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科言猫学术研究的AI总结
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P

Pınar Akçakaya

AstraZeneca
H指数:15
被引数:1,726

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Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes

单细胞和活体分析揭示CRISPR-Cas9脱靶和转位结果的异质性与器官特异性

Nature Communications
IF15.7
2026-08-260
OAAI
Alexandra Madsen; Niklas Selfjord; Marta Martinez-Lage; Anna-Lena Loyd; Gavin Kurgan; Mikaela Ståhlberg; Julia Lindgren; Julia Liz Touza; Leif Wigge; Mike Firth; Karl Nordström; Joseph Collin; Daniel Jachimowicz; Bastian Schiffthaler; Inken Dillmann; Panagiotis Antoniou; Aikaterini Emmanouilidi; Jonna Hellsten; Johan Forsström; Kerstin Magnell; Ashley Jacobi; Mark Behlke; Michelle Porritt; Katja Madeyski-Bengtson; Marcello Maresca; Pinar Akcakaya
A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

一种ii-b型Cas9核酸酶，在体内具有最小化的脱靶和减少的染色体易位

NATURE COMMUNICATIONS
IF15.7
2023-09-063
OAAI
Bestas, Burcu; Wimberger, Sandra; Degtev, Dmitrii; Madsen, Alexandra; Rottner, Antje K.; Karlsson, Fredrik; Naumenko, Sergey; Callahan, Megan; Touza, Julia Liz; Francescatto, Margherita; Moller, Carl Ivar; Badertscher, Lukas; Li, Songyuan; Cerboni, Silvia; Selfjord, Niklas; Ericson, Elke; Gordon, Euan; Firth, Mike; Chylinski, Krzysztof; Taheri-Ghahfarokhi, Amir; Bohlooly-Y, Mohammad; Snowden, Mike; Pangalos, Menelaos; Nuttall, Barrett; Akcakaya, Pinar; Sienski, Grzegorz; Maresca, Marcello
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
MOLECULAR THERAPY
IF12
2021-05-0113
OAAI
Zabulica, Mihaela; Srinivasan, Raghuraman C.; Akcakaya, Pinar; Allegri, Gabriella; Bestas, Burcu; Firth, Mike; Hammarstedt, Christina; Jakobsson, Tomas; Jakobsson, Towe; Ellis, Ewa; Jorns, Carl; Makris, Georgios; Scherer, Tanja; Rimann, Nicole; van Zuydam, Natalie R.; Gramignoli, Roberto; Forslow, Anna; Engberg, Susanna; Maresca, Marcello; Rooyackers, Olav; Thony, Beat; Haberle, Johannes; Rosen, Barry; Strom, Stephen C.

研究方向

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W
Weng‐Onn Lui
H 指数:36论文数:148被引数:4,596
C
Catharina Larsson
H 指数:76论文数:468被引数:2.2万
J
Jan Zedenius
H 指数:46论文数:203被引数:7,156
E
Erik Berglund
H 指数:37论文数:131被引数:5,578
R
Robert Bränström
H 指数:22论文数:115被引数:2,021
S
Stefano Caramuta
H 指数:19论文数:57被引数:2,091
D
Deniz M. Özata
H 指数:20论文数:45被引数:2,918
M
Mehran Ghaderi
H 指数:26论文数:96被引数:1,871
M
Marcello Maresca
H 指数:26论文数:79被引数:3,159
D
David Berglund
H 指数:20论文数:67被引数:1,636