未登录Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity
Ni, Minghong; Parafioriti, Michela; Esposito, Emiliano; Danzi, Margherita; Cano, Ornela; Muzi, Laura; Kayal, Yasmin; Ferro, Vito; Vlodavsky, Israel; Elli, Stefano; Naggi, Annamaria; Petitou, Maurice; Guerrini, Marco
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收藏Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycansSARS-CoV-2刺突S1蛋白与细胞表面聚糖初始接触中存在多种结合模式的证据
Parafioriti, Michela; Ni, Minghong; Petitou, Maurice; Mycroft-West, Courtney J.; Rudd, Timothy R.; Gandhi, Neha S.; Ferro, Vito; Turnbull, Jeremy E.; Lima, Marcelo A.; Skidmore, Mark A.; Fernig, David G.; Yates, Edwin A.; Bisio, Antonella; Guerrini, Marco; Elli, Stefano
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收藏EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis
Alame, Ghina; Mangin, Pierre H.; Freund, Monique; Riehl, Nadia; Magnenat, Stephanie; Petitou, Maurice; Hechler, Beatrice; Gachet, Christian
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收藏Inhibition of coagulation proteases Xa and IIa decreases ischemia-reperfusion injuries in a preclinical renal transplantation model
Tillet, Solenne; Giraud, Sebastien; Kerforne, Thomas; Saint-Yves, Thibaut; Joffrion, Sandrine; Goujon, Jean-Michel; Cau, Jerome; Mauco, Gerard; Petitou, Maurice; Hauet, Thierry
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收藏Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure-Activity Relationship Studies
Roy, Sucharita; El Hadri, Ahmed; Richard, Sebastien; Denis, Fanny; Holte, Kimberly; Duffner, Jay; Yu, Fei; Galcheva-Gargova, Zoya; Capila, Ishan; Schultes, Birgit; Petitou, Maurice; Kaundinya, Ganesh V.
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收藏The Antithrombotic Activity of EP224283, a Neutralizable Dual Factor Xa Inhibitor/Glycoprotein IIbIIIa Antagonist, Exceeds That of the Coadministered Parent Compounds
Hechler, Beatrice; Freund, Monique; Alame, Ghina; Leguay, Cecile; Gaertner, Sebastien; Cazenave, Jean-Pierre; Petitou, Maurice; Gachet, Christian
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收藏Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity
Huet, Thierry; Kerbarh, Olivier; Schols, Dominique; Clayette, Pascal; Gauchet, Cecile; Dubreucq, Guy; Vincent, Loic; Bompais, Heidi; Mazinghien, Romain; Querolle, Olivier; Salvador, Arnaud; Lemoine, Jerome; Lucidi, Bruno; Balzarini, Jan; Petitou, Maurice
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收藏Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin
Dewerchin, M; Hérault, JP; Wallays, G; Petitou, M; Schaeffer, P; Millet, L; Weitz, JI; Moons, L; Collen, D; Carmeliet, P; Herbert, JM
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收藏EVIDENCE FOR CONFORMATIONAL EQUILIBRIUM OF THE SULFATED L-IDURONATE RESIDUE IN HEPARIN AND IN SYNTHETIC HEPARIN MONOSACCHARIDES AND OLIGOSACCHARIDES - NMR AND FORCE-FIELD STUDIES
FERRO, DR; PROVASOLI, A; RAGAZZI, M; TORRI, G; CASU, B; GATTI, G; JACQUINET, JC; SINAY, P; PETITOU, M; CHOAY, J
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