Stephen J. Perkins - Publications, H-index & Citations

Stephen J. Perkins

university college london

58H指数

306论文数

1.1W被引数

收录论文 107

发表时间

Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy 人类二聚体IgA1溶液结构的原子散射建模揭示了IgA肾病结构和机制的基础

Journal of Biological Chemistry

IF3.9

2026-05-14

OAAI

Jayesh S. Bhatt; See Cheng Yeo; Sam M. Ireland; Aisha Ben-Younis; Jayesh Gor; Karen Molyneux; Jonathan Barratt; Stephen J. Perkins

Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies 纤溶酶对β2-糖蛋白I的裂解改变了其结构和与致病性抗体的结合能力

Journal of Thrombosis and Haemostasis

IF5

2025-02-24

OAAI

Hannah F. Bradford; Christophe J. Lalaurie; Jayesh Gor; Xin Gao; Charis Pericleous; Stephen J. Perkins; Hannah Britt; Konstantinos Thalassinos; Ian Giles; Anisur Rahman; Mihaela Delcea; Paul A. Dalby; Thomas C.R. McDonnell

The SCR-17 and SCR-18 glycans in human complement factor H enhance its regulatory function

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-09-01

OAAI

Gao, Xin; Iqbal, Hina; Yu, Ding-Quan; Gor, Jayesh; Coker, Alun R.; Perkins, Stephen J.

The solution structure of the heavy chain-only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-11-01

OAAI

Gao, Xin; Thrush, Joseph W.; Gor, Jayesh; Naismith, James H.; Owens, Raymond J.; Perkins, Stephen J.

An updated interactive database for 1692 genetic variants in coagulation factor IX provides detailed insights into hemophilia B 更新的1692凝血因子IX基因变异的交互式数据库提供了对血友病B的详细见解

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2023-05-01

OAAI

Xu, Ziqian; Spencer, Holly J.; Harris, Victoria A.; Perkins, Stephen J.

A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-02-01

OAAI

Iqbal, Hina; Fung, Ka Wai; Gor, Jayesh; Bishop, Anthony C.; Makhatadze, George I.; Brodsky, Barbara; Perkins, Stephen J.

Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2022-09-01

OAAI

Lalaurie, Christophe J.; Splevins, Andrew; Barata, Teresa S.; Bunting, Karen A.; Higazi, Daniel R.; Zloh, Mire; Spiteri, Valentina A.; Perkins, Stephen J.; Dalby, Paul A.

Identification of diverse lipid-binding modes in the groove of zinc α2 glycoprotein reveals its functional versatility

FEBS JOURNAL

IF4.2

2021-12-07

OAAI

Zahid, Henna; Lau, Andy M.; Kelly, Sharon M.; Karu, Kersti; Gor, Jayesh; Perkins, Stephen J.; McDermott, Lindsay C.

Clinicopathologic Implications of Complement Genetic Variants in Kidney Transplantation

FRONTIERS IN MEDICINE

IF3

2021-11-29

OAAI

Ren, Zhen; Perkins, Stephen J.; Love-Gregory, Latisha; Atkinson, John P.; Java, Anuja

Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-09-01

OAAI

Spiteri, Valentina A.; Goodall, Margaret; Doutch, James; Rambo, Robert P.; Gor, Jayesh; Perkins, Stephen J.

Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation

BIOPHYSICAL JOURNAL

IF3.1

2021-05-01

OAAI

Spiteri, Valentina A.; Doutch, James; Rambo, Robert P.; Gor, Jayesh; Dalby, Paul A.; Perkins, Stephen J.

A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-01-21

OAAI

Dunne, Orla M.; Gao, Xin; Nan, Ruodan; Gor, Jayesh; Adamson, Penelope J.; Gordon, David L.; Moulin, Martine; Haertlein, Michael; Forsyth, V. Trevor; Perkins, Stephen J.

The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-11-01

OAAI

Kadkhodayi-Kholghi, Nilufar; Bhatt, Jayesh S.; Gor, Jayesh; McDermott, Lindsay C.; Gale, Daniel P.; Perkins, Stephen J.

The EAHAD blood coagulation factor VII variant database

HUMAN MUTATION

IF3.7

2020-04-29

OAAI

Giansily-Blaizot, Muriel; Rallapalli, Pavithra M.; Perkins, Stephen J.; Kemball-Cook, Geoffrey; Hampshire, Daniel J.; Gomez, Keith; Ludlam, Christopher A.; McVey, John H.

The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers 欧洲血友病和相关疾病协会 (eahand) 凝血因子变体数据库: 止血临床医生和研究人员的重要资源

HAEMOPHILIA

IF3

2020-03-13

OAAI

McVey, John H.; Rallapalli, Pavithra M.; Kemball-Cook, Geoffrey; Hampshire, Daniel J.; Giansily-Blaizot, Muriel; Gomez, Keith; Perkins, Stephen J.; Ludlam, Christopher A.

Atomistic Modeling of Scattering Curves for Human IgG1/4 Reveals New Structure-Function Insights

BIOPHYSICAL JOURNAL

IF3.1

2019-12-01

OAAI

Wright, David W.; Elliston, Emma L. K.; Hui, Gar Kay; Perkins, Stephen J.

Crystal structure of zinc-α2-glycoprotein in complex with a fatty acid reveals multiple different modes of protein-lipid binding

BIOCHEMICAL JOURNAL

IF4.3

2019-10-11

OAAI

Lau, Andy M.; Zahid, Henna; Gor, Jayesh; Perkins, Stephen J.; Coker, Alun R.; McDermott, Lindsay C.

The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-07-01

OAAI

Hui, Gar Kay; Gardener, Antoni D.; Begum, Halima; Eldrid, Charles; Thalassinos, Konstantinos; Gor, Jayesh; Perkins, Stephen J.

Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-11-01

OAAI

Osborne, Amy J.; Nan, Ruodan; Miller, Ami; Bhatt, Jayesh S.; Gor, Jayesh; Perkins, Stephen J.

Statistical Validation; Rare Complement Variants Provides Insights into the Molecular Basis; Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

JOURNAL OF IMMUNOLOGY

IF3.4

2018-04-01

128

OAAI

Osborne, Amy J.; Breno, Matteo; Borsa, Nicolo Ghiringhelli; Bu, Fengxiao; Fremeaux-Bacchi, Veronique; Gale, Daniel P.; van den Heuvel, Lambertus P.; Kavanagh, David; Noris, Marina; Pinto, Sheila; Rallapalli, Pavithra M.; Remuzzi, Giuseppe; de Cordoba, Santiago Rodriguez; Ruiz, Angela; Smith, Richard J. H.; Vieira-Martins, Paula; Volokhina, Elena; Wilson, Valerie; Goodship, Timothy H. J.; Perkins, Stephen J.

研究方向