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PD-L2 blockade elicits IL-17-induced IFNγ to treat melanoma in the aged host through CD8+T and gd T cell effects Tanner, Christopher; Ontiveros, Carlos Oscar; Murray, Clare; Leung, Bernice; Soh, Kah Teong; Krishnan, Shanmugarajan; Chand, Dhan; Turk, Mary Jo; Conejo-Garcia, Jose R.; Curiel, Tyler J. 分享 收藏
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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors 肿瘤内在的PDL1信号调节癌细胞中Chk2 DNA损伤反应并介导对Chk1抑制剂的抗性 Murray, Clare E.; Kornepati, Anand V. R.; Ontiveros, Carlos; Liao, Yiji; de la Pena Avalos, Barbara; Rogers, Cody M.; Liu, Zexuan; Deng, Yilun; Bai, Haiyan; Kari, Suresh; Padron, Alvaro S.; Boyd, Jacob T.; Reyes, Ryan; Clark, Curtis A.; Svatek, Robert S.; Li, Rong; Hu, Yanfen; Wang, Meiling; Conejo-Garcia, Jose R.; Byers, Lauren A.; Ramkumar, Kavya; Sood, Anil K.; Lee, Jung-Min; Burd, Christin E.; Vadlamudi, Ratna K.; Gupta, Harshita B.; Zhao, Weixing; Dray, Eloise; Sung, Patrick; Curiel, Tyler J. 分享 收藏
Botensilimab, an Fc-Enhanced Anti-CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy Chand, Dhan; Savitsky, David A.; Krishnan, Shanmugarajan; Mednick, Gabriel; Delepine, Chloe; Garcia-Broncano, Pilar; Soh, Kah Teong; Wu, Wei; Wilkens, Margaret K.; Udartseva, Olga; Vincent, Sylvia; Joshi, Bishnu; Keith, Justin G.; Manrique, Mariana; Marques, Marilyn; Tanne, Antoine; Levey, Daniel L.; Han, Haiyong; Ng, Serina; Ridpath, Jackson; Huber, Olivia; Morin, Benjamin; Galand, Claire; Bourdelais, Sean; Gombos, Randi B.; Ward, Rebecca; Qin, Yu; Waight, Jeremy D.; Costa, Matthew R.; Sebastian-Yague, Alvaro; Rudqvist, Nils-Petter; Pupecka-Swider, Malgorzata; Venkatraman, Vignesh; Slee, Andrew; Patel, Jaymin M.; Grossman, Joseph E.; Wilson, Nicholas S.; Von Hoff, Daniel D.; Stebbing, Justin; Curiel, Tyler J.; Buell, Jennifer S.; O'Day, Steven J.; Stein, Robert B. 分享 收藏
Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial Bullock, Andrea J.; Schlechter, Benjamin L.; Fakih, Marwan G.; Tsimberidou, Apostolia M.; Grossman, Joseph E.; Gordon, Michael S.; Wilky, Breelyn A.; Pimentel, Agustin; Mahadevan, Daruka; Balmanoukian, Ani S.; Sanborn, Rachel E.; Schwartz, Gary K.; Abou-Alfa, Ghassan K.; Segal, Neil H.; Bockorny, Bruno; Moser, Justin C.; Sharma, Sunil; Patel, Jaymin M.; Wu, Wei; Chand, Dhan; Rosenthal, Katherine; Mednick, Gabriel; Delepine, Chloe; Curiel, Tyler J.; Stebbing, Justin; Lenz, Heinz-Josef; O'Day, Steven J.; El-Khoueiry, Anthony B. 分享 收藏
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis Ebrahimi, Behnam; Viswanadhapalli, Suryavathi; Pratap, Uday P.; Rahul, Gopalam; Yang, Xue; Pitta Venkata, Prabhakar; Drel, Viktor; Santhamma, Bindu; Konda, Swapna; Li, Xiaonan; Sanchez, Alondra Lee Rodriguez; Yan, Hui; Sareddy, Gangadhara R.; Xu, Zhenming; Singh, Brij B.; Valente, Philip T.; Chen, Yidong; Lai, Zhao; Rao, Manjeet; Kost, Edward R.; Curiel, Tyler; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏
Pharmacological inhibition of the LIF-LIFR autocrine loop reveals vulnerability of ovarian cancer to ferroptosis Ebrahimi, Behnam; Viswanadhapalli, Suryavathi; Pratap, Uday P.; Gopalam, Rahul; Yang, Xue; Venkata, Prabhakar P.; Drel, Viktor; Santhamma, Bindu; Konda, Swapna; Li, Xiaonan; Sanchez, Alondra L. Rodriguez; Yan, Hui; Sareddy, Gangadhara R.; Xu, Zhenming; Singh, Brij B.; Valente, Philip T.; Chen, Yidong; Lai, Zhao; Rao, Manjeet; Kost, Edward R.; Curiel, Tyler; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏
MiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastases Krishnan, Shanmugarajan; Joshi, Bishnu; Keith, Justin; Frazier, Ryan; Kalinowska, Barbara; Choi, Jin San; Sanders, Stephanie; Boi, Shannon; Le Tonqueze, Olivier; Kushner, Nick; Soh, Kah Teong; Stein, Robert; Curiel, Tyler J.; van Dijk, Marc A.; Kim, Enoch; Chantzoura, Eleni; Rudqvist, Nils-Petter; Chand, Dhan 分享 收藏
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers 用二聚体IgA靶向细胞内癌蛋白促进从细胞质中的排出和免疫介导的上皮癌控制 Biswas, Subir; Mandal, Gunjan; Anadon, Carmen M.; Chaurio, Ricardo A.; Lopez-Bailon, Luis U.; Nagy, Mate Z.; Mine, Jessica A.; Hanggi, Kay; Sprenger, Kimberly B.; Innamarato, Patrick; Harro, Carly M.; Powers, John J.; Johnson, Joseph; Fang, Bin; Eysha, Mostafa; Nan, Xiaolin; Li, Roger; Perez, Bradford A.; Curiel, Tyler J.; Yu, Xiaoqing; Rodriguez, Paulo C.; Conejo-Garcia, Jose R. 分享 收藏
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer Disis, Mary L.; Adams, Sarah F.; Bajpai, Jyoti; Butler, Marcus O.; Curiel, Tyler; Dodt, Shelley A.; Doherty, Laura; Emens, Leisha A.; Friedman, Claire F.; Gatti-Mays, Margaret; Geller, Melissa A.; Jazaeri, Amir; John, Veena S.; Kurnit, Katherine C.; Liao, John B.; Mahdi, Hader; Mills, Anne; Zsiros, Emese; Odunsi, Kunle 分享 收藏
Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model Ontiveros, Carlos Oscar; Chen, Tiffany; Murray, Clare; Kornepati, Anand; Deng, Yilun; Blinkiewicz, Paige; Bai, Haiyan; Crossland, Grace; Souto-Padron, Alvaro; Gupta, Harshita B.; Turk, Mary Jo; Burd, Christin; Curiel, Tyler J. 分享 收藏
Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects Bai, Haiyan; Padron, Alvaro S.; Deng, Yilun; Liao, Yiji J.; Murray, Clare J.; Ontiveros, Carlos; Kari, Suresh J.; Kancharla, Aravind; Kornepati, Anand V. R.; Garcia, Myrna; Reyes, Ryan Michael; Gupta, Harshita B.; Conejo-Garcia, Jose R.; Curiel, Tyler 分享 收藏
PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer Hong, Juyeong; Lee, Ji Hoon; Zhang, Zhao; Wu, Yanming; Yang, Mei; Liao, Yiji; de la Rosa, Richard; Scheirer, Jessica; Pechacek, Douglas; Zhang, Nu; Xu, Zhenming; Curiel, Tyler; Tan, Xi; Huang, Tim H. -M.; Xu, Kexin 分享 收藏
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