Luise Linsenmeier

university of hamburg

H指数:10

被引数:488

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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

ACTA NEUROPATHOLOGICA

IF9.3

2024-07-090

OAAI

Song, Feizhi; Kovac, Valerija; Mohammadi, Behnam; Littau, Jessica L.; Scharfenberg, Franka; Matamoros Angles, Andreu; Vanni, Ilaria; Shafiq, Mohsin; Orge, Leonor; Galliciotti, Giovanna; Djakkani, Salma; Linsenmeier, Luise; Cernilec, Maja; Hartman, Katrina; Jung, Sebastian; Tatzelt, Joerg; Neumann, Julia E.; Damme, Markus; Tschirner, Sarah K.; Lichtenthaler, Stefan F.; Ricklefs, Franz L.; Sauvigny, Thomas; Schmitz, Matthias; Zerr, Inga; Puig, Berta; Tolosa, Eva; Ferrer, Isidro; Magnus, Tim; Rupnik, Marjan S.; Sepulveda-Falla, Diego; Matschke, Jakob; Smid, Lojze M.; Bresjanac, Mara; Andreoletti, Olivier; Krasemann, Susanne; Foliaki, Simote T.; Nonno, Romolo; Becker-Pauly, Christoph; Monzo, Cecile; Crozet, Carole; Haigh, Cathryn L.; Glatzel, Markus; Curin Serbec, Vladka; Altmeppen, Hermann C.

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

与病毒蛋白结合的配体诱导其蛋白水解释放，在神经退行性蛋白质病中具有治疗潜力

SCIENCE ADVANCES

IF12.5

2021-11-2618

OAAI

Linsenmeier, Luise; Mohammadi, Behnam; Shafiq, Mohsin; Frontzek, Karl; Bar, Julia; Shrivastava, Amulya N.; Damme, Markus; Song, Feizhi; Schwarz, Alexander; Da Vela, Stefano; Massignan, Tania; Jung, Sebastian; Correia, Angela; Schmitz, Matthias; Puig, Berta; Hornemann, Simone; Zerr, Inga; Tatzelt, Jorg; Biasini, Emiliano; Saftig, Paul; Schweizer, Michaela; Svergun, Dmitri; Amin, Ladan; Mazzola, Federica; Varani, Luca; Thapa, Simrika; Gilch, Sabine; Schatzl, Hermann; Harris, David A.; Triller, Antoine; Mikhaylova, Marina; Aguzzi, Adriano; Altmeppen, Hermann C.; Glatzel, Markus

Pharmacological inactivation of the prion protein by targeting a folding intermediate

通过靶向折叠中间体对朊病毒蛋白进行药理学失活

COMMUNICATIONS BIOLOGY

IF5.1

2021-01-1240

OAAI

Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Rigoli, Marta; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Bonaldo, Valerio; Maietta, Giulia; Lorenzo, Nuria L.; Fernandez, Leticia C.; Codeseira, Yaiza B.; Tosatto, Laura; Linsenmeier, Luise; Vignoli, Beatrice; Petris, Gianluca; Gasparotto, Dino; Pennuto, Maria; Guella, Graziano; Canossa, Marco; Altmeppen, Hermann C.; Lolli, Graziano; Biressi, Stefano; Pastor, Manuel M.; Requena, Jesus R.; Mancini, Ines; Barreca, Maria L.; Faccioli, Pietro; Biasini, Emiliano

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

ACTA NEUROPATHOLOGICA

IF9.3

2019-10-3123

OAAI

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

PLOS PATHOGENS

IF4.9

2019-01-0436

OAAI

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

MOLECULAR NEURODEGENERATION