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Nikolaus Stiefl

global discovery chemistry, novartis biomedical research, novartis campus, ch-4002 basel, switzerland

26H指数
69论文数
2.5K被引数
收录论文 36
发表时间
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Discovery and Characterization of Zilurgisertib; a Potent and Selective Inhibitor of Activin Receptor-like Kinase-2 (ALK2) for the Treatment of Fibrodysplasia Ossificans ProgressivaZilurgisertib的发现与表征；一种用于治疗进行性纤维发育不良性骨化（Fibrodysplasia Ossificans Progressiva）的强效且选择性激活素受体样激酶-2（ALK2）抑制剂
errACS Medicinal Chemistry Letters
IF4
err2025-10-31
err0
PREAI
errThomas Ullrich; Sabine Guth; Luca Arista; Sven Weiler; Nikolaus Stiefl; Sylvie Teixeira-Fouchard; Carien Dekker; Alexandra Hinniger; Victoria Head; Michaela Kneissel; Ina Kramer
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The changing landscape of medicinal chemistry optimization药物化学优化的变化格局
errNature Reviews Drug Discovery
IF101.8
err2025-07-07
err0
PREAI
errAnita Rácz; Levente M. Mihalovits; Maximilian Beckers; Nikolas Fechner; Nikolaus Stiefl; Finton Sirockin; William McCoull; Emma Evertsson; Malin Lemurell; Gergely Makara; György M. Keserű
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Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-22
err2
PREAI
errMackay, Angela; Velcicky, Juraj; Gommermann, Nina; Mattes, Henri; Janser, Philipp; Wright, Michael; Dubois, Celine; Brenneisen, Silke; Ilic, Slavica; Vangrevelinghe, Eric; Stiefl, Nikolaus; Boettcher, Andreas; Schoenboerner, Michel; Vogelsanger, Melanie; Muller-Bentz, Sophie; Kamke, Marion; Rubert, Joelle; Kauffmann, Muriel; Desrayaud, Sandrine; Trunzer, Markus; Srinivas, Honnappa; Hinniger, Alexandra; von Burg, Nicole; Beltz, Karen; Dekker, Carien; Farady, Christopher J.
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Balancing Molecular Size, Activity, Permeability, and Other Properties: Drug Candidates in the Context of Their Chemical Structure Optimization
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-08-13
err0
PREAI
errBeckers, Maximilian; Sirockin, Finton; Fechner, Nikolas; Stiefl, Nikolaus
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Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors发现有效的口服生物可利用的三环NLRP3抑制剂
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-01-04
err14
PREAI
errVelcicky, Juraj; Janser, Philipp; Gommermann, Nina; Brenneisen, Silke; Ilic, Slavica; Vangrevelinghe, Eric; Stiefl, Nikolaus; Boettcher, Andreas; Arnold, Christelle; Malinverni, Claire; Dawson, Janet; Murgasova, Renata; Desrayaud, Sandrine; Beltz, Karen; Hinniger, Alexandra; Dekker, Carien; Farady, Christopher J.; Mackay, Angela
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SIMPD: an algorithm for generating simulated time splits for validating machine learning approaches
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2023-12-11
err7
errOAAI
errLandrum, Gregory A.; Beckers, Maximilian; Lanini, Jessica; Schneider, Nadine; Stiefl, Nikolaus; Riniker, Sereina
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Extracting medicinal chemistry intuition via preference machine learning
errNATURE COMMUNICATIONS
IF15.7
err2023-10-31
err6
errOAAI
errChoung, Oh-Hyeon; Vianello, Riccardo; Segler, Marwin; Stiefl, Nikolaus; Jimenez-Luna, Jose
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Prediction of Small-Molecule Developability Using Large-Scale In Silico ADMET Models
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-10
err7
PREAI
errBeckers, Maximilian; Sturm, Noe; Sirockin, Finton; Fechner, Nikolas; Stiefl, Nikolaus
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PREFER: A New Predictive Modeling Framework for Molecular Discovery
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-07-24
err7
PREAI
errLanini, Jessica; Santarossa, Gianluca; Sirockin, Finton; Lewis, Richard; Fechner, Nikolas; Misztela, Hubert; Lewis, Sarah; Maziarz, Krzysztof; Stanley, Megan; Segler, Marwin; Stiefl, Nikolaus; Schneider, Nadine
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Machine Learning for Fast, Quantum Mechanics-Based Approximation of Drug Lipophilicity
errACS OMEGA
IF4.3
err2023-01-04
err25
errOAAI
errIsert, Clemens; Kromann, Jimmy C.; Stiefl, Nikolaus; Schneider, Gisbert; Lewis, Richard A.
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25 Years of Small-Molecule Optimization at Novartis: A Retrospective Analysis of Chemical Series Evolution
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2022-11-09
err14
PREAI
errBeckers, Maximilian; Fechner, Nikolas; Stiefl, Nikolaus
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GHOST: Adjusting the Decision Threshold to Handle Imbalanced Data in Machine Learning
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2021-06-08
err92
errOAAI
errEsposito, Carmen; Landrum, Gregory A.; Schneider, Nadine; Stiefl, Nikolaus; Riniker, Sereina
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Evolution of Novartis' Small Molecule Screening Deck Design诺华小分子筛板设计的演变
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-11-03
err36
PREAI
errSchuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K.
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rdScaffoldNetwork: The Scaffold Network Implementation in RDKit
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2020-06-25
err29
PREAI
errKruger, Franziska; Stiefl, Nikolaus; Landrum, Gregory A.
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Automated Identification of Chemical Series: Classifying like a Medicinal Chemist
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2020-05-06
err8
PREAI
errKruger, Franziska; Fechner, Nikolas; Stiefl, Nikolaus
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An Artificial Intelligence Approach to Proactively Inspire Drug Discovery with Recommendations
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-02-26
err16
PREAI
errRohall, Steven L.; Auch, Lydia; Gable, Jonathan; Gora, Jacob; Jansen, Johanna; Lu, Yipin; Martin, Eric; Pancost-Heidebrecht, Margaret; Shirley, Bill; Stiefl, Nikolaus; Lindvall, Mika
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Drug Analogs from Fragment-Based Long Short-Term Memory Generative Neural Networks基于片段的长短期记忆生成神经网络的药物类似物
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2019-03-25
err42
errOAAI
errAwale, Mahendra; Sirockin, Finton; Stiefl, Nikolaus; Reymond, Jean-Louis
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X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome
errCHEMMEDCHEM
IF3.4
err2018-08-16
err29
PREAI
errKallen, Joerg; Bergsdorf, Christian; Arnaud, Bertrand; Bernhard, Mario; Brichet, Murielle; Cobos-Correa, Amanda; Elhajouji, Azeddine; Freuler, Felix; Galimberti, Ivan; Guibourdenche, Christel; Haenni, Simon; Holzinger, Sandra; Hunziker, Juerg; Izaac, Aude; Kaufmann, Markus; Leder, Lukas; Martus, Hans-Joerg; von Matt, Peter; Polyakov, Valery; Roethlisberger, Patrik; Roma, Guglielmo; Stiefl, Nikolaus; Uteng, Marianne; Lerchner, Andreas
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xMaP-An Interpretable Alignment-Free Four-Dimensional Quantitative Structure Activity Relationship Technique Based on Molecular Surface Properties and Conformer Ensembles
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2018-01-02
err9
PREAI
errDreher, Jan; Scheiber, Josef; Stiefl, Nikolaus; Baumanne, Knut
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Chemical Topic Modeling: Exploring Molecular Data Sets Using a Common Text-Mining Approach
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2017-08-09
err20
PREAI
errSchneider, Nadine; Fechner, Nikolas; Landrum, Gregory A.; Stiefl, Nikolaus
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研究方向

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