Howard B. Cottam

University of California San Diego

H指数:37

被引数:6,145

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Structure–Activity Relationship Studies in Substituted Oxadiazoles as Inducers of Extracellular Vesicles

取代噁二唑作为外泌体诱导剂的构效关系研究

Journal of Medicinal Chemistry

IF6.8

2026-03-120

PRE

Enhancing vaccine immunogenicity through heterologous prime-boost regimen with multiple nasal boosting with liposomal TLR7 ligand

通过异源序贯免疫策略结合多次鼻腔给予脂质体TLR7配体进行加强，以增强疫苗的免疫原性。

Vaccine

IF3.5

2025-10-080

OAAI

Design and Application of Conjugatable Small Molecule Toll-Like Receptor 4 Ligands

共轭小分子Toll样受体4配体的设计与应用

Bioconjugate Chemistry

IF3.9

2025-06-180

PRE

Structure-Activity Relationship Studies in Benzothiadiazoles as Novel Vaccine Adjuvants

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-08-080

PRE

Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses

PHARMACEUTICS

IF5.5

2024-01-133

OAAI

Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx

ACS CHEMICAL BIOLOGY

IF3.8

2023-04-113

OAAI

A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination

VACCINES

IF3.4

2022-10-113

OAAI

Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating aSynthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles onImmunostimulatory Effects

ACS CHEMICAL BIOLOGY

IF3.8

2022-03-308

PRE

Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity

小分子钙通道激活剂增强佐剂活性

ACS CHEMICAL BIOLOGY

IF3.8

2022-01-053

OAAI

Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge

佐剂活性的小分子增效剂可提高对流感病毒攻击的存活率

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-09-283

OAAI

Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-KB activation

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-08-017

OAAI

Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection

用于流感病毒感染的线粒体依赖性合成小分子疫苗佐剂

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-06-0210

A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

FRONTIERS IN IMMUNOLOGY

IF5.9

2020-06-1919

OAAI

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-10-119

OAAI

Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants

BIOCONJUGATE CHEMISTRY

IF3.9

2019-09-2719

PREAI

Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-12-0313

OAAI

Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-11-0322

OAAI

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice

合成Toll样受体4 (TLR4) 和TLR7配体通过MyD88叠加作用诱导小鼠保护性抗病毒免疫

JOURNAL OF VIROLOGY

IF3.8

2017-10-0128

OAAI

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease

在帕金森氏病小鼠模型中，低一氧化氮可减少神经炎症和 α-突触核蛋白的积累

JOURNAL OF NEUROINFLAMMATION

IF10.1

2015-12-1838

OAAI

Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides

BIOCONJUGATE CHEMISTRY

IF3.9

2015-08-0544

PREAI

Howard B. Cottam

个人简介

教育背景

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