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T

Thomas Kurz

heinrich-heine universität

33H指数
291论文数
3.5K被引数
收录论文 84
发表时间
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Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria羟肟酸作为抗疟疾HDAC抑制剂先导药物
errMedicinal Research Reviews
IF11.6
err2026-05-26
err0
errOAAI
errWisam A. Dawood; Jacinta R. Macdonald; Christian Anzenhofer; Tina S. Skinner-Adams; Robert C. Reid; Thomas Kurz; David P. Fairlie; Katherine T. Andrews
err分享
err收藏
YAK577 Attenuates Vascular Calcification by Targeting an MMP14–NOX2/ROS Axis in VSMCs and a Vitamin D3-Induced Mouse ModelYAK577通过靶向MMP14–NOX2/ROS轴在VSMCs和维生素D3诱导的小鼠模型中减轻血管钙化
errAntioxidants
IF6.6
err2026-05-10
err0
errOAAI
errHongyan Zhou; Hae Jin Kee; Seong Min Jeong; Liyan Bai; Le Wan; Seong Hoon Kim; Seung Hun Lee; Thomas Kurz; Doo Sun Sim; Myung Ho Jeong; Young Joon Hong
err分享
err收藏
Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights反义 fosmidomycin 类似物作为双底物抑制剂：结合模式阐明和机制见解
errJournal of Medicinal Chemistry
IF6.8
err2026-05-06
err0
PREAI
errStefan Höfmann; Sana Takada; Boris Illarionov; Lais Pessanha de Carvalho; Shin-ichiro Ozawa; Tanja Gangnus; Talea Knak; Mona A. Abdullaziz; Noemi Wladarz; Adelbert Bacher; Yasumitsu Sakamoto; Bjoern B. Burckhardt; Jana Held; Markus Fischer; Nobutada Tanaka; Thomas Kurz
err分享
err收藏
VUScope: a mathematical model for evaluating image-based drug response measurements and predicting long-term incubation outcomesVUScope：一种用于评估基于图像的药物反应测量并预测长期孵育结果数学模型
errBioinformatics
IF5.4
err2026-02-01
err0
PREAI
errTran, Nguyen Khoa; Huynh, My Ky; Kotman, Alexander D.; Jurgens, Martin; Kurz, Thomas; Dietrich, Sascha; Klau, Gunnar W.; Qin, Nan
err分享
err收藏
Neutrophil-driven inflammation in takotsubo syndrome: insights from patient data and a translational murine model
errEuropean Heart Journal
IF35.6
err2025-11-05
err0
PREAI
errK Kurz; E Rawish; U Floegel; C Gragoll; T Rusack; M Schneider; W Raasch; T Puehler; T Kurz; I Eitel; T Stiermaier
err分享
err收藏
Mechanochemical synthesis of α,β-dibromoketones using pyridinium tribromide
errPURE AND APPLIED CHEMISTRY
IF2
err2025-10-01
err0
PREAI
errChang, Wei-Jin; Liew, Sook Yee; Kurz, Thomas; Tan, Siow-Ping
err分享
err收藏
Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites基于戊氧酰胺的组蛋白去乙酰化酶抑制剂对 *Plasmodium falciparum* 寄生虫的抗疟原虫活性
errinternational journal for parasitology drugs and drug resistance
IF0
err2025-08-16
err0
errOAAI
errWisam A. Dawood; Gillian M. Fisher; Josefa Kremeyer; Fabian Fischer; Jessica L. Home; Christopher D. Goodman; Kwong Sum Lam; Alexander G. Maier; Thomas Kurz; Katherine T. Andrews
err分享
err收藏
Epigenetic targeting of DNA damage response (DDR)-related mechanisms to overcome acquired cisplatin resistance of tumor cells表观遗传靶向DNA损伤反应（DDR）相关机制以克服肿瘤细胞获得性顺铂耐药性
errbiochimica et biophysica acta molecular cell research
IF0
err2025-07-02
err0
errOAAI
errMarlena Sekeres; Daniel Lengle; Lena Abbey; Matthias Ulrich Kassack; Fabian Fischer; Thomas Kurz; Gerhard Fritz
err分享
err收藏
New derivatives of benzhydroxamic acid with nematocidal activity against Haemonchus contortus and Caenorhabditis elegans新型苯羟胺酸衍生物对Haemonchus contortus和Caenorhabditis elegans具有杀线虫活性
errinternational journal for parasitology drugs and drug resistance
IF0
err2025-05-20
err0
errOAAI
errJosef Krátký; Markéta Zajíčková; Aya C. Taki; Oliver Michel; Petra Matoušková; Ivan Vokřál; Karolína Štěrbová; Ondřej Vosála; Beate Lungerich; Thomas Kurz; Robin B. Gasser; Karel Harant; Lenka Skálová
err分享
err收藏
Positive allosteric modulation of AMPA receptors via PF4778574 leads to reduced demyelination and clinical disability in experimental models of multiple sclerosisPF4778574对AMPA受体的正向变构调节可减轻实验性多发性硬化模型中的脱髓鞘和临床残疾。
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2025-03-05
err0
errOAAI
errSindi, Mustafa; Dietrich, Michael; Klees, Diana; Gruchot, Joel; Hecker, Christina; Silbereis, John; Issberner, Andrea; Hartung, Hans-Peter; Ruck, Tobias; Stark, Holger; Kurz, Thomas; Kuery, Patrick; Meuth, Sven G.; Albrecht, Philipp
err分享
err收藏
YAK577 Attenuates Cardiac Remodeling and Fibrosis in Isoproterenol-Infused Heart Failure Mice by Downregulating MMP12
errKOREAN CIRCULATION JOURNAL
IF3.1
err2025-01-01
err0
PREAI
errZhou, Hongyan; Kee, Hae Jin; Wan, Le; Asfaha, Yodita; Fischer, Fabian; Kassack, Matthias U.; Kurz, Thomas; Kim, Seong Hoon; Kee, Seung-Jung; Hong, Young Joon; Jeong, Myung Ho
err分享
err收藏
The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents
errMOLECULES
IF4.6
err2024-12-28
err0
errOAAI
errTakada, Sana; Abdullaziz, Mona A.; Hoefmann, Stefan; Knak, Talea; Ozawa, Shin-ichiro; Sakamoto, Yasumitsu; Kurz, Thomas; Tanaka, Nobutada
err分享
err收藏
TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-12-26
err0
PREAI
errKnaab, Tanja C.; Moritz, Alena; de Carvalho, Lais Pessanha; Klein, Saskia; Lungerich, Beate; Lohse, Katharina; Kruse, Linn; Mombo-Ngoma, Ghyslain; Orta, Lily; Thibaud, Jessica L.; de Villiers, Katherine A.; Fidock, David A.; Burckhardt, Bjoern B.; Held, Jana; Wittlin, Sergio; Kurz, Thomas
err分享
err收藏
Expanding the Chemical Space of Reverse Fosmidomycin Analogs
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2024-12-23
err0
PREAI
errKnak, Talea; Takada, Sana; Illarionov, Boris; Krisilia, Violetta; de Carvalho, Lais Pessanha; Lungerich, Beate; Sakamoto, Yasumitsu; Hoefmann, Stefan; Bacher, Adelbert; Kalscheuer, Rainer; Held, Jana; Fischer, Markus; Tanaka, Nobutada; Kurz, Thomas
err分享
err收藏
Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-27
err0
PREAI
errFischer, Fabian; Schliehe-Diecks, Julian; Tu, Jia-Wey; Gangnus, Tanja; Ho, Yu Lin; Hebeis, Mara; Avelar, Leandro A. Alves; Scharov, Katerina; Watrin, Titus; Kemkes, Marie; Stachura, Pawel; Daugs, Katharina; Biermann, Lukas; Kremeyer, Josefa; Horstick, Nadine; Span, Ingrid; Pandyra, Aleksandra A.; Borkhardt, Arndt; Gohlke, Holger; Kassack, Matthias U.; Burckhardt, Bjoern B.; Bhatia, Sanil; Kurz, Thomas
err分享
err收藏
Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia-Reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain
errTRANSPLANTATION
IF5
err2024-09-24
err1
PREAI
errConcors, Seth J.; Hernandez, Paul T.; OBrien, Ciaran; DePaolo, John; Murken, Douglas R.; Aufhauser, David D.; Wang, Zhonglin; Xiong, Yan; Krumeich, Lauren; Ge, Guanghui; Beier, Ulf H.; Bhatti, Tricia R.; Kozikowski, Alan P.; Avelar, Leandro A. Alves; Kurz, Thomas; Hancock, Wayne W.; Levine, Matthew H.
err分享
err收藏
1-Deoxy-D-xylulose D-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors
errBIOCHEMICAL JOURNAL
IF4.3
err2024-08-21
err0
errOAAI
errMazzone, Flaminia; Hoeppner, Astrid; Reiners, Jens; Gertzen, Christoph G. W.; Applegate, Violetta; Abdullaziz, Mona A.; Gottstein, Julia; Degrandi, Daniel; Wesemann, Martina; Kurz, Thomas; Smits, Sander H. J.; Pfeffer, Klaus
err分享
err收藏
Novel Histone Deacetylase (HDAC) Inhibitor Induces Apoptosis and Suppresses Invasion via E-Cadherin Upregulation in Pancreatic Ductal Adenocarcinoma (PDAC)
errPHARMACEUTICALS
IF4.8
err2024-06-07
err2
errOAAI
errSchiedlauske, Katja; Deipenbrock, Alina; Pflieger, Marc; Hamacher, Alexandra; Haensel, Jan; Kassack, Matthias U.; Kurz, Thomas; Teusch, Nicole E.
err分享
err收藏
Characterization of the dehydrogenase-reductase DHRS2 and its involvement in histone deacetylase inhibition in urological malignancies
errEXPERIMENTAL CELL RESEARCH
IF3.5
err2024-06-01
err0
errOAAI
errMueller, Melanie R.; Burmeister, Aaron; Skowron, Margaretha A.; Stephan, Alexa; Soehngen, Christian; Wollnitzke, Philipp; Petzsch, Patrick; Avelar, Leandro A. Alves; Kurz, Thomas; Koehrer, Karl; Levkau, Bodo; Nettersheim, Daniel
err分享
err收藏
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase (DXR)
errACS INFECTIOUS DISEASES
IF3.8
err2024-04-22
err2
PREAI
errAbdullaziz, Mona A.; Takada, Sana; Illarionov, Boris; Pessanha de Carvalho, Lais; Sakamoto, Yasumitsu; Ho''fmann, Stefan; Knak, Talea; Kiffe-Delf, Anna-Lene; Mazzone, Flaminia; Pfeffer, Klaus; Kalscheuer, Rainer; Bacher, Adelbert; Held, Jana; Fischer, Markus; Tanaka, Nobutada; Kurz, Thomas
err分享
err收藏

研究方向

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合作学者
合作期刊
王
王振林 (Zhong Lin Wang)
H 指数: 320 · 论文数: 4.0K
N
Nico van Rooijen
H 指数: 165 · 论文数: 1.0K
L
Lutz Ackermann
H 指数: 140 · 论文数: 1.1K
G
Guido Reifenberger
H 指数: 136 · 论文数: 1.2K
D
Dieter Häussinger
H 指数: 107 · 论文数: 4.7K
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