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O

Olaf Tyc

goethe university frankfurt
H指数:19
被引数:1,546

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荣誉奖项

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Safety, pharmacokinetics, and preliminary efficacy of VS-01, an intraperitoneal liposomal infusion, in patients with decompensated liver cirrhosis, ascites, and covert hepatic encephalopathy: a phase 1b, first-in-human, open-label, non-randomised, single ascending and multiple dose study

安全性、药代动力学及VS-01（一种腹腔内脂质体输注）在失代偿期肝硬化、腹水及隐匿性肝性脑病患者的初步疗效：一项1b期、首次人体、开放标签、非随机化、单次及多次递增剂量研究

The Lancet Gastroenterology & Hepatology
IF38.6
2026-02-170
OAAI
Frank Erhard Uschner; Martin McCoy; Olaf Tyc; Wenyi Gu; Philip Ferstl; Maximilian Joseph Brol; Johannes Masseli; Kai-Henrik Peiffer; Fabian Finkelmeier; Stefan Zeuzem; Sophie Biguenet; Katharina Staufer; Meriam Kabbaj; Jonel Trebicka
Enterococcus faecium DNA in acute decompensated cirrhosis: a key player in inflammation and kidney dysfunction

屎肠球菌DNA在急性失代偿性肝硬化中的作用：炎症和肾功能不全的关键因素

Frontiers in Medicine
IF3
2025-10-200
OAAI
Olaf Tyc; Nico Kraus; Toska Wiedemann; Hans-Peter Erasmus; Cristina Ortiz; Jessica Vasseur; Kai Hourfar; Christian Seidl; Marcus Maximilian Mücke; Holger Storf; Iulia Dahmer; Eva Herrmann; Stefan Zeuzem; Volkhard A. J. Kempf; Jonel Trebicka; Christoph Welsch; Angela Brieger
Enhanced surface colonisation and competition during bacterial adaptation to a fungus

细菌适应真菌过程中增强的表面定植和竞争

NATURE COMMUNICATIONS
IF15.7
2024-05-273
OAAI
Richter, Anne; Blei, Felix; Hu, Guohai; Schwitalla, Jan W.; Lozano-Andrade, Carlos N.; Xie, Jiyu; Jarmusch, Scott A.; Wibowo, Mario; Kjeldgaard, Bodil; Surabhi, Surabhi; Xu, Xinming; Jautzus, Theresa; Phippen, Christopher B. W.; Tyc, Olaf; Arentshorst, Mark; Wang, Yue; Garbeva, Paolina; Larsen, Thomas Ostenfeld; Ram, Arthur F. J.; van den Hondel, Cees A. M.; Maroti, Gergely; Kovacs, Akos T.
Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1
CELL REPORTS
IF6.9
2023-02-017
OAAI
Ortiz, Cristina; Klein, Sabine; Reul, Winfried H.; Magdaleno, Fernando; Groeschl, Stefanie; Dietrich, Peter; Schierwagen, Robert; Uschner, Frank E.; Torres, Sandra; Hieber, Christoph; Meier, Caroline; Kraus, Nico; Tyc, Olaf; Brol, Maximilian; Zeuzem, Stefan; Welsch, Christoph; Poglitsch, Marco; Hellerbrand, Claus; Alfonso-Prieto, Mercedes; Mira, Fabio; Keller, Ulrich auf dem; Tetzner, Anja; Moore, Andrew; Walther, Thomas; Trebicka, Jonel
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
HEPATOLOGY
IF15.8
2022-10-1310
OAAI
Torres, Sandra; Ortiz, Cristina; Bachtler, Nadine; Gu, Wenyi; Gruenewald, Leon D.; Kraus, Nico; Schierwagen, Robert; Hieber, Christoph; Meier, Caroline; Tyc, Olaf; Brol, Maximilian Joseph; Uschner, Frank Erhard; Nijmeijer, Bart; Welsch, Christoph; Berres, Marie-Luise; Garcia-Ruiz, Carmen; Fernandez-Checa, Jose Carlos; Trautwein, Christian; Vogl, Thomas J.; Zeuzem, Stefan; Trebicka, Jonel; Klein, Sabine
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
FRONTIERS IN MOLECULAR BIOSCIENCES
IF4
2021-08-1319
OAAI
Torres, Sandra; Brol, Maximilian J.; Magdaleno, Fernando; Schierwagen, Robert; Uschner, Frank E.; Klein, Sabine; Ortiz, Cristina; Tyc, Olaf; Bachtler, Nadine; Stunden, James; Bertheloot, Damien; Kitanovic, Ana; Sanchez, Brian; Schrum, Jacob; Roush, William R.; Franchi, Luigi; Byth, Kate; Latz, Eicke; Trebicka, Jonel
Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease
LIVER TRANSPLANTATION
IF3.9
2020-10-0713
OAAI
Tyc, Olaf; Jansen, Christian; Schierwagen, Robert; Uschner, Frank Erhard; Israelsen, Mads; Klein, Sabine; Ortiz, Cristina; Strassburg, Christian P.; Zeuzem, Stefan; Gu, Wenyi; Torres, Sandra; Praktiknjo, Michael; Kersting, Stephan; Langheinrich, Melanie; Nattermann, Jacob; Servant, Florence; Arumugam, Manimozhiyan; Krag, Aleksander; Lelouvier, Benjamin; Weismueller, Tobias J.; Trebicka, Jonel
Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development
JOURNAL OF CLINICAL MEDICINE
IF2.9
2020-08-2818
OAAI
Langheinrich, Melanie; Wirtz, Stefan; Kneis, Barbara; Gittler, Matthias M.; Tyc, Olaf; Schierwagen, Robert; Brunner, Maximilian; Krautz, Christian; Weber, Georg F.; Pilarsky, Christian; Trebicka, Jonel; Agaimy, Abbas; Grutzmann, Robert; Kersting, Stephan

研究方向

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J
Jonel Trebicka
H 指数:92论文数:1,081被引数:4.0万
P
Paolina Garbeva
H 指数:50论文数:135被引数:1.4万
R
Robert Schierwagen
H 指数:39论文数:261被引数:5,444
C
Cristina Ortiz
H 指数:14论文数:50被引数:731
F
Frank Erhard Uschner
H 指数:34论文数:185被引数:4,404
S
Sabine Klein
H 指数:33论文数:145被引数:3,684
S
Sandra Torres
H 指数:22论文数:80被引数:1,900
C
Christoph Welsch
H 指数:28论文数:200被引数:3,976
M
Maximilian Joseph Brol
H 指数:19论文数:92被引数:1,432
W
Wietse de Boer
H 指数:76论文数:429被引数:2.0万