David J. Brockwell - Publications, H-index & Citations

David J. Brockwell

university of leeds

43H指数

155论文数

5.7K被引数

收录论文 74

发表时间

In silico peptide self-assembly reveals the importance of N-terminal motifs and the inhibition mechanism of the mutation L38M in α-synuclein fibrillation 基于计算机的肽自组装揭示了N端基序的重要性以及突变L38M对α-突触核蛋白纤维化的抑制机制

Protein Science

IF5.2

2026-03-12

OAAI

Van T. T. Nguyen; Sabine M. Ulamec; David J. Brockwell; Sheena E. Radford; Carol K. Hall

Mapping the Role of Monomer Conformation in the Amyloid Formation of α-Synuclein Splice Variants 绘制α-突触核蛋白剪接变体在淀粉样蛋白形成中单体构象的作用

Journal of the American Chemical Society

IF15.6

2025-10-24

OAAI

Katherine M. Dewison; Alexander I. P. Taylor; David J. Brockwell; Sheena E. Radford

Structural and thermodynamic classification of amyloid polymorphs 淀粉样蛋白多晶型的结构和热力学分类

Structure

IF4.3

2025-07-28

OAAI

Jack P. Connor; Sheena E. Radford; David J. Brockwell

In the flow, how fluid dynamics shapes amyloid formation 在流动中，流体动力学如何塑造淀粉样蛋白形成

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-04-15

OAAI

Willis, Leon F.; Brockwell, David J.

Nanomachine Networks: Functional All-Enzyme Hydrogels from Photochemical Cross-Linking of Glucose Oxidase

BIOMACROMOLECULES

IF5.4

2025-01-23

OAAI

Laurent, Harrison; Brockwell, David J.; Dougan, Lorna

Capturing the impact of protein unfolding on the dynamic assembly of protein networks 捕获蛋白质展开对蛋白质网络动态组装的影响

SOFT MATTER

IF2.8

2025-01-01

OAAI

Hughes, Matt D. G.; Cussons, Sophie; Borumand, Ahmad; Tyler, Arwen I. I.; Brockwell, David J.; Dougan, Lorna

Competition between cross-linking and force-induced local conformational changes determines the structure and mechanics of labile protein networks

JOURNAL OF COLLOID AND INTERFACE SCIENCE

IF9.7

2025-01-01

OAAI

Hughes, Matt D. G.; West, Daniel; Wurr, Rebecca; Cussons, Sophie; Cook, Kalila R.; Mahmoudi, Najet; Head, David; Brockwell, David J.; Dougan, Lorna

Capturing Dynamic Assembly of Nanoscale Proteins During Network Formation 在网络形成过程中捕获纳米级蛋白质的动态组装

SMALL

IF12.1

2024-11-12

OAAI

Hughes, Matt D. G.; Cook, Kalila R.; Cussons, Sophie; Boroumand, Ahmad; Tyler, Arwen I. I.; Head, David; Brockwell, David J.; Dougan, Lorna

Dual client binding sites in the ATP-independent chaperone SurA

NATURE COMMUNICATIONS

IF15.7

2024-09-14

OAAI

Schiffrin, Bob; Crossley, Joel A.; Walko, Martin; Machin, Jonathan M.; Khan, G. Nasir; Manfield, Iain W.; Wilson, Andrew J.; Brockwell, David J.; Fessl, Tomas; Calabrese, Antonio N.; Radford, Sheena E.; Zhuravleva, Anastasia

Residues 2 to 7 of α- synuclein regulate amyloid formation via lipid- dependent and lipid- independent pathways Α-突触核蛋白的残基2至7通过脂质依赖性和非脂质依赖性途径调节淀粉样蛋白的形成

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-08-12

OAAI

Dewison, Katherine M.; Rowlinson, Benjamin; Machin, Jonathan M.; Crossley, Joel A.; Thacker, Dev; Wilkinson, Martin; Ulamec, Sabine M.; Khan, G. Nasir; Ranson, Neil A.; van Oosten-Hawle, Patricija; Brockwell, David J.; Radford, Sheena E.

Exploring a Role for Flow-Induced Aggregation Assays in Platform Formulation Optimisation for Antibody-Based Proteins 探索流动诱导的聚集测定在基于抗体的蛋白质的平台配方优化中的作用

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2024-03-01

OAAI

Willis, Leon F.; Toprani, Vishal; Wijetunge, Sashini; Sievers, Annette; Lin, Laura; Williams, Jeanine; Crowley, Tom J.; Radford, Sheena E.; Kapur, Nikil; Brockwell, David J.

Substitution of Met-38 to Ile in γ- synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-01-03

OAAI

Aubrey, Liam D.; Ninkina, Natalia; Ulamec, Sabine M.; Abramycheva, Natalia Y.; Vasili, Eftychia; Devine, Oliver M.; Wilkinson, Martin; Mackinnon, Eilish; Limorenko, Galina; Walko, Martin; Muwanga, Sarah; Amadio, Leonardo; Peters, Owen M.; Illarioshkin, Sergey N.; Outeiro, Tiago F.; Ranson, Neil A.; Brockwell, David J.; Buchman, Vladimir L.; Radford, Sheena E.

Visualization of Self-Assembly and Hydration of a β-Hairpin through Integrated Small and Wide-Angle Neutron Scattering

BIOMACROMOLECULES

IF5.4

2023-10-24

OAAI

Laurent, Harrison; Hughes, Matt D. G.; Walko, Martin; Brockwell, David J.; Mahmoudi, Najet; Youngs, Tristan G. A.; Headen, Thomas F.; Dougan, Lorna

Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks

NATURE COMMUNICATIONS

IF15.7

2023-09-11

OAAI

Hughes, Matt D. G.; Cussons, Sophie; Hanson, Benjamin S.; Cook, Kalila R.; Feller, Timea; Mahmoudi, Najet; Baker, Daniel L.; Ariens, Robert; Head, David A.; Brockwell, David J.; Dougan, Lorna

Structural and mechanical properties of folded protein hydrogels with embedded microbubbles

BIOMATERIALS SCIENCE

IF5.7

2023-01-01

OAAI

Brown, Christa P.; Hughes, Matt D. G.; Mahmoudi, Najet; Brockwell, David J.; Coletta, P. Louise; Peyman, Sally; Evans, Stephen D.; Dougan, Lorna

Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

NATURE COMMUNICATIONS

IF15.7

2022-08-25

OAAI

Ulamec, Sabine M.; Maya-Martinez, Roberto; Byrd, Emily J.; Dewison, Katherine M.; Xu, Yong; Willis, Leon F.; Sobott, Frank; Heath, George R.; Hawle, Patricija van Oosten; Buchman, Vladimir L.; Radford, Sheena E.; Brockwell, David J.

Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation

ACS NANO

IF16

2022-06-22

OAAI

Hughes, Matt D. G.; Cussons, Sophie; Mahmoudi, Najet; Brockwell, David J.; Dougan, Lorna

Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding

COMMUNICATIONS BIOLOGY

IF5.1

2022-06-08

OAAI

Schiffrin, Bob; Machin, Jonathan M.; Karamanos, Theodoros K.; Zhuravleva, Anastasia; Brockwell, David J.; Radford, Sheena E.; Calabrese, Antonio N.