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Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1 Wu, Ruoxi; Khamrui, Susmita; Dodatko, Tetyana; Leandro, Joao; Sabovic, Amanda; Violante, Sara; Cross, Justin R.; Marsan, Eric; Kumar, Kunal; Devita, Robert J.; Lazarus, Michael B.; Houten, Sander M. 分享 收藏
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Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence 衰老细胞模型的转录组与多组织患者样本的整合揭示了COL6A3作为衰老诱导剂的减少 Savic, Radoslav; Yang, Jialiang; Koplev, Simon; An, Mahru C.; Patel, Priyanka L.; O'Brien, Robert N.; Dubose, Brittany N.; Dodatko, Tetyana; Rogatsky, Eduard; Sukhavasi, Katyayani; Ermel, Raili; Ruusalepp, Arno; Houten, Sander M.; Kovacic, Jason C.; Stewart, Andrew F.; Yohn, Christopher B.; Schadt, Eric E.; Laberge, Remi-Martin; Bjorkegren, Johan L. M.; Tu, Zhidong; Argmann, Carmen 分享 收藏
Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5'-phosphate homeostasis protein Ciapaite, Jolita; van Roermund, Carlo W. T.; Bosma, Marjolein; Gerrits, Johan; Houten, Sander M.; Ijlst, Lodewijk; Waterham, Hans R.; Karnebeek, Clara D. M. van; Wanders, Ronald J. A.; Zwartkruis, Fried J. T.; Jans, Judith J.; Verhoeven-Duif, Nanda M. 分享 收藏
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Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1 Mataki, Chikage; Magnier, Benjamin C.; Houten, Sander M.; Annicotte, Jean-Sebastien; Argmann, Carmen; Thomas, Charles; Overmars, Henk; Kulik, Wirn; Metzger, Daniel; Auwerx, Johan; Schoonjans, Kristina 分享 收藏
Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency Webb, Bryn D.; Nowinski, Sara M.; Solmonson, Ashley; Ganesh, Jaya; Rodenburg, Richard J.; Leandro, Joao; Evans, Anthony; Vu, Hieu S.; Naidich, Thomas P.; Gelb, Bruce D.; DeBerardinis, Ralph J.; Rutter, Jared; Houten, Sander M. 分享 收藏
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients Peters, Lauren A.; Friedman, Joshua R.; Stojmirovic, Aleksandar; Hagen, Jacob; Houten, Sander; Dodatko, Tetyana; Amaro, Mariana P.; Restrepo, Paula; Chai, Zhi; Rodrigo Mora, J.; Raymond, Holly A.; Curran, Mark; Dobrin, Radu; Das, Anuk; Xiong, Huabao; Schadt, Eric E.; Argmann, Carmen; Losic, Bojan 分享 收藏
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes Wickramasinghe, Nadeera M.; Sachs, David; Shewale, Bhavana; Gonzalez, David M.; Dhanan-Krishnan, Priyanka; Torre, Denis; LaMarca, Elizabeth; Raimo, Serena; Dariolli, Rafael; Serasinghe, Madhavika N.; Mayourian, Joshua; Sebra, Robert; Beaumont, Kristin; Iyengar, Srinivas; French, Deborah L.; Hansen, Arne; Eschenhagen, Thomas; Chipuk, Jerry E.; Sobie, Eric A.; Jacobs, Adam; Akbarian, Schahram; Ischiropoulos, Harry; Ma'ayan, Avi; Houten, Sander M.; Costa, Kevin; Dubois, Nicole C. 分享 收藏
Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets Di'Narzo, Antonio F.; Houten, Sander M.; Kosoy, Roman; Huang, Ruiqi; Vaz, Frederic M.; Hou, Ruixue; Wei, Gabrielle; Wang, Wenhui; Comella, Phillip H.; Dodatko, Tetyana; Rogatsky, Eduard; Stojmirovic, Aleksandar; Brodmerkel, Carrie; Perrigoue, Jacqueline; Hart, Amy; Curran, Mark; Friedman, Joshua R.; Zhu, Jun; Agrawal, Manasi; Cho, Judy; Ungaro, Ryan; Dubinsky, Marla C.; Sands, Bruce E.; Suarez-Farinas, Mayte; Schadt, Eric E.; Colombel, Jean-Frederic; Kasarskis, Andrew; Hao, Ke; Argmann, Carmen 分享 收藏
A mechanistic framework for cardiometabolic and coronary artery diseases Koplev, Simon; Seldin, Marcus; Sukhavasi, Katyayani; Ermel, Raili; Pang, Shichao; Zeng, Lingyao; Bankier, Sean; Di Narzo, Antonio; Cheng, Haoxiang; Meda, Vamsidhar; Ma, Angela; Talukdar, Husain; Cohain, Ariella; Amadori, Letizia; Argmann, Carmen; Houten, Sander M.; Franzen, Oscar; Mocci, Giuseppe; Meelu, Omar A.; Ishikawa, Kiyotake; Whatling, Carl; Jain, Anamika; Jain, Rajeev Kumar; Gan, Li-Ming; Giannarelli, Chiara; Roussos, Panos; Hao, Ke; Schunkert, Heribert; Michoel, Tom; Ruusalepp, Arno; Schadt, Eric E.; Kovacic, Jason C.; Lusis, Aldon J.; Bjorkegren, Johan L. M. 分享 收藏
Leveraging health systems data to characterize a large effect variant conferring risk for liver disease in Puerto Ricans 利用卫生系统数据来表征赋予波多黎各人肝病风险的大效应变异 Belbin, Gillian M.; Rutledge, Stephanie; Dodatko, Tetyana; Cullina, Sinead; Turchin, Michael C.; Kohli, Sumita; Torre, Denis; Yee, Muh-Ching; Gignoux, Christopher R.; Abul-Husn, Noura S.; Houten, Sander M.; Kenny, Eimear E. 分享 收藏
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Murine deficiency of peroxisomal l-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis Ranea-Robles, Pablo; Violante, Sara; Argmann, Carmen; Dodatko, Tetyana; Bhattacharya, Dipankar; Chen, Hongjie; Yu, Chunli; Friedman, Scott L.; Puchowicz, Michelle; Houten, Sander M. 分享 收藏
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