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Anna Vulpetti

novartis institutes for biomedical research
H指数:36
被引数:5,089

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Fragment-based discovery enables direct targeting of the melanoma oncogene MITF

片段筛选方法能够直接靶向黑色素瘤癌基因MITF

Nature Communications
IF15.7
2025-12-090
OAAI
Deborah Castelletti; Jürgen Hinrichs; Goran Malojčić; Fei Ji; Aurore Desplat; Bryn Reimer; Christelle Henry; Kathryn A. Porter; Fanny Mermet-Meillon; Markus Wartmann; Emmanuelle Wirth; Cécile Delmas; César Fernández; Philipp H. O. Mayer; Niko Schmiedeberg; Simone Plattner; Jvan Brun; Stephan Kläusler; Jessica Kurmann; Kelly Yan; John Fuller; Fanny Schaeffer; Danilo Maddalo; Marc Altorfer; Nikoletta Piperidou; Nicolas Pautrieux; Frederic Baysang; Markus Kaufmann; Amanda Cobos-Correa; Rainer Wilcken; Martin Renatus; Anna Vulpetti; Wolfgang Jahnke
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance (vol 15, 275, 2024)
NATURE COMMUNICATIONS
IF15.7
2024-08-190
OAAI
Schroeder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-05-100
PRE
Vulpetti, Anna; Rondeau, Jean-Michel; Bellance, Marie-Helene; Blank, Jutta; Boesch, Ralf; Boettcher, Andreas; Bornancin, Frederic; Buhr, Sylvia; Connor, Lauren E.; Dumelin, Christoph E.; Esser, Oliver; Hediger, Michael; Hintermann, Samuel; Hommel, Ulrich; Koch, Elke; Lapointe, Guillaume; Leder, Lukas; Lehmann, Sylvie; Lehr, Philipp; Meier, Peter; Muller, Lionel; Ostermeier, Daniela; Ramage, Paul; Schiebel-Haddad, Sihame; Smith, Alexander Baxter; Stojanovic, Aleksandar; Velcicky, Juraj; Yamamoto, Rina; Hurth, Konstanze
Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates
BIOCONJUGATE CHEMISTRY
IF3.9
2024-01-243
PRE
Zhang, Alan; Seiss, Katherine; Laborde, Laurent; Palacio-Ramirez, Sebastian; Guthy, Daniel; Lanter, Mylene; Lorber, Julien; Vulpetti, Anna; Arista, Luca; Zoller, Thomas; Radimerski, Thomas; Thoma, Claudio; Hebach, Christina; Tschantz, William R.; Karpov, Alexei; Hollingworth, Gregory J.; D'Alessio, Joseph A.; Ferretti, Stephane; Burger, Matthew T.
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
NATURE COMMUNICATIONS
IF15.7
2024-01-0421
OA
Schroder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R.; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, Boyee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomae, Nicolas H.; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R.
Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-11-1315
PRE
Hoegenauer, Klemens; An, Shaojian; Axford, Jake; Benander, Christina; Bergsdorf, Christian; Botsch, Josephine; Chau, Suzanne; Fernandez, Cesar; Gleim, Scott; Hassiepen, Ulrich; Hunziker, Jurg; Joly, Emilie; Keller, Aramis; Romero, Sandra Lopez; Maher, Robert; Mangold, Anne-Sophie; Mickanin, Craig; Mihalic, Manuel; Neuner, Philippe; Patterson, Andrew W.; Perruccio, Francesca; Roggo, Silvio; Scesa, Julien; Schroder, Martin; Shkoza, Dojna; Thai, Binh; Vulpetti, Anna; Renatus, Martin; Reece-Hoyes, John S.
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field

发现DCAF1的新结合物，DCAF1是靶向蛋白质降解领域中的新兴连接酶靶标

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-06-0218
PRE
Vulpetti, Anna; Holzer, Philipp; Schmiedeberg, Niko; Imbach-Weese, Patricia; Pissot-Soldermann, Carole; Hollingworth, Gregory J.; Radimerski, Thomas; Thoma, Claudio R.; Stachyra, Therese-Marie; Wojtynek, Matthias; Maschlej, Magdalena; Chau, Suzanne; Schuffenhauer, Ansgar; Fernandez, Cesar; Schroder, Martin; Renatus, Martin
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-04-1715
PREAI
Karki, Rajeshri G.; Powers, James; Mainolfi, Nello; Anderson, Karen; Belanger, David B.; Liu, Donglei; Ji, Nan; Jendza, Keith; Gelin, Christine F.; Mac Sweeney, Aengus; Solovay, Catherine; Delgado, Omar; Crowley, Maura; Liao, Sha-Mei; Argikar, Upendra A.; Flohr, Stefanie; La Bonte, Laura R.; Lorthiois, Edwige L.; Vulpetti, Anna; Brown, Ann; Long, Debby; Prentiss, Melissa; Gradoux, Nathalie; de Erkenez, Andrea; Cumin, Frederic; Adams, Christopher; Jaffee, Bruce; Mogi, Muneto
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-06-3028
PREAI
Lorthiois, Edwige; Anderson, Karen; Vulpetti, Anna; Rogel, Olivier; Cumin, Frederic; Ostermann, Nils; Steinbacher, Stefan; Mac Sweeney, Aengus; Delgado, Omar; Liao, Sha-Mei; Randl, Stefan; Rudisser, Simon; Dussauge, Solene; Fettis, Kamal; Kieffer, Laurence; de Erkenez, Andrea; Yang, Louis; Hartwieg, Constanze; Argikar, Upendra A.; La Bonte, Laura R.; Newton, Ronald; Kansara, Viral; Flohr, Stefanie; Hommel, Ulrich; Jaffee, Bruce; Maibaum, Jurgen

研究方向

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C
Claudio Dalvit
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M
Maria Gabriella Brasca
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P
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H 指数:26论文数:108被引数:2,594
F
Francesco Fiorentini
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W
Wilma Pastori
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C
Ciro Mercurio
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A
Alexander D. Cameron
H 指数:47论文数:249被引数:8,828
M
Mario Varasi
H 指数:37论文数:194被引数:4,360
M
Marina Ciomei
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F
Fulvia Roletto
H 指数:19论文数:50被引数:1,380