒细胞，以促进三阴性乳腺癌的免疫抑制和疗法抵抗。

IMMUNITY

IF26.3

2025-04-01

PREAI

Yu, Liqun; Liebenberg, Keziah; Shen, Yichao; Liu, Fengshuo; Xu, Zhan; Hao, Xiaoxin; Wu, Ling; Zhang, Weijie; Chan, Hilda L.; Wei, Bo; Lorenzi, Philip L.; Gao, Yang; Bado, Igor; Becerra-Dominguez, Luis; Rivas, Charlotte Helena; Aguirre, Sergio; Pingel, Bradley C.; Wu, Yi-Hsuan; Ding, Yunfeng; Liu, Jun; Edwards, David G.; Eberlin, Livia S.

Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition 鸟嘌呤核苷酸生物合成阻断会损害MLL复合物形成并使白血病对menin抑制敏感化

NATURE COMMUNICATIONS

IF15.7

2025-03-18

OAAI

Shi, Xiangguo; Li, Minhua; Liu, Zian; Tiessen, Jonathan; Li, Yuan; Zhou, Jing; Zhu, Yudan; Mahesula, Swetha; Ding, Qing; Tan, Lin; Feng, Mengdie; Kageyama, Yuki; Hara, Yusuke; Tao, Jacob J.; Luo, Xuan; Patras, Kathryn A.; Lorenzi, Philip L.; Huang, Suming; Stevens, Alexandra M.; Takahashi, Koichi; Issa, Ghayas C.; Samee, Md. Abul Hassan; Agathocleous, Michalis; Nakada, Daisuke

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome- associated MSH2-deficient endometrial cancer 线粒体缺陷和代谢易损性在林奇综合征相关MSH2缺陷型子宫内膜癌中

JCI INSIGHT

IF6.1

2025-02-18

OAAI

Bowen, Mikayla Borthwick; Melendez, Brenda; Zhang, Qian; Moreno, Diana; Peralta, Leah; Chan, Wai Kin; Jeter, Collene; Tan, Lin; Zal, M. Anna; Lorenzi, Philip L.; Dunner Jr, Kenneth; Yang, Richard K.; Broaddus, Russell R.; Celestino, Joseph; Gokul, Nisha; Whitley, Elizabeth; Scoville, Deena M.; Kim, Tae Hoon; Jeong, Jae-Wook; Schmandt, Rosemarie; Lu, Karen; Kim, Hyun-Eui; Yates, Melinda S.

Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins 肿瘤细胞通过脂肪酸结合蛋白避免免疫细胞诱导的铁死亡。

MOLECULAR CANCER

IF33.9

2025-02-03

OAAI

Freitas-Cortez, Maria Angelica; Masrorpour, Fatemeh; Jiang, Hong; Mahmud, Iqbal; Lu, Yue; Huang, Ailing; Duong, Lisa K.; Wang, Qi; Voss, Tiffany A.; Leyton, Claudia S. Kettlun; Wei, Bo; Chan, Wai-Kin; Lin, Kevin; Zhang, Jie; Tsouko, Efrosini; Ganjoo, Shonik; Barsoumian, Hampartsoum B.; Riad, Thomas S.; Hu, Yun; Leuschner, Carola; Puebla-Osorio, Nahum; Wang, Jing; Hu, Jian; Davies, Michael A.; Puduvalli, Vinay K.; Billon, Cyrielle; Burris, Thomas P.; Lorenzi, Philip L.; Gan, Boyi; Welsh, James W.

Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage 动脉瘤性蛛网膜下腔出血中的代谢组学和脂质组学通路

NEUROTHERAPEUTICS

IF6.9

2025-01-01

OAAI

Yang, Bosco Seong Kyu; Blackburn, Spiros L.; Lorenzi, Philip L.; Choi, Huimahn A.; Gusdon, Aaron M.

Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility

NANOMATERIALS

IF4.3

2024-12-15

OAAI

Vo, Anh T. T.; Mouli, Karthik; Liopo, Anton V.; Lorenzi, Philip; Tan, Lin; Wei, Bo; Martinez, Sara A.; Mchugh, Emily A.; Tour, James M.; Khan, Uffaf; Derry, Paul J.; Kent, Thomas A.

CD38 Activation by Disturbed Flow (d-flow) Promotes Endothelial Cell (EC) Senescence-Associated Stemness (SAS) through Glutaminolysis Enhanced by Pyruvate Dehydrogenase (PDH) Inhibition, Leading to Atherothrombosis 由紊乱血流（d-flow）介导的CD38激活通过谷氨酰胺分解代谢（glutaminolysis）促进内皮细胞（EC）衰老相关干细胞特性（SAS），该过程因丙酮酸脱氢酶（PDH）抑制而增强，最终导致动脉粥样血栓形成。

CIRCULATION

IF38.6

2024-11-12

PREAI

Kotla, Sivareddy; Lee, Jonghae; Osborn, Abigail; Pathania, Rajneesh; Chen, Weiqing; Samanthapudi, Venkata Subrahman K.; Mejia, Gilbert; Oanh Hoang; Kyung Ae Ko; Mendoza, Keila Carolina Ostos; Khanh Chau; Nhat Tu Le; Schadler, Keri; Burks, Jared K.; Seeley, Erin; Lorenzi, Philip; Brookes, Paul; Martin, James; Wang, Guangyu; Chini, Eduardo; Abe, Junichi

Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma

BRITISH JOURNAL OF CANCER

IF6.8

2024-10-11

OAAI

Chattopadhyay, Chandrani; Roszik, Janos; Bhattacharya, Rajat; Alauddin, Md; Mahmud, Iqbal; Yadugiri, Sirisha; Ali, Mir Mustafa; Khan, Fatima S.; Prabhu, Varun Vijay; Lorenzi, Philip L.; Wei, Bo; Burton, Elizabeth; Morey, Rohini R.; Lazcano, Rossana; Davies, Michael A.; Patel, Sapna P.; Grimm, Elizabeth A.

研究方向