林玮 (Wei Lin)

University of California San Diego校聘教授

H指数:25

被引数:1,907

个人简介

"江南大学生物工程学院/糖化学与生物技术教育部重点实验室校聘教授，江苏省特聘教授，硕士/博士生导师。博士毕业于北京大学前沿交叉学科研究院-生命科学联合中心（CLS），随后赴美国加州大学圣地亚哥分校从事博士后研究工作，并聘为助理项目科学家。主要研究方向包括化学糖生物学、生物传感器和生物成像技术等方法学开发与应用。在JACS、Nature Communications、Nature Chemical Biology、Current Opinion in Chemical Biology、JBC、ChemBioChem等期刊发表SCI论文近20篇。\n学习工作经历点击展开\n2003.09-2007.07 天津大学药学学士 2007.09-2010.06 天津大学微生物与生化药学硕士 2010.07-2012.08 清华大学/北京大学研究助理 2012.09-2017.06 北京大学整合生命科学（化学）博士 2017.09-2022.08 加州大学圣地亚哥分校博士后 2022.09-2025.08 加州大学圣地亚哥分校助理项目科学家 2025.09-至今江南大学生物工程学院校聘教授\n主要成果点击展开\n主要代表性成果 @ University of California San Diego 1. Lin, W., Chen, Y. and Zhang, J. Versatile Red-shifted Biosensors for in vivo Activity Imaging. (Manuscript in preparation) 2. Zhang, JF. #, Lin, W. #, Huang, L. Y., Kim, S. H., He, X. C., Frei, M. S., Zhong, H., Mehta, S. and Zhang, J. New Generation of FRET-based PKA biosensors with High Sensitivity and Selectivity. (Manuscript in preparation) (#Co-first authors) 3. Ni, G. S., Su, H., Zhu, Y., Dhiman, A., Zhou, H-X.*, Lin, W.*, and Hao, N.* Biophys. J. (Under revision) (*Co-corresponding authors) [bioRxiv (2024) doi: 10.1101/2024.11.06.622393] 4. Lin, W.*, Phatarphekar, A., Zhong, Y., Liu, L., Kwon, H-B., Gerwick, W. H., Wang, Y., Mehta S. and Zhang, J.* Light-gated Integrator for Highlighting Kinase Activity in Living Cells. Nat. Commun. 15, 7804 (2024). (*Co-corresponding authors) 5. Su, Q., Zhang, J. #, Lin, W. #, Zhang, JF., Newton, A. C., Mehta, S., Yang, J. and Zhang, J. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. Nat. Chem. Biol. 21, 501-511 (2025) (#Co-second authors) 6. Gest, A., Sahan, A. Z., Zhong, Y., Lin, W., Mehta, S. and Zhang, J. Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals. Chem. Rev. 124(22):12573-12660 (2024). 7. Lin, W.#, Mo, G.C.H.#, Mehta, S. and Zhang, J. DrFLINC Contextualizes Super-resolution Activity Imaging. J. Am. Chem. Soc. 143, 37, 14951-14955 (2021). (#Co-first authors) 8. Zhang, JF., Liu, B., Hong, I., Mo, A., Roth, R.H., Tenner, B., Lin, W., Zhang, J.Z., Molina, R.S., Drobizhev, M., Hughes, T.E., Tian, L., Huganir, R.L., Mehta, S. and Zhang, J. An Ultrasensitive Biosensor for High-resolution Kinase Activity Imaging in Awake Mice. Nat. Chem. Biol. 17, 39–46 (2021). 9. Lin, W., Mehta, S. and Zhang, J. Genetically Encoded Fluorescent Biosensors Illuminate Kinase Signaling in Cancer. J. Biol. Chem. 294(40): 14814-14822 (2019). @ Peking University 10. Sun, X., Chen, Y., Yang, C., Yang, S., Lin, W., Quan, B., Ding, Q., Chen, X., Wang, C., and Qin, W. Chemical Recording of Pump-Specific Drug Efflux in Living Cells. Angew. Chem. Int. Ed. 63: e202409282 (2024). 11. Xu, Y., Peng, L., Wang, S., Wang, A., Ma, R., Zhou, Y., Yang, J., Sun, D., Lin, W., Chen, X. and Zou, P. Hybrid Indicators for Fast and Sensitive Voltage Imaging. Angew. Chem. Int. Ed. 57(15): 3949-3953 (2018) 12. Lin, W., Gao, L., Qin, K. and Chen, X. in Chemical Biology of Glycoproteins, ed. Tan, Z. and Wang, L., The Royal Society of Chemistry, Cambridge, 2017, p. 280-297. [Book chapter] 13. Lin, W., Gao, L. and Chen, X. Protein-Specific Imaging of O-GlcNAcylation in Single Cells. ChemBioChem. 16, 2571-2575 (2015). [Cover paper] 14. Lin, W., Gao, L. and Chen, X. Protein-Specific Imaging of Posttranslational Modifications. Curr. Opin. Chem. Biol. 28, 156-163 (2015). 15. Lin, L., Liu, L., Zhao, B., Xie, R., Lin, W., Li, H., Shi, M., Chen, Y., Springer, T. A. and Chen, X. Carbon Nanotube-Assisted Optical Activation of TGF-β Signaling by Near-Infrared Light. Nature Nanotech. 10, 465-471 (2015). 16. Yang, Y., Lin, S., Lin, W. and Chen, R. P. Ligand-Assisted Dual-Site Click Labeling of EGFR on Living Cells. ChemBioChem. 15(12): 1738-43 (2014). 17. Lin, W., Du, Y., Zhu, Y. and Chen, X. A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans. J. Am. Chem. Soc. 136, 679-687 (2014). [The first article in Editors’ Choice program; Featured in Chemical & Engineering News 2014, 92(1), 10] @ Tianjin University 18. Jiang, L., Cao, C., Zhang, L., Lin, W., Xia, J., Xu, H. and Zhang, Y. Cadmium-induced activation of high osmolarity glycerol pathway through its Sln1 branch is dependent on the MAP kinase kinase kinase Ssk2, but not its paralog Ssk22, in budding yeast. FEMS Yeast Res. 14(8): 1263-1272 (2014). 19. Zhao, J., Lin, W., Ma, X., Lu, Q., Ma, X., Bian, G. and Jiang, L. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics. 95(5): 290-298 (2010). 获奖情况 2021 高等学校科学研究优秀成果奖-自然科学一等奖 2017 北京大学优秀毕业生 2016 北京大学“三好学生” 2016 博士研究生学业奖学金 2015 北京大学“优秀科研奖” 2015 博士研究生学业奖学金 2014 北京大学“创新奖” 2014 国家奖学金（博士研究生） 2013 北大-清华生命科学联合中心奖学金以上资料更新时间截止：2025年9月"