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J

John C. Chaput

University of California

40H指数
187论文数
6.8K被引数
收录论文 89
发表时间
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Dynamism and evolvability in nucleic acid enzymes核酸酶的动态性与可进化性
errNature Communications
IF15.7
err2026-08-14
err0
errOAAI
errErica M. Lee; John C. Chaput
err分享
err收藏
How custom polymerases are driving innovation in synthetic biology定制聚合酶如何推动合成生物学创新
errCurrent Opinion in Chemical Biology
IF6.1
err2026-04-15
err0
PREAI
errMohammad Hajjar; Alex R. Horton; Victoria A. Maola; Nicholas Chim; John C. Chaput
err分享
err收藏
Xeno-nucleic acids support formation of Ag(I)-mediated duplexes and silver nanoclusters外源核酸支持Ag(I)介导的双链体和银纳米簇的形成
errNucleic Acids Research
IF13.1
err2026-02-27
err0
PREAI
errGuha, Rweetuparna; Bethur, Eshana; Chim, Nicholas; Gupta, Manoj K.; Lin, I-Hsin; Taylor, Rebecca E.; Chaput, John C.; Copp, Stacy M.
err分享
err收藏
Allele-specific knockdown by an engineered DNAzyme capable of RNase H1 evasionLee, E.M.; Nguyen, K.; Setterholm, N.A.; Malik, T.N.; Chaput, J.C. 一种能够规避RNase H1的工程化Dnazyme实现的等位基因特异性敲低。Nucleic Acids Res. 2026, 54, gkaf1476. [Google Scholar] [CrossRef]
errNucleic Acids Research
IF13.1
err2026-01-13
err1
PREAI
errLee, Erica M.; Nguyen, Kim; Setterholm, Noah A.; Malik, Turnee N.; Chaput, John C.
err分享
err收藏
Rapid evolution of a highly efficient RNA polymerase by homologous recombination通过同源重组实现高效RNA聚合酶的快速进化
errNature Chemical Biology
IF13.7
err2026-01-07
err0
PREAI
errEsau L. Medina; Victoria A. Maola; Mohammad Hajjar; Grace K. Ko; Ethan J. Ho; Alexandria R. Horton; Nicholas Chim; John C. Chaput
err分享
err收藏
Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysisTNA聚合酶的定向进化确定了通向保真度和催化作用的独立路径
errNature Communications
IF15.7
err2025-12-19
err0
errOAAI
errMohammad Hajjar; Victoria A. Maola; Joy J. Lee; Manuel J. Holguin; Riley N. Quijano; Kalvin K. Nguyen; Katherine L. Ho; Jenny V. Medina; Elionel Botello-Cornejo; Bhawna Barpuzary; Nicholas Chim; John C. Chaput
err分享
err收藏
Synthesis and Biophysical Properties of 3′-Deoxy-β-d-apio-d-furanosyl Nucleic Acids3′-脱氧-β-d-苹果糖基核酸的合成与生物物理性质
errACS Chemical Biology
IF3.8
err2025-10-23
err0
PREAI
errVictorio Jauregui-Matos; Dhrubajyoti Datta; Jayanta Kundu; Vathan Kumar; Joel M. Harp; Adekunle Adebayo; Daniel Donnelly; Esau Medina; John C. Chaput; Martin Egli; Muthiah Manoharan
err分享
err收藏
Scalable Multistep One-Pot Synthesis of Natural and Modified Nucleoside Triphosphates
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2025-04-01
err0
PREAI
errNegria, Sergei; Jia, Yinglong; Setterholm, Noah A.; Barpuzary, Bhawna; Chaput, John C.
err分享
err收藏
Measuring XNA polymerase fidelity in a hydrogel particle format在胶束颗粒体系中测定XNA聚合酶的保真度
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-01-29
err0
errOAAI
errMedina, Esau L.; Chaput, John C.
err分享
err收藏
Revealr-Based Diagnostic Panel for Rapid Detection of Acute Respiratory Infections
errACS SYNTHETIC BIOLOGY
IF3.9
err2024-12-04
err0
PREAI
errSchuder, Daniel N.; Lu, Nhi D.; Chaput, John C.
err分享
err收藏
Increasing the functional density of threose nucleic acid
errRSC CHEMICAL BIOLOGY
IF3.1
err2024-01-01
err5
errOAAI
errMajumdar, Biju; Sarma, Daisy; Yu, Yutong; Lozoya-Colinas, Adriana; Chaput, John C.
err分享
err收藏
Functionally Enhanced XNA Aptamers Discovered by Parallelized Library Screening
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-11-14
err7
errOAAI
errLozoya-Colinas, Adriana; Yu, Yutong; Chaput, John C.
err分享
err收藏
Stability and mechanism of threose nucleic acid toward acid-mediated degradation
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-08-31
err12
errOAAI
errLee, Erica M.; Setterholm, Noah A.; Hajjar, Mohammad; Barpuzary, Bhawna; Chaput, John C.
err分享
err收藏
Shorter Is Better: The a-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-08-28
err12
PREAI
errMatsuda, Shigeo; Bala, Saikat; Liao, Jen-Yu; Datta, Dhrubajyoti; Mikami, Atsushi; Woods, Lauren; Harp, Joel M.; Gilbert, Jason A.; Bisbe, Anna; Manoharan, Rajar M.; Kim, MaryBeth; Theile, Christopher S.; Guenther, Dale C.; Jiang, Yongfeng; Agarwal, Saket; Maganti, Rajanikanth; Schlegel, Mark K.; Zlatev, Ivan; Charisse, Klaus; Rajeev, Kallanthottathil G.; Castoreno, Adam; Egli, Martin; Janas, Maja M.; Egli, Martin; Chaput, John C.; Manoharan, Muthiah
err分享
err收藏
Highly Parallelized Screening of Functionally Enhanced XNA Aptamers in Uniform Hydrogel Particles
errACS SYNTHETIC BIOLOGY
IF3.9
err2023-07-06
err11
PREAI
errYik, E. J.; Medina, E.; Paegel, B. M.; Chaput, John C.
err分享
err收藏
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity
errNATURE COMMUNICATIONS
IF15.7
err2023-04-27
err19
errOAAI
errNguyen, Kim; Malik, Turnee N.; Chaput, John C.
err分享
err收藏
Amplification-Free COVID-19 Detection by Digital Droplet REVEALR
errACS SYNTHETIC BIOLOGY
IF3.9
err2023-03-22
err5
errOAAI
errYang, Kefan; Chaput, John C.
err分享
err收藏
Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-09-17
err4
errOAAI
errHajjar, Mohammad; Chim, Nicholas; Liu, Chao; Herdewijn, Piet; Chaput, John C.
err分享
err收藏
Reply to: On gene silencing by the X10-23 DNAzyme
errNATURE CHEMISTRY
IF20.2
err2022-07-18
err3
PREAI
errSpitale, Robert C.; Chaput, John C.
err分享
err收藏
REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-06-21
err18
errOAAI
errYang, Kefan; Schuder, Daniel N.; Ngor, Arlene K.; Chaput, John C.
err分享
err收藏

研究方向

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