Nikolai Lorenzen

Novo Nordisk

17H指数

35论文数

1.3K被引数

收录论文 14

发表时间

Prediction of antibody non-specificity using protein language models and biophysical parameters 利用蛋白质语言模型和生物物理参数预测抗体非特异性

mAbs

IF7.3

2026-05-27

OAAI

Laila I. Sakhnini; Ludovica Beltrame; Simone Fulle; Pietro Sormanni; Anette Henriksen; Nikolai Lorenzen; Michele Vendruscolo; Daniele Granata

A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs

MABS

IF7.3

2024-10-04

OAAI

Condado-Morales, Itzel; Dingfelder, Fabian; Waibel, Isabel; Turnbull, Oliver M.; Patel, Bhargav; Cao, Zheng; Bjelke, Jais Rose; Grell, Susanne Nedergaard; Bennet, Anja; Hummer, Alissa M.; Raybould, Matthew I. J.; Deane, Charlotte M.; Egebjerg, Thomas; Lorenzen, Nikolai; Arosio, Paolo

Nonspecificity fingerprints for clinical-stage antibodies in solution

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-12-18

OAAI

Herling, Therese W.; Invernizzi, Gaetano; Ausserwoeger, Hannes; Bjelke, Jais Rose; Egebjerg, Thomas; Lund, Soren; Lorenzen, Nikolai; Knowlesa, Tuomas P. J.

Surface patches induce nonspecific binding and phase separation of antibodies

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-04-03

OAAI

Ausserwoeger, Hannes; Krainer, Georg; Welsh, Timothy J.; Thorsteinson, Nels; de Csillery, Ella; Sneideris, Tomas; Schneider, Matthias M.; Egebjerg, Thomas; Invernizzi, Gaetano; Herling, Therese W.; Lorenzen, Nikolai; Knowles, Tuomas P. J.

Multidimensional Protein Solubility Optimization with an Ultrahigh- Throughput Microfluidic Platform

ANALYTICAL CHEMISTRY

IF6.7

2023-03-17

OAAI

Erkamp, Nadia A.; Oeller, Marc; Sneideris, Tomas; Ausserwoger, Hannes; Levin, Aviad; Welsh, Timothy J.; Qi, Runzhang; Qian, Daoyuan; Lorenzen, Nikolai; Zhu, Hongjia; Sormanni, Pietro; Vendruscolo, Michele; Knowles, Tuomas P. J.

Non-specificity as the sticky problem in therapeutic antibody development

NATURE REVIEWS CHEMISTRY

IF51.7

2022-11-14

PREAI

Ausserwoger, Hannes; Schneider, Matthias M.; Herling, Therese W.; Arosio, Paolo; Invernizzi, Gaetano; Knowles, Tuomas P. J.; Lorenzen, Nikolai

Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2021-03-01

PREAI

Narayanan, Harini; Dingfelder, Fabian; Butte, Alessandro; Lorenzen, Nikolai; Sokolov, Michael; Arosio, Paolo

Screening for protein-protein interactions with asymmetrical flow field-flow fractionation

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-02-01

PREAI

Wahlund, Per-Olof; Lorenzen, Nikolai; Rischel, Christian

An accelerated surface-mediated stress assay of antibody instability for developability studies

MABS

IF7.3

2020-09-20

OAAI

Kopp, Marie R. G.; Perez, Adriana-Michelle Wolf; Zucca, Marta Virginia; Palmiero, Umberto Capasso; Friedrichsen, Brigitte; Lorenzen, Nikolai; Arosio, Paolo

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

MABS

IF7.3

2019-01-18

OAAI

Perez, Adriana-Michelle Wolf; Sormanni, Pietro; Andersen, Jonathan Sonne; Sakhnini, Laila Ismail; Rodriguez-Leon, Ileana; Bjelke, Jais Rose; Gajhede, Annette Juhl; De Maria, Leonardo; Otzen, Daniel E.; Vendruscolo, Michele; Lorenzen, Nikolai

Antibodies against the C-terminus of α-synuclein modulate its fibrillation

BIOPHYSICAL CHEMISTRY

IF2.2

2017-01-01

PREAI

Sahin, Cagla; Lorenzen, Nikolai; Lemminger, Lasse; Christiansen, Gunna; Moller, Ian Max; Vesterager, Louise Buur; Pedersen, Lars Ostergaard; Fog, Karina; Kallunki, Pekka; Otzen, Daniel E.

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2014-02-28

223

PREAI

Lorenzen, Nikolai; Nielsen, Soren Bang; Buell, Alexander K.; Kaspersen, Jorn Dovling; Arosio, Paolo; Vad, Brian Stougaard; Paslawski, Wojciech; Christiansen, Gunna; Valnickova-Hansen, Zuzana; Andreasen, Maria; Enghild, Jan J.; Pedersen, Jan Skov; Dobson, Christopher M.; Knowles, Tuomas P. J.; Otzen, Daniel Erik

Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth

BIOPHYSICAL JOURNAL

IF3.1

2012-05-01

OAAI

Lorenzen, Nikolai; Cohen, Samuel I. A.; Nielsen, Soren B.; Herling, Therese W.; Christiansen, Gunna; Dobson, Christopher M.; Knowles, Tuomas P. J.; Otzen, Daniel

Bayesian Optimization for Efficient Multiobjective Formulation Development of Biologics 贝叶斯优化在高效多目标生物制剂配方开发中的应用

Molecular Pharmaceutics

IF4.5

OAAI

Isabel Waibel; Timo N. Schneider; Fiona J. Fischer; Poonpat Dumnoenchanvanit; Alina Kulakova; Tin Duy Nguyen; Thomas Egebjerg; Søren Bertelsen; Nikolai Lorenzen; Paolo Arosio

研究方向