Paul Fernyhough - Publications, H-index & Citations

Paul Fernyhough

st. boniface hospital

53H指数

192论文数

7.9K被引数

收录论文 63

发表时间

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions 微生物代谢物刺激的苦味受体T2R14信号受CFTR相互作用调控

the faseb journal

IF0

2026-05-29

OAAI

Tejas Gupte; Nisha Singh; Vikram Bhatia; Kavisha Arora; Shayan Amiri; Paul Fernyhough; Anjaparavanda P. Naren; Shyamala Dakshinamurti; Prashen Chelikani

Antimuscarinic drugs exert β-arrestin–biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis 抗毒蕈碱药物在毒蕈碱乙酰胆碱1型受体上发挥β-arrestin–biased agonism作用以促进DRG神经突生长

Science Signaling

IF6.6

2026-03-31

PREAI

Shayan Amiri; Mohamad-Reza Aghanoori; Darrell R. Smith; T. M. Zaved Waise; Ying Lao; Asuka Inoue; René P. Zahedi; Henry A. Dunn; Paul Fernyhough

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy 在2型糖尿病伴周围神经病变患者的一项2a期研究中，抗毒蕈碱药物pirenzepine的局部应用增加了下肢神经纤维密度。

eBioMedicine

IF10.8

2025-12-05

OAAI

Ajith Sivadasan; Paul Fernyhough; Nigel A. Calcutt; Katie E. Frizzi; Kimberly Gardner; Angela Hansen; Ari Breiner; Douglas W. Zochodne; Natalia McInnes; Zubin Punthakee; Sylvie Gosselin; Bruce A. Perkins; Vera Bril

Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons 雌二醇通过激活CaMKKβ/AMPK通路来增强体外培养的成年感觉神经元轴突生长。

MOLECULAR AND CELLULAR NEUROSCIENCE

IF2.4

2025-06-01

OAAI

Mishra, Pranav; Albensi, Benedict C.; Fernyhough, Paul

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons

MOLECULAR METABOLISM

IF6.6

2025-02-01

OAAI

Chauhan, Sanjana; Smith, Darrell R.; Shariati-Ievari, Shiva; Srivastava, Abhay; Dhingra, Sanjiv; Aliani, Michel; Fernyhough, Paul

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin

ACTA NEUROPATHOLOGICA

IF9.3

2024-03-25

PREAI

Casselini, Carolina M.; Parson, Henri K.; Frizzi, Katie E.; Marquez, Alex; Smith, Darrell R.; Guernsey, Lucie; Nemmani, Rakesh; Tayarani, Alireza; Jolivalt, Corinne G.; Weaver, Jessica; Fernyhough, Paul; Vinik, Aaron I.; Calcutt, Nigel A.

Oxidative Stress and Mitochondrial Dysfunction Associated with Peripheral Neuropathy in Type 1 Diabetes

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2022-09-01

PREAI

Eftekharpour, Eftekhar; Fernyhough, Paul

Enhancement of Mitochondrial Function by the Neurogenic Molecule NSI-189 Accompanies Reversal of Peripheral Neuropathy and Memory Impairment in a Rat Model of Type 2 Diabetes

JOURNAL OF DIABETES RESEARCH

IF3.4

2022-07-04

OAAI

Jolivalt, C. G.; Aghanoori, M. R.; Navarro-Diaz, M. C.; Han, M. M.; Sanchez, G.; Guernsey, L.; Quach, D.; Johe, K.; Fernyhough, P.; Calcutt, N. A.

Development of iPSC-based clinical trial selection platform for patients with ultrarare diseases

SCIENCE ADVANCES

IF12.5

2022-04-08

OAAI

Sequiera, Glen Lester; Srivastava, Abhay; Sareen, Niketa; Yan, Weiang; Alagarsamy, Keshav Narayan; Verma, Elika; Aghanoori, Mohamad Reza; Aliani, Michel; Kumar, Ashok; Fernyhough, Paul; Rockman-Greenberg, Cheryl; Dhingra, Sanjiv

CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth 可以动员cebp β 调节成年感觉神经元的内源性IGF-1，以克服糖尿病引起的生物能学和轴突生长缺陷

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2022-03-17

OAAI

Aghanoori, Mohamad-Reza; Agarwal, Prasoon; Gauvin, Evan; Nagalingam, Raghu S.; Bonomo, Raiza; Yathindranath, Vinith; Smith, Darrell R.; Hai, Yan; Lee, Samantha; Jolivalt, Corinne G.; Calcutt, Nigel A.; Jones, Meaghan J.; Czubryt, Michael P.; Miller, Donald W.; Dolinsky, Vernon W.; Mansuy-Aubert, Virginie; Fernyhough, Paul

Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

MOLECULAR METABOLISM

IF6.6

2021-07-01

OAAI

Aghanoori, Mohamad-Reza; Margulets, Vicky; Smith, Darrell R.; Kirshenbaum, Lorrie A.; Gitler, Daniel; Fernyhough, Paul

Selective or Specific M1 Muscarinic Receptor Antagonists Exhibit Biased Agonism at the M1 Receptor via β-arrestin Signaling

FASEB JOURNAL

IF4.2

2021-05-14

PREAI

Amiri, Shayan; Aghanoori, Mohamad-Reza; Fernyhough, Paul

Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system

EXPERT REVIEW OF NEUROTHERAPEUTICS

IF3.4

2020-12-04

OAAI

Demare, Sarah; Kothari, Asha; Calcutt, Nigel A.; Fernyhough, Paul

Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease

NUTRIENTS

IF5

2020-11-23

OAAI

Snow, Wanda M.; Cadonic, Chris; Cortes-Perez, Claudia; Adlimoghaddam, Aida; Chowdhury, Subir K. Roy; Thomson, Ella; Anozie, Adama; Bernstein, Michael J.; Gough, Kathleen; Fernyhough, Paul; Suh, Miyoung; Albensi, Benedict C.

Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2020-07-01

OAAI

Jolivalt, Corinne G.; Frizzi, Katie E.; Han, May Madi; Mota, Andre J.; Guernsey, Lucie S.; Kotra, Lakshmi P.; Fernyhough, Paul; Calcutt, Nigel A.

Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer's Mice

CELLS

IF5.2

2020-06-24

OAAI

Djordjevic, Jelena; Chowdhury, Subir Roy; Snow, Wanda M.; Perez, Claudia; Cadonic, Chris; Fernyhough, Paul; Albensi, Benedict C.

Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189

DIABETES

IF7.5

2019-09-06

OAAI

Jolivalt, Corinne G.; Marquez, Alexandra; Quach, David; Diaz, Michelle C. Navarro; Anaya, Carlos; Kifle, Betelhem; Muttalib, Nabeel; Sanchez, Gabriela; Guernsey, Lucy; Hefferan, Mike; Smith, Darrel R.; Fernyhough, Paul; Johe, Karl; Calcutt, Nigel A.

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

MOLECULAR METABOLISM

IF6.6

2019-02-01

OAAI

Aghanoori, Mohamad-Reza; Smith, Darrell R.; Shariati-Ievari, Shiva; Ajisebutu, Andrew; Nguyen, Annee; Desmond, Fiona; Jesus, Carlos H. A.; Zhou, Xiajun; Calcutt, Nigel A.; Aliani, Michel; Fernyhough, Paul

iPSC based multisystemic-disease models from patients of mitochondrial disorder display varied disease progression in different cell types

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2018-11-01

PREAI

Sequiera, Glen Lester; Sareen, Niketa; Aghanoori, Mohamad Reza; Mangat, Sandeep; Sidhu, Prince; Abu-El Rub, Ejlal; Moudgil, Meenal; Fernyhough, Paul; Rockman-Greenberg, Cheryl; Dhingra, Sanjiv

Muscarinic Receptor Antagonist Improves Nerve Fiber Function in Subjects with Type 2 Diabetes and Peripheral Neuropathy

DIABETES

IF7.5

2018-07-01

PREAI

Vinik, Aaron I.; Calcutt, Nigel A.; Edwards, Joshua F.; Weaver, Jessica R.; Bailey, Michael D.; Fernyhough, Paul; Cundra, Lindsey B.; Frizzi, Katie E.; Parson, Henri; Casellini, Carolina M.

研究方向