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孙慧涌 封面图

孙慧涌 (Huiyong Sun)

zhejiang university

44H指数
131论文数
9.8K被引数
收录论文 78
发表时间
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The SIMDA framework maps PIP2-binding sites regulating the KCNQ1 channelSIMDA框架映射调节KCNQ1通道的PIP2结合位点
errNature Communications
IF15.7
err2026-08-22
err0
errOAAI
errLingling Wang; Shu Li; Yunsen Zhang; Huiyong Sun; Qin Li; Wei Zhao; Xiaomeng Liu; Xiao Yan; Henry H. Y. Tong; Xiaojun Yao; Huanxiang Liu
err分享
err收藏
STE-DC2I Uncovers Driver Genes in Colorectal Cancer Subtypes Using Symbolic Trajectory-Embedded Dark Causal InferenceSTE-DC2I 通过符号轨迹嵌入的暗因果推断揭示结直肠癌亚型的驱动基因
errJournal of Chemical Information and Modeling
IF5.3
err2026-05-22
err0
PREAI
errMeng Huang; Huijin Hu; Ming Li; Jian Zhang; Heng Zhang; Xiucai Ye; Tinghuai Ma; Huiyong Sun; Lei Ye; Tingjun Hou
err分享
err收藏
LaMGen: LLM-based 3D molecular generation for multi-target drug designLaMGen：基于大型语言模型的3D分子生成用于多靶点药物设计
errNature Communications
IF15.7
err2026-04-11
err0
errOAAI
errQun Su; Qiaolin Gou; Hui Zhang; Jike Wang; Huiyong Sun; Renling Hu; Rui Qin; Huanxiang Liu; Tingjun Hou; Yu Kang
err分享
err收藏
A Novel FXR-Targeted DUBTAC and Its Applications in Cholestasis Therapy一种新型的FXR靶向DUBTAC及其在胆汁淤积症治疗中的应用
errJournal of Medicinal Chemistry
IF6.8
err2026-03-20
err0
PREAI
errMing Cui; Bin Tang; Tingting Yao; Wenbin Shao; Qiuling Zheng; Huiyong Sun; Haiping Hao; Hong Wang; Xiaowei Xu
err分享
err收藏
Understanding the Kinetic Mechanism of Ligands Stabilizing the RAS–CYPA Interaction理解配体稳定RAS-CYPA相互作用的动力学机制
errJournal of Chemical Information and Modeling
IF5.3
err2026-01-22
err0
PREAI
errKexin Xu; Mingyun Shen; Zhe Wang; Sutong Xiang; Qirui Deng; Kaimo Yang; Zhiliang Jiang; Zihao Wang; Chen Yin; Tingjun Hou; Huiyong Sun
err分享
err收藏
A Composite Sponge Based on Carboxymethyl Chitosan- Panax Notoginseng Polysaccharides for Rapid Hemostasis and Wound Healing一种基于羧甲基壳聚糖-人参三七多糖的复合海绵，用于快速止血和伤口愈合
errMacromolecular Bioscience
IF4.1
err2025-10-14
err0
PREAI
errMei Zhang; Huiyong Sun; Tianci Liu; Xiangjuan Li; Yan Wang; Gaiping Du
err分享
err收藏
Harnessing deep statistical potential for biophysical scoring of protein-peptide interactions利用深度统计潜力进行蛋白质-肽相互作用生物物理打分
errActa Pharmacologica Sinica
IF8.4
err2025-10-01
err0
PREAI
errDe-jun Jiang; Hui-feng Zhao; Hong-yan Du; Yu Kang; Pei-chen Pan; Zhen-xing Wu; Yun-dian Zeng; O-din Zhang; Xiao-rui Wang; Ji-ke Wang; Yuan-sheng Huang; Yi-hao Zhao; Chang-Yu Hsieh; Dong-sheng Cao; Hui-yong Sun; Ting-jun Hou
err分享
err收藏
Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations通过计算模拟揭示的蛋白酶靶向嵌合体系统的动态特性
errCurrent Opinion in Structural Biology
IF7
err2025-09-10
err0
PREAI
errKexin Xu; Jingxuan Ge; Rongfan Tang; Tingjun Hou; Huiyong Sun
err分享
err收藏
ChargeNet: E(3) Equivariant Graph Attention Network for Atomic Charge PredictionChargeNet: E(3)等变图注意力网络用于原子电荷预测
errJournal of Chemical Information and Modeling
IF5.3
err2025-06-18
err0
PREAI
errQiaolin Gou; Qun Su; Jike Wang; Hui Zhang; Huiyong Sun; Xujun Zhang; Linlong Jiang; Meijing Fang; Yu Kang; Huanxiang Liu; Tingjun Hou; Chang-Yu Hsieh
err分享
err收藏
Development of PROTACs using computational approaches使用计算方法开发PROTACs
errTRENDS IN PHARMACOLOGICAL SCIENCES
IF19.9
err2024-12-01
err0
PREAI
errGe, Jingxuan; Hsieh, Chang-Yu; Fang, Meijing; Sun, Huiyong; Hou, Tingjun
err分享
err收藏
Dual-function natural products: Farnesoid X receptor agonist/inflammation inhibitor for metabolic dysfunction-associated steatotic liver disease therapy双功能天然产物: 法尼酯X受体激动剂/炎症抑制剂用于代谢功能障碍相关的脂肪性肝病治疗
errCHINESE JOURNAL OF NATURAL MEDICINES
IF4.9
err2024-11-01
err1
PREAI
errWang, Kang; Zhang, Pengfei; Sun, Huiyong; Cui, Shuang; Ao, Lanjia; Cui, Ming; Xu, Xiaowei; Wang, Lin; Xu, Yuanyuan; Wang, Guangji; Wang, Hong; Hao, Haiping
err分享
err收藏
Characterizing the Cooperative Effect of PROTAC Systems with End-Point Binding Free Energy Calculation用终点结合自由能计算表征PROTAC系统的协同效应
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-10-03
err2
PREAI
errXu, Kexin; Wang, Zhe; Xiang, Sutong; Tang, Rongfan; Deng, Qirui; Ge, Jingxuan; Jiang, Zhiliang; Yang, Kaimo; Hou, Tingjun; Sun, Huiyong
err分享
err收藏
PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parametersProtac-db 3.0: 具有扩展药代动力学参数的PROTACs更新数据库
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-09-03
err2
errOAAI
errGe, Jingxuan; Li, Shimeng; Weng, Gaoqi; Wang, Huating; Fang, Meijing; Sun, Huiyong; Deng, Yafeng; Hsieh, Chang- Yu; Li, Dan; Hou, Tingjun
err分享
err收藏
Elucidating the Selective Mechanism of Drugs Targeting Cyclin-Dependent Kinases with Integrated MetaD-US Simulation整合metad-us模拟阐明靶向细胞周期蛋白依赖性激酶药物的选择性机制
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-08-22
err0
PREAI
errWang, Lingling; Li, Shu; Xiang, Sutong; Liu, Huanxiang; Sun, Huiyong
err分享
err收藏
RLpMIEC: High-Affinity Peptide Generation Targeting Major Histocompatibility Complex-I Guided and Interpreted by Interaction Spectrum-Navigated Reinforcement LearningRLpMIEC: 通过相互作用谱导航的强化学习指导和解释针对主要组织相容性复合体I的高亲和力肽生成
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-08-09
err0
PREAI
errDeng, Qirui; Wang, Zhe; Xiang, Sutong; Wang, Qinghua; Liu, Yifei; Hou, Tingjun; Sun, Huiyong
err分享
err收藏
TransfIGN: A Structure-Based Deep Learning Method for Modeling the Interaction between HLA-A*02:01 and Antigen PeptidesTransfIGN: 一种基于结构的深度学习方法，用于对hla-a * 02:01与抗原肽之间的相互作用进行建模
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-06-26
err1
PREAI
errHong, Nanqi; Jiang, Dejun; Wang, Zhe; Sun, Huiyong; Luo, Hao; Bao, Lingjie; Song, Mingli; Kang, Yu; Hou, Tingjun
err分享
err收藏
Deep-learning-based prediction framework for protein-peptide interactions with structure generation pipeline基于深度学习的具有结构生成管道的蛋白质-肽相互作用预测框架
errCELL REPORTS PHYSICAL SCIENCE
IF7.3
err2024-06-01
err1
errOAAI
errGe, Jingxuan; Jiang, Dejun; Sun, Huiyong; Kang, Yu; Pan, Peichen; Deng, Yafeng; Hsieh, Chang-Yu; Hou, Tingjun
err分享
err收藏
A potent new-scaffold androgen receptor antagonist discovered on the basis of a MIEC-SVM model
errACTA PHARMACOLOGICA SINICA
IF8.4
err2024-05-15
err4
PREAI
errWang, Xin-yue; Chai, Xin; Shan, Lu-hu; Xu, Xiao-hong; Xu, Lei; Hou, Ting-jun; Sun, Hui-yong; Li, Dan
err分享
err收藏
Discovery of proqodine A derivatives with antitumor activity target-ing NAD(P)H: quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase靶向NAD(P)H的具有抗肿瘤活性的proqodine A衍生物的发现: 醌氧化还原酶1和烟酰胺磷酸核糖基转移酶
errCHINESE JOURNAL OF NATURAL MEDICINES
IF4.9
err2024-01-01
err1
PREAI
errSong, Jiangzhou; Zou, Guiqing; Zhao, Zhou; Zhu, Ya; Xue, Jiayu; Ao, Lanjia; Sun, Huiyong; Hao, Haiping; Zhang, Bo; Xu, Xiaowei
err分享
err收藏
Exhaustively Exploring the Prevalent Interaction Pathways of Ligands Targeting the Ligand-Binding Pocket of Farnesoid X Receptor via Combined Enhanced Sampling通过联合增强采样彻底探索靶向法尼酯X受体的配体结合口袋的配体的普遍相互作用途径
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-11-20
err4
PREAI
errXiang, Sutong; Wang, Zhe; Tang, Rongfan; Wang, Lingling; Wang, Qinghua; Yu, Yang; Deng, Qirui; Hou, Tingjun; Hao, Haiping; Sun, Huiyong
err分享
err收藏

研究方向

学术兼职基于人工智能技术的药物设计基于分子模拟技术的药物发现与作用机制研究Biological Modeling and SimulationFree Energy CalculationDrug Discovery新型抗耐药ALK抑制剂的分子设计及药理活性ALK抗耐药抑制剂设计计算机辅助药物设计人工智能辅助药物设计难靶靶点药物设计高精度虚拟筛选策略药物-靶标相互作用表征人工智能算法研究药物-靶标相互作用识别分子生成PROTAC系统动力学特征与降解偏好药物耐药机制结合自由能计算核受体配体结合口袋靶向配体分子类别鉴定结构解析与机器学习蛋白质-蛋白质相互作用体系的稳定化效应末端结合自由能计算蛋白质-配体相互作用突变效应预测原子电荷预测图卷积网络药物设计
合作学者
合作期刊
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秦鹂 封面图
秦鹂 (Qin Li)
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胡
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王君玫 封面图
王君玫 (Junmei Wang)
H 指数: 76 · 论文数: 751
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