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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator Thomson, Christopher G.; Aicher, Thomas D.; Cheng, Weiwei; Du, Hongwen; Dudgeon, Crissy; Li, An-Hu; Li, Baozhong; Lightcap, Eric; Luo, Diheng; Mulvihill, Mark; Pan, Pengwei; Rahemtulla, Benjamin F.; Rigby, Alan C.; Sherborne, Bradley; Sood, Sanjeev; Surguladze, David; Talbot, Eric P. A.; Tameire, Feven; Taylor, Simon; Wang, Yi; Wojnarowicz, Paulina; Xiao, Fenfen; Ramurthy, Savithri 分享 收藏
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors Stokes, Michael E.; Calvo, Veronica; Fujisawa, Sho; Dudgeon, Crissy; Huang, Sharon; Ballal, Nupur; Shen, Leyi; Gasparek, Jennifer; Betzenhauser, Matthew; Taylor, Simon J.; Staschke, Kirk A.; Rigby, Alan C.; Mulvihill, Mark J.; Bose, Nandita; Lightcap, Eric S.; Surguladze, David 分享 收藏
Repurposing the Ordering of Routine Laboratory Tests in Hospitalised Medical Patients (RePORT): results of a cluster randomised stepped-wedge quality improvement study Ambasta, Anshula; Omodon, Onyebuchi; Herring, Alyssa; Ferrie, Leah; Pokharel, Surakshya; Mehta, Ashi; Liu, Liberty; Hews-Girard, Julia; Tam, Cheuk; Taylor, Simon; Lonergan, Kevin; Faris, Peter; Duncan, Diane; Woodhouse, Douglas 分享 收藏
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R.; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A.; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W.; Liverton, Nigel; Renzetti, Louis M.; Taylor, Simon; Watt, Gillian F.; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T.; Foley, Michael A.; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J.; Bernt, Kathrin M.; Wan, Liling 分享 收藏
Measurement of spin density matrix elements in Λ(1520) photoproduction at 8.2-8.8 GeV Adhikari, S.; Akondi, C. S.; Albrecht, M.; Ali, A.; Amaryan, M.; Asaturyan, A.; Austregesilo, A.; Baldwin, Z.; Barbosa, F.; Barlow, J.; Barriga, E.; Barsotti, R.; Beattie, T. D.; Berdnikov, V. V.; Black, T.; Boeglin, W.; Briscoe, W. J.; Britton, T.; Brooks, W. K.; Chudakov, E.; Cole, S.; Cole, P. L.; Cortes, O.; Crede, V; Dalton, M. M.; Daniels, T.; Deur, A.; Dobbs, S.; Dolgolenko, A.; Dotel, R.; Dugger, M.; Dzhygadlo, R.; Egiyan, H.; Erbora, T.; Ernst, A.; Eugenio, P.; Fanelli, C.; Fegan, S.; Fitches, J.; Foda, A. M.; Furletov, S.; Gan, L.; Gao, H.; Gasparian, A.; Gleason, C.; Goetzen, K.; Goryachev, V. S.; Guo, L.; Hagen, M.; Hakobyan, H.; Hamdi, A.; Hernandez, J.; Hoffman, N. D.; Hou, G.; Huber, G. M.; Hurley, A.; Ireland, D. G.; Ito, M. M.; Jaegle, I; Jarvis, N. S.; Jones, R. T.; Kakoyan, V; Kalicy, G.; Kamel, M.; Khachatryan, V; Khatchatryan, M.; Kourkoumelis, C.; Kuleshov, S.; LaDuke, A.; Larin, I; Lawrence, D.; Lersch, D., I; Li, H.; Li, W. B.; Liu, B.; Livingston, K.; Lolos, G. J.; Luckas, K.; Lyubovitskij, V; Mack, D.; Mahmood, A.; Marukyan, H.; Matveev, V; McCaughan, M.; McCracken, M.; Meyer, C. A.; Miskimen, R.; Mitchell, R. E.; Mizutani, K.; Neelamana, V; Nerling, F.; Ng, L.; Ostrovidov, A., I; Papandreou, Z.; Paudel, C.; Pauli, P.; Pedroni, R.; Pentchev, L.; Peters, K. J.; Reinhold, J.; Ritchie, B. G.; Ritman, J.; Rodriguez, G.; Romanov, D.; Romero, C.; Saldana, K.; Salgado, C.; Schadmand, S.; Schertz, A. M.; Schick, A.; Schmidt, A.; Schumacher, R. A.; Schwiening, J.; Sharp, P.; Shen, X.; Shepherd, M. R.; Smith, A.; Smith, E. S.; Sober, D., I; Somov, A.; Somov, S.; Soto, O.; Stevens, J. R.; Strakovsky, I. I.; Sumner, B.; Suresh, K.; Tarasov, V. V.; Taylor, S.; Teymurazyan, A.; Thiel, A.; Vasileiadis, G.; Viducic, T.; Whitlatch, T.; Wickramaarachchi, N.; Williams, M.; Yang, Y.; Zarling, J.; Zhang, Z.; Zhao, Z.; Zhou, J.; Zhou, X.; Zhou, Q.; Zihlmann, B.; Glazier, D., I; Mathieu, V 分享 收藏
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate Humphreys, Philip G.; Atkinson, Stephen J.; Bamborough, Paul; Bit, Rino A.; Chung, Chun-Wa; Craggs, Peter D.; Cutler, Leanne; Davis, Rob; Ferrie, Alan; Gong, GangLi; Gordon, Laurie J.; Gray, Matthew; Harrison, Lee A.; Hayhow, Thomas G.; Haynes, Andrea; Henley, Nick; Hirst, David J.; Holyer, Ian D.; Lindon, Matthew J.; Lovatt, Cerys; Lugo, David; McCleary, Scott; Molnar, Judit; Osmani, Qendresa; Patten, Chris; Preston, Alex; Rioja, Inmaculada; Seal, Jonathan T.; Smithers, Nicholas; Sun, Fenglai; Tang, Dalin; Taylor, Simon; Theodoulou, Natalie H.; Thomas, Clare; Watson, Robert J.; Wellaway, Christopher R.; Zhu, Linrong; Tomkinson, Nicholas C. O.; Prinjha, Rab K. 分享 收藏
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Chemical shielding of H2O and HF encapsulated inside a C60 cage Jarvis, Samuel P.; Sang, Hongqian; Junqueira, Filipe; Gordon, Oliver; Hodgkinson, Jo E. A.; Saywell, Alex; Rahe, Philipp; Mamone, Salvatore; Taylor, Simon; Sweetman, Adam; Leaf, Jeremy; Duncan, David A.; Lee, Tien-Lin; Thakur, Pardeep K.; Hoffman, Gabriella; Whitby, Richard J.; Levitt, Malcolm H.; Held, Georg; Kantorovich, Lev; Moriarty, Philip; Jones, Robert G. 分享 收藏
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression Jones, Katherine L.; Beaumont, Dominic M.; Bernard, Sharon G.; Bit, Rino A.; Campbell, Simon P.; Chung, Chun-wa; Cutler, Leanne; Demont, Emmanuel H.; Dennis, Kate; Gordon, Laurie; Gray, James R.; Haase, Michael, V; Lewis, Antonia J.; McCleary, Scott; Mitchell, Darren J.; Moore, Susanne M.; Parr, Nigel; Robb, Olivia J.; Smithers, Nicholas; Soden, Peter E.; Suckling, Colin J.; Taylor, Simon; Walker, Ann L.; Watson, Robert J.; Prinjha, Rab K. 分享 收藏
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors Lucas, Simon C. C.; Atkinson, Stephen J.; Chung, Chun-Wa; Davis, Rob; Gordon, Laurie; Grandi, Paola; Gray, James J. R.; Grimes, Thomas; Phillipou, Alexander; Preston, Alex G.; Prinjha, Rab K.; Rioja, Inmaculada; Taylor, Simon; Tomkinson, Nicholas C. O.; Wall, Ian; Watson, Robert J.; Woolven, James; Demont, Emmanuel H. 分享 收藏
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors Seal, Jonathan T.; Atkinson, Stephen J.; Bamborough, Paul; Bassil, Anna; Chung, Chun-Wa; Foley, James; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Kruger, Ryan G.; Matteo, Jeanne J.; McCabe, Michael T.; Messenger, Cassie; Mitchell, Darren; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Wyce, Anastasia; Zhang, Xi-Ping; Demont, Emmanuel H. 分享 收藏
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit Rianjongdee, Francesco; Atkinson, Stephen J.; Chung, Chun-Wa; Grandi, Paola; Gray, James R. J.; Kaushansky, Laura J.; Medeiros, Patricia; Messenger, Cassie; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Satz, Alexander L.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Yao, Gang; Demont, Emmanuel H. 分享 收藏
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins Harrison, Lee A.; Atkinson, Stephen J.; Bassil, Anna; Chung, Chun-wa; Grandi, Paola; Gray, James R. J.; Levernier, Etienne; Lewis, Antonia; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jonathan T.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H. 分享 收藏
Measurement of beam asymmetry for π-Δ++ photoproduction on the proton at Eγ=8.5 GeV Adhikari, S.; Akondi, C. S.; Ali, A.; Amaryan, M.; Asaturyan, A.; Austregesilo, A.; Baldwin, Z.; Barbosa, F.; Barlow, J.; Barriga, E.; Barsotti, R.; Beattie, T. D.; Berdnikov, V. V.; Black, T.; Boeglin, W.; Briscoe, W. J.; Britton, T.; Brooks, W. K.; Cannon, B. E.; Chudakov, E.; Cole, S.; Cortes, O.; Crede, V; Dalton, M. M.; Daniels, T.; Deur, A.; Dobbs, S.; Dolgolenko, A.; Dotel, R.; Dugger, M.; Dzhygadlo, R.; Egiyan, H.; Erbora, T.; Ernst, A.; Eugenio, P.; Fanelli, C.; Fegan, S.; Fitches, J.; Foda, A. M.; Furletov, S.; Gan, L.; Gao, H.; Gasparian, A.; Gleason, C.; Goetzen, K.; Goryachev, V. S.; Guo, L.; Hakobyan, H.; Hamdi, A.; Huber, G. M.; Hurley, A.; Ireland, D. G.; Ito, M. M.; Jaegle, I; Jarvis, N. S.; Jones, R. T.; Kakoyan, V; Kalicy, G.; Kamel, M.; Khachatryan, V; Khatchatryan, M.; Kourkoumelis, C.; Kuleshov, S.; LaDuke, A.; Larin, I; Lawrence, D.; Lersch, D., I; Li, H.; Li, W. B.; Liu, B.; Livingston, K.; Lolos, G. J.; Luckas, K.; Lyubovitskij, V; Mack, D.; Marukyan, H.; Matveev, V; McCaughan, M.; McCracken, M.; McGinley, W.; Meyer, C. A.; Miskimen, R.; Mitchell, R. E.; Mizutani, K.; Neelamana, V; Nerling, F.; Ng, L.; Ostrovidov, A., I; Papandreou, Z.; Paudel, C.; Pauli, P.; Pedroni, R.; Pentchev, L.; Peters, K. J.; Phelps, W.; Pooser, E.; Reinhold, J.; Ritchie, B. G.; Ritman, J.; Rodriguez, G.; Romanov, D.; Romero, C.; Salgado, C.; Schadmand, S.; Schertz, A. M.; Schick, A.; Schumacher, R. A.; Schwiening, J.; Shen, X.; Shepherd, M. R.; Smith, A.; Smith, E. S.; Sober, D., I; Somov, A.; Somov, S.; Soto, O.; Stevens, J. R.; Strakovsky, I. I.; Sumner, B.; Suresh, K.; Tarasov, V. V.; Taylor, S.; Teymurazyan, A.; Thiel, A.; Vasileiadis, G.; Whitlatch, T.; Wickramaarachchi, N.; Williams, M.; Yang, Y.; Zarling, J.; Zhang, Z.; Zhao, Z.; Zhou, J.; Zhou, Q.; Zhou, X.; Zihlmann, B. 分享 收藏
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype Wellaway, Christopher R.; Bamborough, Paul; Bernard, Sharon G.; Chung, Chun-wa; Craggs, Peter D.; Cutler, Leanne; Demont, Emmanuel H.; Evans, John P.; Gordon, Laurie; Karamshi, Bhumika; Lewis, Antonia J.; Lindon, Matthew J.; Mitchell, Darren J.; Rioja, Inmaculada; Soden, Peter E.; Taylor, Simon; Watson, Robert J.; Willis, Rob; Woolven, James M.; Wyspianska, Beata S.; Kerr, William J.; Prinjha, Rab K. 分享 收藏
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor Seal, Jonathan T.; Atkinson, Stephen J.; Aylott, Helen; Bamborough, Paul; Chung, Chun-wa; Copley, Royston C. B.; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Hayhow, Thomas G.; Lindon, Matthew; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H. 分享 收藏
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins Preston, Alex; Atkinson, Stephen; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Gordon, Laurie; Grandi, Paola; Gray, James R. J.; Jones, Emma J.; Lindon, Matthew; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rianjongdee, Francesco; Rioja, Inmaculada; Seal, Jonathan; Taylor, Simon; Wall, Ian; Watson, Robert J.; Woolven, James; Demont, Emmanuel H. 分享 收藏
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family Preston, Alex; Atkinson, Stephen J.; Bamborough, Paul; Chung, Chun-wa; Gordon, Laurie J.; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Lewis, Antonia J.; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jon; Taylor, Simon; Thesmar, Pierre; Wall, Ian D.; Watson, J.; Woolven, James M.; Demont, Emmanuel H. 分享 收藏
Measurement of the photon beam asymmetry in (γ)over-right-arrowp → K+Σ0 at Eγ=8 . 5 GeV Adhikari, S.; Ali, A.; Amaryan, M.; Austregesilo, A.; Barbosa, F.; Barlow, J.; Barriga, E.; Barsotti, R.; Beattie, T. D.; Berdnikov, V. V.; Black, T.; Boeglin, W.; Briscoe, W. J.; Britton, T.; Brooks, W. K.; Cannon, B. E.; Cao, N.; Chudakov, E.; Cole, S.; Cortes, O.; Crede, V; Dalton, M. M.; Daniels, T.; Deur, A.; Dobbs, S.; Dolgolenko, A.; Dotel, R.; Dugger, M.; Dzhygadlo, R.; Egiyan, H.; Erbora, T.; Ernst, A.; Eugenio, P.; Fanelli, C.; Fegan, S.; Foda, A. M.; Foote, J.; Frye, J.; Furletov, S.; Gan, L.; Gasparian, A.; Gleason, C.; Goetzen, K.; Goncalves, A.; Goryachev, V. S.; Guo, L.; Hakobyan, H.; Hamdi, A.; Huber, G. M.; Hurley, A.; Ireland, D. G.; Ito, M. M.; Jarvis, N. S.; Jones, R. T.; Kakoyan, V; Kalicy, G.; Kamel, M.; Kourkoumelis, C.; Kuleshov, S.; Larin, I; Lawrence, D.; Lersch, D., I; Li, H.; Li, W.; Liu, B.; Livingston, K.; Lolos, G. J.; Lyubovitskij, V; Mack, D.; Marukyan, H.; Matveev, V; McCaughan, M.; McCracken, M.; McGinley, W.; Meyer, C. A.; Miskimen, R.; Mitchell, R. E.; Nerling, F.; Ng, L.; Ni, H.; Ostrovidov, A., I; Papandreou, Z.; Patsyuk, M.; Paudel, C.; Pauli, P.; Pedroni, R.; Pentchev, L.; Peters, K. J.; Phelps, W.; Pooser, E.; Qin, N.; Reinhold, J.; Ritchie, B. G.; Robison, L.; Romanov, D.; Romero, C.; Salgado, C.; Schertz, A. M.; Schumacher, R. A.; Schwiening, J.; Seth, K. K.; Shen, X.; Shepherd, M. R.; Smith, E. S.; Sober, D., I; Somov, A.; Somov, S.; Soto, O.; Stevens, J. R.; Strakovsky, I. I.; Suresh, K.; Tarasov, V. V.; Taylor, S.; Teymurazyan, A.; Thiel, A.; Vasileiadis, G.; Whitlatch, T.; Wickramaarachchi, N.; Williams, M.; Xiao, T.; Yang, Y.; Zarling, J.; Zhang, Z.; Zhou, Q.; Zhou, X.; Zihlmann, B. 分享 收藏
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