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J

J. Arjuna Ratnayaka

University of Southampton
H指数:20
被引数:3,751

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Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD)

Sigma-2受体调节剂CT1812改变关键通路并挽救与干性年龄相关性黄斑变性 (AMD) 相关的视网膜色素上皮 (RPE) 功能缺陷

SCIENTIFIC REPORTS
IF3.9
2025-02-100
OAAI
Lizama, Britney N.; Keeling, Eloise; Cho, Eunah; Malagise, Evi M.; Knezovich, Nicole; Waybright, Lora; Watto, Emily; Look, Gary; Di Caro, Valentina; Caggiano, Anthony O.; Ratnayaka, J. Arjuna; Hamby, Mary E.
Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

寡聚Aβ1-42诱导AMD样表型并在溶酶体中积累以损害RPE功能

CELLS
IF5.2
2021-02-179
OAAI
Lynn, Savannah A.; Johnston, David A.; Scott, Jenny A.; Munday, Rosie; Desai, Roshni S.; Keeling, Eloise; Weaterton, Ruaridh; Simpson, Alexander; Davis, Dillon; Freeman, Thomas; Chatelet, David S.; Page, Anton; Cree, Angela J.; Lee, Helena; Newman, Tracey A.; Lotery, Andrew J.; Ratnayaka, J. Arjuna
In vitrostem cell modelling demonstrates a proof-of-concept for excess functional mutantTIMP3as the cause ofSorsbyfundusdystrophy

在体外干细胞模型中，证明了过度功能性突变timp3的概念证明是导致肌肉萎缩的原因

JOURNAL OF PATHOLOGY
IF5.2
2020-07-319
OAAI
Hongisto, Heidi; Dewing, Jennifer M.; Christensen, David R. G.; Scott, Jennifer; Cree, Angela J.; Nattinen, Janika; Maatta, Juha; Jylha, Antti; Aapola, Ulla; Uusitalo, Hannu; Kaarniranta, Kai; Ratnayaka, J. Arjuna; Skottman, Heli; Lotery, Andrew J.
A small gene sequencing panel realises a high diagnostic rate in patients with congenital nystagmus following basic phenotyping

一个小的基因测序小组在基本表型后实现了先天性眼球震颤患者的高诊断率

SCIENTIFIC REPORTS
IF3.9
2019-09-135
OAAI
O'Gorman, Luke; Norman, Chelsea S.; Michaels, Luke; Newall, Tutte; Crosby, Andrew H.; Mattocks, Christopher; Cree, Angela J.; Lotery, Andrew J.; Baple, Emma L.; Ratnayaka, J. Arjuna; Baralle, Diana; Lee, Helena; Osborne, Daniel; Shawkat, Fatima; Gibson, Jane; Ennis, Sarah; Self, Jay E.
A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy

视网膜退行性变的激光小鼠模型显示出渐进性的外部视网膜病理，提供了对早期地理萎缩的见解

SCIENTIFIC REPORTS
IF3.9
2019-05-1616
OAAI
Ibbett, Paul; Goverdhan, Srinivas V.; Pipi, Elena; Chouhan, Joe K.; Keeling, Eloise; Angus, Elizabeth M.; Scott, Jenny A.; Gatherer, Maureen; Page, Anton; Teeling, Jessica L.; Lotery, Andrew J.; Ratnayaka, J. Arjuna
Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B)

鉴定导致低形态眼皮肤白化病 (OCA1B) 的酪氨酸酶基因 (TYR) 中具有功能意义的三等位基因基因型

SCIENTIFIC REPORTS
IF3.9
2017-06-3050
OAAI
Norman, Chelsea S.; O'Gorman, Luke; Gibson, Jane; Pengelly, Reuben J.; Baralle, Diana; Ratnayaka, J. Arjuna; Griffiths, Helen; Rose-Zerilli, Matthew; Ranger, Megan; Bunyan, David; Lee, Helena; Page, Rhiannon; Newall, Tutte; Shawkat, Fatima; Mattocks, Christopher; Ward, Daniel; Ennis, Sarah; Self, Jay E.
The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)

阿尔茨海默氏症相关的淀粉样 β 肽被R28神经视网膜细胞内化，并破坏微管相关蛋白2 (MAP-2)

EXPERIMENTAL EYE RESEARCH
IF2.7
2016-12-0118
OAAI
Taylor-Walker, George; Lynn, Savannah A.; Keeling, Eloise; Munday, Rosie; Johnston, David A.; Page, Anton; Scott, Jennifer A.; Goverdhan, Srini; Lotery, Andrew J.; Ratnayaka, J. Arjuna

研究方向

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A
Andrew Lotery
H 指数:81论文数:667被引数:2.8万
E
Eloise Keeling
H 指数:12论文数:27被引数:356
A
Angela J. Cree
H 指数:32论文数:102被引数:5,857
H
Helena Lee
H 指数:26论文数:128被引数:2,635
S
Savannah A. Lynn
H 指数:7论文数:22被引数:154
J
Jessica L. Teeling
H 指数:40论文数:109被引数:7,979
L
Luminita Paraoan
H 指数:28论文数:99被引数:1,751
J
Jay Self
H 指数:31论文数:143被引数:3,711
R
Rosie Munday
H 指数:4论文数:5被引数:94
K
Kevin Staras
H 指数:34论文数:81被引数:3,692