Hiroshi Nagase - Publications, H-index & Citations

Hiroshi Nagase

University of Tsukuba

50H指数

541论文数

1.1W被引数

收录论文 106

发表时间

Rapid-Onset Therapeutic Effects of Delta Opioid Receptor Agonists on Depression-Like Behaviors Induced by Chronic Social Defeat Stress δ阿片受体激动剂对慢性社交挫败应激诱导的抑郁样行为的快速起效治疗作用

NEUROPSYCHOPHARMACOLOGY REPORTS

IF1.5

2025-12-01

OAAI

Tokuda, Akihisa; Nagumo, Yasuyuki; Kajino, Keita; Iio, Keita; Sakurai, Katsuyasu; Mizuno, Seiya; Saitoh, Akiyoshi; Saitoh, Tsuyoshi; Nagase, Hiroshi

Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor 人类κ阿片受体偏倚信号机制的结构与动态研究

Nature Communications

IF15.7

2025-10-28

OAAI

Chiyo Suno-Ikeda; Ryo Nishikawa; Riko Suzuki; Shun Yokoi; Seiya Iwata; Tomoyo Takai; Takaya Ogura; Mika Hirose; Akihisa Tokuda; Risako Katamoto; Akitoshi Inoue; Eri Asai; Ryoji Kise; Yukihiko Sugita; Takayuki Kato; Hiroshi Nagase; Ayori Mitsutake; Tsuyoshi Saitoh; Kota Katayama; Asuka Inoue; Hideki Kandori; Takuya Kobayashi; Ryoji Suno

SEX DIFFERENCES IN THE REDUCTION OF HOPELESSNESS IN M OPIOID RECEPTOR DEFICIENT MICE BY ADDITIVE EFFECTS OF Δ OPIOID RECEPTOR AGONISTS 绝望感的减少在M阿片受体缺陷小鼠中通过δ阿片受体激动剂的附加效应所表现的性别差异

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

IF3.7

2025-02-12

OAAI

Moriya, Yuki; Kasahara, Yoshiyuki; Shimada, Masafumi; Sakakibara, Yasufumi; Fujii, Hideaki; Nagase, Hiroshi; Ide, Soichiro; Ikeda, Kazutaka; Hall, Frank Scott; Uhl, George R.; Sora, Ichiro

Stimulation of kappa opioid receptors in the nucleus accumbens promotes feeding behavior in mice: Acute restoration of feeding during anorexia induced by 5-fluorouracil

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2024-12-01

PREAI

Yonemochi, Naomi; Nagase, Hiroshi; Waddington, John L.; Ikeda, Hiroko

Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors

NATURE COMMUNICATIONS

IF15.7

2024-04-30

OAAI

Roy, Koustav; Zhou, Xuzhao; Otani, Rintaro; Yuan, Ping-Chuan; Ioka, Shuji; Vogt, Kaspar E.; Kondo, Tamae; Farag, Nouran H. T.; Ijiri, Haruto; Wu, Zhaofa; Chitose, Youhei; Amezawa, Mao; Uygun, David S.; Cherasse, Yoan; Nagase, Hiroshi; Li, Yulong; Yanagisawa, Masashi; Abe, Manabu; Basheer, Radhika; Wang, Yi-Qun; Saitoh, Tsuyoshi; Lazarus, Michael

Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton

ORGANIC LETTERS

IF5

2023-05-08

PREAI

Maeda, Kenta; Ohrui, Sayaka; Tokuda, Akihisa; Nagumo, Yasuyuki; Yamamoto, Naoshi; Tanimura, Ryuji; Saitoh, Tsuyoshi; Kutsumura, Noriki; Nagase, Hiroshi

Design and Synthesis of Orexin 1 Receptor-Selective Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-04-12

OAAI

Iio, Keita; Hashimoto, Kao; Nagumo, Yasuyuki; Amezawa, Mao; Hasegawa, Taisei; Yamamoto, Naoshi; Kutsumura, Noriki; Takeuchi, Katsuhiko; Ishikawa, Yukiko; Yamamoto, Hikari; Tokuda, Akihisa; Sato, Tetsu; Uchida, Yasuo; Inoue, Asuka; Tanimura, Ryuji; Yanagisawa, Masashi; Nagase, Hiroshi; Saitoh, Tsuyoshi

Role for μ-opioid receptor in antidepressant effects of 8-opioid receptor agonist KNT-127

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2023-03-01

OAAI

Moriya, Yuki; Kasahara, Yoshiyuki; Shimada, Masafumi; Sakakibara, Yasufumi; Fujii, Hideaki; Nagase, Hiroshi; Ide, Soichiro; Ikeda, Kazutaka; Hall, F. Scott; Uhl, George R.; Sora, Ichiro

Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and Κ opioid receptors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-01-01

OAAI

Uenohara, Yuka; Tsumura, Saori; Hirayama, Shigeto; Higashi, Eika; Watanabe, Yurie; Gouda, Hiroaki; Nagase, Hiroshi; Fujii, Hideaki

Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-09-22

OAAI

Nagata, Kazuki; Nagase, Hiroshi; Okuzumi, Ayumi; Nishiyama, Chiharu

Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors

CELL REPORTS

IF6.9

2021-08-01

OAAI

Tsai, Chia-Jung; Nagata, Takeshi; Liu, Chih-Yao; Suganuma, Takaya; Kanda, Takeshi; Miyazaki, Takehiro; Liu, Kai; Saitoh, Tsuyoshi; Nagase, Hiroshi; Lazarus, Michael; Vogt, Kaspar E.; Yanagisawa, Masashi; Hayashi, Yu

Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation

SCIENTIFIC REPORTS

IF3.9

2021-04-21

OAAI

Shokirova, Hurramhon; Inomata, Takenori; Saitoh, Tsuyoshi; Zhu, Jun; Fujio, Kenta; Okumura, Yuichi; Yanagawa, Ai; Fujimoto, Keiichi; Sung, Jaemyoung; Eguchi, Atsuko; Miura, Maria; Nagino, Ken; Hirosawa, Kunihiko; Kuwahara, Mizu; Akasaki, Yasutsugu; Nagase, Hiroshi; Murakami, Akira

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

MOLECULES

IF4.6

2020-03-02

OAAI

Kutsumura, Noriki; Koyama, Yasuaki; Saitoh, Tsuyoshi; Yamamoto, Naoshi; Nagumo, Yasuyuki; Miyata, Yoshiyuki; Hokari, Rei; Ishiyama, Aki; Iwatsuki, Masato; Otoguro, Kazuhiko; Omura, Satoshi; Nagase, Hiroshi

Research and development of κ opioid receptor agonists and δ opioid receptor agonists

PHARMACOLOGY & THERAPEUTICS

IF12.5

2020-01-01

OAAI

Nagase, Hiroshi; Saitoh, Akiyoshi

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-04-01

PREAI

Yamamoto, Naoshi; Ohrui, Sayaka; Okada, Takahiro; Saitoh, Tsuyoshi; Kutsumura, Noriki; Nagumo, Yasuyuki; Irukayama-Tomobe, Yoko; Ogawa, Yasuhiro; Ishikawa, Yukiko; Watanabe, Yurie; Hayakawa, Daichi; Gouda, Hiroaki; Yanagisawa, Masashi; Nagase, Hiroshi

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2019-03-01

OAAI

Sugiyama, Azusa; Yamada, Misa; Furuie, Hiroki; Gotoh, Leo; Saitoh, Akiyoshi; Nagase, Hiroshi; Oka, Jun-Ichiro; Yamada, Mitsuhiko

Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions

CHEMELECTROCHEM

IF3.5

2018-11-30

OAAI

Zhang, Yan; Sugai, Tomoya; Yamamoto, Takashi; Yamamoto, Naoshi; Kutsumura, Noriki; Einaga, Yasuaki; Nishiyama, Shigeru; Saitoh, Tsuyoshi; Nagase, Hiroshi

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice

JOURNAL OF PHARMACOLOGICAL SCIENCES

IF2.9

2018-11-01

OAAI

Saitoh, Akiyoshi; Soda, Akinobu; Kayashima, Shuhei; Yoshizawa, Kazumi; Oka, Jun-Ichiro; Nagase, Hiroshi; Yamada, Mitsuhiko

Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats

PSYCHOPHARMACOLOGY

IF3.3

2018-07-31

PREAI

Sugiyama, Azusa; Yamada, Misa; Saitoh, Akiyoshi; Nagase, Hiroshi; Oka, Jun-Ichiro; Yamada, Mitsuhiko