Jian-Ke Tie

University of North Carolina at Chapel Hill

H指数:21

被引数:1,386

个人简介

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工作经历

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γ-glutamyl carboxylase inhibition by Anisindione

由安尼辛二酮介导的γ-谷氨酰羧化酶抑制

Structure

IF4.3

2026-08-270

PRE

Structural and functional insights into g-glutamyl carboxylase-factor IX interaction: implications for vitamin K-dependent bleeding disorders

结构与功能洞察：γ-谷氨酰羧化酶-因子IX相互作用及其对维生素K依赖性出血障碍的影响

Haematologica

IF7.9

2026-02-010

Molecular Mechanisms of Factor IX Signal Peptide and Propeptide Mutations Underlying Hemophilia B

血友病B中因子IX信号肽和前肽突变的分子机制

Thrombosis and Haemostasis

IF4.3

2026-02-010

PRE

Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy

小分子抑制γ-谷氨酰羧化酶揭示了一种新型抗凝策略

Blood Advances

IF7.1

2025-12-240

OAAI

Selective targeting of coagulation factor X Gla domain by negatively charged gold nanoparticles: a novel method for controlled antithrombotic therapy

负电金纳米粒子选择性靶向凝血因子X的Gla结构域：一种可控抗血栓治疗的新方法

Materials Today Bio

IF10.2

2025-10-010

OAAI

Molecular insights into the comorbidity of vitamin K-dependent clotting factor deficiency and chondrodysplasia punctata

维生素K依赖性凝血因子缺乏与点状软骨发育不全共病性的分子机制研究

Journal of Thrombosis and Haemostasis

IF5

2025-08-260

PRE

Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B

导致血友病B的FIX信号肽中致病变体的多模式机制

BLOOD ADVANCES

IF7.1

2024-07-240

OAAI

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2023-11-015

OAAI

Synthesis of new vitamin K derivatives with a ketone group at the C-1 ' position of the side chain and their conversion to menaquinone-4

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2023-03-010

OAAI

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

NATURE COMMUNICATIONS

IF15.7

2023-02-1438

OAAI

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation

FEBS JOURNAL

IF4.2

2021-12-012

OAAI

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2021-03-0113

OAAI

Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study

HAEMATOLOGICA

IF7.9

2019-10-1720

OAAI

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement

环辛四烯: 一种生物活性的古巴范式补体

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2019-01-2530

OAAI

Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions

SCIENTIFIC REPORTS

IF3.9

2017-12-157

OAAI

Splice-Site Mutation of Exon 3 Deletion in the Gamma-Glutamyl Carboxylase Gene Causes Inactivation of the Enzyme

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2016-11-016

OAAI

Structural and functional insights into enzymes of the vitamin K cycle

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2016-02-0188

OAAI

Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 ( VKORC1L1) Are Involved in Its Active Site Regeneration

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-03-0126

OAAI

Membrane topology for human vitamin K epoxide reductase

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2014-01-0110

OAAI

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2013-08-0155

OAAI

Jian-Ke Tie

个人简介

教育背景

工作经历

荣誉奖项

研究方向