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G

Gregory R. J. Thatcher

University of Arizona
H指数:44
被引数:6,663

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Mixed Lineage Kinase Suppression in Triple-Negative Breast Cancer: Identification of a Dual Inhibitor Targeting MLK3 and NAMPT

三阴性乳腺癌中混合谱系激酶的抑制：鉴定靶向MLK3和NAMPT的双靶点抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-06-100
PRE
Ganga Reddy Velma; Sandeep Kumar; Piush Srivastava; Sweta Misra; Rakesh Sathish Nair; Soumya Reddy Musku; Martha Ackerman-Berrier; Sunil Kumar Singh; Harsh Vyas; Erick T. M. Alves; Basabi Rana; Rui Xiong; Laura Bloem; Ajay Rana; Gregory R. J. Thatcher
Discovery of the SARS-CoV-2 Papain-Like Protease Inhibitor MR1–114: From Structure-Based Design to In Vivo Antiviral Efficacy

SARS-CoV-2半胱氨酸蛋白酶抑制剂MR1–114的发现：从基于结构的药物设计到体内抗病毒功效

Journal of Medicinal Chemistry
IF6.8
2026-03-260
OA
Malla Reddy Gannarapu; Divakar Indukuri; Cameron Holberg; Kiira Ratia; Omar Lozano Ramos; Savio Cardoza; Ganga Reddy Velma; Soumya Reddy Musku; Zuohuang Qi; Steve Slilaty; Zuomei Li; Lijun Rong; Gregory R J Thatcher; Rui Xiong
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity

SARS-CoV-2木瓜蛋白酶样蛋白酶 (PLpro) 的非共价抑制剂: 体外和体内抗病毒活性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-051
OAAI
Velma, Ganga Reddy; Shen, Zhengnan; Holberg, Cameron; Fu, Jiqiang; Soleymani, Farinaz; Cooper, Laura; Ramos, Omar Lozano; Indukuri, Divakar; Musku, Soumya Reddy; Rychetsky, Pavel; Slilaty, Steve; Li, Zuomei; Ratia, Kiira; Rong, Lijun; Schenten, Dominik; Xiong, Rui; Thatcher, Gregory R.
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo

具有体内杀血吸虫活性的硫氧还蛋白谷胱甘肽还原酶的非共价抑制剂

NATURE COMMUNICATIONS
IF15.7
2023-06-2215
OAAI
Petukhova, Valentina Z.; Aboagye, Sammy Y.; Ardini, Matteo; Lullo, Rachel P.; Fata, Francesca; Byrne, Margaret E.; Gabriele, Federica; Martin, Lucy M.; Harding, Luke N. M.; Gone, Vamshikrishna; Dangi, Bikash; Lantvit, Daniel D.; Nikolic, Dejan; Ippoliti, Rodolfo; Effantin, Gregory; Ling, Wai Li; Johnson, Jeremy J.; Thatcher, Gregory R. J.; Angelucci, Francesco; Williams, David L.; Petukhov, Pavel A.
Structure-Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

低氧诱导因子脯氨酰羟化酶抑制剂的构效关系及转录组学分析

ANTIOXIDANTS
IF6.6
2022-01-244
OAAI
Poloznikov, Andrey A.; Nikulin, Sergey V.; Hushpulian, Dmitry M.; Khristichenko, Anna Yu.; Osipyants, Andrey I.; Asachenko, Andrey F.; Shurupova, Olga V.; Savin, Svyatoslav S.; Lee, Sue H.; Gaisina, Irina N.; Thatcher, Gregory R. J.; Narciso, Anthony; Chang, Eric P.; Kazakov, Sergey V.; Krucher, Nancy; Tishkov, Vladimir I.; Thomas, Bobby; Gazaryan, Irina G.

研究方向

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R
Rui Xiong
H 指数:25论文数:121被引数:1,959
J
Judy L. Bolton
H 指数:55论文数:196被引数:1.0万
D
Debra A. Tonetti
H 指数:30论文数:159被引数:2,564
P
Pavel A. Petukhov
H 指数:31论文数:119被引数:2,784
J
Jiong Zhao
H 指数:16论文数:37被引数:1,181
Z
Zhihui Qin
H 指数:40论文数:114被引数:5,393
I
Irida Kastrati
H 指数:16论文数:85被引数:1,026
K
Kiira Ratia
H 指数:26论文数:77被引数:4,579
L
Lauren M. Gutgesell
H 指数:5论文数:23被引数:271
R
R. Esala P. Chandrasena
H 指数:16论文数:28被引数:976