未登录 分享 收藏
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance (vol 15, 275, 2024) Schroeder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R. 分享 收藏
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches Vulpetti, Anna; Rondeau, Jean-Michel; Bellance, Marie-Helene; Blank, Jutta; Boesch, Ralf; Boettcher, Andreas; Bornancin, Frederic; Buhr, Sylvia; Connor, Lauren E.; Dumelin, Christoph E.; Esser, Oliver; Hediger, Michael; Hintermann, Samuel; Hommel, Ulrich; Koch, Elke; Lapointe, Guillaume; Leder, Lukas; Lehmann, Sylvie; Lehr, Philipp; Meier, Peter; Muller, Lionel; Ostermeier, Daniela; Ramage, Paul; Schiebel-Haddad, Sihame; Smith, Alexander Baxter; Stojanovic, Aleksandar; Velcicky, Juraj; Yamamoto, Rina; Hurth, Konstanze 分享 收藏
Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates Zhang, Alan; Seiss, Katherine; Laborde, Laurent; Palacio-Ramirez, Sebastian; Guthy, Daniel; Lanter, Mylene; Lorber, Julien; Vulpetti, Anna; Arista, Luca; Zoller, Thomas; Radimerski, Thomas; Thoma, Claudio; Hebach, Christina; Tschantz, William R.; Karpov, Alexei; Hollingworth, Gregory J.; D'Alessio, Joseph A.; Ferretti, Stephane; Burger, Matthew T. 分享 收藏
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance Schroder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R. 分享 收藏
分享 收藏
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase Hoegenauer, Klemens; An, Shaojian; Axford, Jake; Benander, Christina; Bergsdorf, Christian; Botsch, Josephine; Chau, Suzanne; Fernandez, Cesar; Gleim, Scott; Hassiepen, Ulrich; Hunziker, Jurg; Joly, Emilie; Keller, Aramis; Romero, Sandra Lopez; Maher, Robert; Mangold, Anne-Sophie; Mickanin, Craig; Mihalic, Manuel; Neuner, Philippe; Patterson, Andrew W.; Perruccio, Francesca; Roggo, Silvio; Scesa, Julien; Schroder, Martin; Shkoza, Dojna; Thai, Binh; Vulpetti, Anna; Renatus, Martin; Reece-Hoyes, John S. 分享 收藏
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field 发现DCAF1的新结合物，DCAF1是靶向蛋白质降解领域中的新兴连接酶靶标 Vulpetti, Anna; Holzer, Philipp; Schmiedeberg, Niko; Imbach-Weese, Patricia; Pissot-Soldermann, Carole; Hollingworth, Gregory J.; Radimerski, Thomas; Thoma, Claudio R.; Stachyra, Therese-Marie; Wojtynek, Matthias; Maschlej, Magdalena; Chau, Suzanne; Schuffenhauer, Ansgar; Fernandez, Cesar; Schroder, Martin; Renatus, Martin 分享 收藏
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation Quancard, Jean; Vulpetti, Anna; Bach, Anders; Cox, Brian; Gueret, Stephanie M.; Hartung, Ingo V.; Koolman, Hannes F.; Laufer, Stefan; Messinger, Josef; Sbardella, Gianluca; Craft, Russell 分享 收藏
分享 收藏
分享 收藏
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase Angst, Daniela; Gessier, Francois; Janser, Philipp; Vulpetti, Anna; Walchli, Rudolf; Beerli, Christian; Littlewood-Evans, Amanda; Dawson, Janet; Nuesslein-Hildesheim, Barbara; Wieczorek, Grazyna; Gutmann, Sascha; Scheufler, Clemens; Hinniger, Alexandra; Zimmerlin, Alfred; Funhoff, Enrico G.; Pulz, Robert; Cenni, Bruno 分享 收藏
Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation 靶向无活性构象的布鲁顿酪氨酸激酶的有效和选择性共价抑制剂的设计 Pulz, Robert; Angst, Daniela; Dawson, Janet; Gessier, Francois; Gutmann, Sascha; Hersperger, Rene; Hinniger, Alexandra; Janser, Philipp; Koch, Guido; Revesz, Laszlo; Vulpetti, Anna; Waelchli, Rudolf; Zimmerlin, Alfred; Cenni, Bruno 分享 收藏
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway Karki, Rajeshri G.; Powers, James; Mainolfi, Nello; Anderson, Karen; Belanger, David B.; Liu, Donglei; Ji, Nan; Jendza, Keith; Gelin, Christine F.; Mac Sweeney, Aengus; Solovay, Catherine; Delgado, Omar; Crowley, Maura; Liao, Sha-Mei; Argikar, Upendra A.; Flohr, Stefanie; La Bonte, Laura R.; Lorthiois, Edwige L.; Vulpetti, Anna; Brown, Ann; Long, Debby; Prentiss, Melissa; Gradoux, Nathalie; de Erkenez, Andrea; Cumin, Frederic; Adams, Christopher; Jaffee, Bruce; Mogi, Muneto 分享 收藏
分享 收藏
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model Carcache, David A.; Vulpetti, Anna; Kallen, Joerg; Mattes, Henri; Orain, David; Stringer, Rowan; Vangrevelinghe, Eric; Wolf, Romain M.; Kaupmann, Klemens; Ottl, Johannes; Dawson, Janet; Cooke, Nigel G.; Hoegenauer, Klemens; Billich, Andreas; Wagner, Juergen; Guntermann, Christine; Hintermann, Samuel 分享 收藏
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D Vulpetti, Anna; Ostermann, Nils; Randl, Stefan; Yoon, Taeyoung; Mac Sweeney, Aengus; Cumin, Frederic; Lorthiois, Edwige; Rudisser, Simon; Erbel, Paul; Maibaum, Jurgen 分享 收藏
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo Lorthiois, Edwige; Anderson, Karen; Vulpetti, Anna; Rogel, Olivier; Cumin, Frederic; Ostermann, Nils; Steinbacher, Stefan; Mac Sweeney, Aengus; Delgado, Omar; Liao, Sha-Mei; Randl, Stefan; Rudisser, Simon; Dussauge, Solene; Fettis, Kamal; Kieffer, Laurence; de Erkenez, Andrea; Yang, Louis; Hartwieg, Constanze; Argikar, Upendra A.; La Bonte, Laura R.; Newton, Ronald; Kansara, Viral; Flohr, Stefanie; Hommel, Ulrich; Jaffee, Bruce; Maibaum, Jurgen 分享 收藏
Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors Vulpetti, Anna; Randl, Stefan; Ruedisser, Simon; Ostermann, Nils; Erbel, Paul; Mac Sweeney, Aengus; Zoller, Thomas; Salem, Bahaa; Gerhartz, Bernd; Cumin, Frederic; Hommel, Ulrich; Dalvit, Claudio; Lorthiois, Edwige; Maibaum, Juergen 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
