Jared S. Bee

University of Colorado System

H指数:22

被引数:2,011

个人简介

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教育背景

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工作经历

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荣誉奖项

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Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events

PHARMACEUTICAL RESEARCH

IF4.3

2023-03-031

PRE

Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing Mechanisms of Freeze/Thaw Induced AAV Rupture

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2022-07-0113

OAAI

Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2022-05-0112

OAAI

Development of a stable lyophilized adeno-associated virus gene therapy formulation

稳定冻干腺相关病毒基因治疗制剂的研制

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2021-09-0114

PRE

Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-09-0118

OAAI

Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures

单克隆抗体特异性可逆自缔合的能量解剖揭示了独特的热力学特征

PHARMACEUTICAL RESEARCH

IF4.3

2021-02-183

PREAI

Analytical characterization of coformulated antibodies as combination therapy

MABS

IF7.3

2020-03-2122

OAAI

Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model

在小鼠模型中，通过低pH，热或光照诱导的单克隆抗体二聚体在皮下给药时没有免疫原性

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2020-01-0111

OAAI

Investigation of cathepsin D-mAb interactions using a combined experimental and computational tool set

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2019-03-2916

PREAI

Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2018-11-0161

OAAI

Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2018-07-0117

PREAI

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-06-0155

OAAI

Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2017-04-015

PREAI

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-03-0125

OAAI

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

在小鼠中皮下注射单克隆抗体的多聚体寡聚物，亚微米和微米大小的聚集体的命运

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2016-05-0122

PREAI

Technical Decision Making with Higher Order Structure Data: Impact of a Formulation Change on the Higher Order Structure and Stability of a mAb

具有高阶结构数据的技术决策: 配方变化对mAb高阶结构和稳定性的影响

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2015-04-0113

PREAI

Gelation of a Monoclonal Antibody at the Silicone Oil-Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation

单克隆抗体在硅油-水界面处的凝胶化以及随后界面凝胶的破裂导致聚集和颗粒形成

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2015-04-0196

PREAI

Protein Aggregation and Particle Formation in Prefilled Glass Syringes

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2014-06-01167

PREAI

Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2013-02-0176

PREAI

The future of protein particle characterization and understanding its potential to diminish the immunogenicity of biopharmaceuticals: A shared perspective

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2012-10-0154

PREAI

Jared S. Bee

个人简介

教育背景

工作经历

荣誉奖项

研究方向