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N

N.C.J. Strynadka

University of British Columbia

79H指数
465论文数
2.0W被引数
收录论文 139
发表时间
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Stk1 is required for BlaR1-mediated broad-spectrum β-lactam resistance in epidemic-causing strains of Staphylococcus aureusStk1对于金黄色葡萄球菌流行致病菌株中BlaR1介导的广谱β-内酰胺类抗生素耐药性是必需的
errNature Communications
IF15.7
err2026-09-16
err0
errOAAI
errRaymond Poon; Nidhi Satishkumar; Wesley A. Mosimann; Vedangi D. Hayatnagarkar; Swagata Bose; Vijay Hemmadi; Skyler Kuhn; Aditi Chatterjee; Liam Worrall; Nathan P. Manes; J. Andrew N. Alexander; Justin Lack; Henry F. Chambers; Aleksandra Nita-Lazar; Natalie C. J. Strynadka; Som S. Chatterjee
err分享
err收藏
Drugging the intrinsically disordered transactivation domain of androgen receptor雄激素受体内在紊乱的反式激活结构域的药物治疗
errSignal Transduction and Targeted Therapy
IF52.7
err2026-04-28
err0
errOAAI
errJon K. Obst; Carmen A. Banuelos; Kunzhong Jian; Amy H. Tien; Oleksandr A. Shkrabak; Jun Wang; Nasrin R. Mawji; Teresa Tam; Marija Vuckovic; David E. Williams; Jason C. Rogalski; Xiaojing Yuan; Natalie C. J. Strynadka; Raymond J. Andersen; Marianne D. Sadar
err分享
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Functional Analysis of the Halastavi árva Virus (HalV) Internal Ribosome Entry Site哈尔斯塔维·阿尔瓦病毒（HalV）内部核糖体进入位点的功能分析
errViruses
IF3.5
err2026-04-23
err0
errOAAI
errSubash Chapagain; Lauren F. Woodburn; Natalie C. J. Strynadka; Eric Jan
err分享
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Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs金黄色葡萄球菌酚溶性调制素外排蛋白PmtCD apo形式在去垢剂胶束、纳米盘和肽盘中的冷冻电镜分析
errCommunications Biology
IF5.1
err2025-11-17
err0
errOAAI
errJinhong Hu; Aleksander C. Lazarski; Franco K. K. Li; Liam J. Worrall; Dylan J. Burgin; Natalie Zeytuni; Seth W. Dickey; Michael Otto; Natalie C. J. Strynadka
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Structure of a SLC26 Anion Transporter STAS Domain in Complex with Acyl Carrier Protein: Implications for E. coli YchM in Fatty Acid MetabolismSLC26阴离子转运蛋白STAS结构域与酰基载体蛋白复合物的结构：对大肠杆菌YchM在脂肪酸代谢中作用的启示
errStructure
IF4.3
err2025-11-04
err0
PREAI
errMohan Babu; Jack F. Greenblatt; Andrew Emili; Natalie C.J. Strynadka; Reinhart A.F. Reithmeier; Trevor F. Moraes
err分享
err收藏
Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices形成离散的β-桶状稳定孔洞，并由跨膜螺旋锚定的抗菌肽类
errNature Communications
IF15.7
err2025-08-06
err0
errOAAI
errSeth W. Dickey; Dylan J. Burgin; Ama N. Antwi; Amer Villaruz; Madeline R. Galac; Gordon Y. C. Cheung; Tatiana K. Rostovtseva; Liam J. Worrall; Aleksander C. Lazarski; Elio A. Cino; D. Peter Tieleman; Sergey M. Bezrukov; Natalie C. J. Strynadka; Michael Otto
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Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance治疗性Nirmatrelvir耐药突变在主要蛋白酶（Mpro）低频下的功能与结构表征揭示了一种SARS-CoV-2获得耐药性的独特进化路径
errJOURNAL OF INFECTIOUS DISEASES
IF4.5
err2025-06-01
err0
errOAAI
errDeschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A.
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Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH冷冻电镜分析揭示了S. aureus WTA转运蛋白TarGH的机制细节及targocil-II介导的抑制作用。
errNATURE COMMUNICATIONS
IF15.7
err2025-04-04
err0
errOAAI
errLi, Franco K. K.; Peters, Shaun C.; Worrall, Liam J.; Sun, Tianjun; Hu, Jinhong; Vuckovic, Marija; Farha, Maya; Palacios, Armando; Caveney, Nathanael A.; Brown, Eric D.; Strynadka, Natalie C. J.
err分享
err收藏
Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2)
errBREAST CANCER RESEARCH
IF5.6
err2024-11-26
err0
errOAAI
errFoo, Jane; Gentile, Francesco; Massah, Shabnam; Morin, Helene; Singh, Kriti; Lee, Joseph; Smith, Jason; Ban, Fuqiang; Leblanc, Eric; Young, Robert; Strynadka, Natalie; Lallous, Nada; Cherkasov, Artem
err分享
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Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance
errNATURE COMMUNICATIONS
IF15.7
err2024-11-16
err0
errOAAI
errSverak, Helena E.; Yaeger, Luke N.; Worrall, Liam J.; Vacariu, Condurache M.; Glenwright, Amy J.; Vuckovic, Marija; Al Azawi, Zayni-Dean; Lamers, Ryan P.; Marko, Victoria A.; Skorupski, Clarissa; Soni, Arvind S.; Tanner, Martin E.; Burrows, Lori L.; Strynadka, Natalie C. J.
err分享
err收藏
Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens
errACS CATALYSIS
IF13.1
err2024-08-26
err0
PREAI
errTian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A.; Rahfeld, Peter; Mu, Wanmeng; Kizhakkedathu, Jayachandran N.; Strynadka, Natalie C. J.; Withers, Stephen G.
err分享
err收藏
Kinetic comparison of all eleven viral polyprotein cleavage site processing events by SARS-CoV-2 main protease using a linked protein FRET platform
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-06-01
err2
errOAAI
errKenward, Calem; Vuckovic, Marija; Paetzel, Mark; Strynadka, Natalie C. J.
err分享
err收藏
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1单功能金黄色葡萄球菌PBP1的结构和动力学分析
errJOURNAL OF STRUCTURAL BIOLOGY
IF5.1
err2024-06-01
err2
errOAAI
errBon, Christopher G.; Grigg, Jason C.; Lee, Jaeyong; Robb, Craig S.; Caveney, Nathanael A.; Eltis, Lindsay D.; Strynadka, Natalie C. J.
err分享
err收藏
Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance
errSCIENCE ADVANCES
IF12.5
err2024-03-01
err0
errOAAI
errLi, Franco K. K.; Worrall, Liam J.; Gale, Robert T.; Brown, Eric D.; Strynadka, Natalie C. J.
err分享
err收藏
Structural Insights into Type III Secretion Systems of the Bacterial Flagellum and Injectisome
errANNUAL REVIEW OF MICROBIOLOGY
IF9.9
err2023-09-15
err14
errOAAI
errWorrall, Liam J.; Majewski, Dorothy D.; Strynadka, Natalie C. J.
err分享
err收藏
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-09-15
err1
errOAAI
errYu, Hong; Worrall, Liam J.; Berger, Thorsten; Petric, Martin; Lin, Bryan H.; Vuckovic, Marija; Robb, Craig S.; Le, Quan; Kenward, Calem; Dai, Chuanbin; Wakeham, Andrew; Liu, Shaofeng; Snow, Bryan; Tobin, Chantal; Budylowski, Patrick; Guvenc, Furkan; You-Ten, Annick; Haight, Jillian; Silvester, Jennifer; Singh, Rashim Pal; Ahn, Sang Kyun; Sultana, Azmiri; Poon, Betty; Lam, Jessica; Christie-Holmes, Natasha; Ostrowski, Mario; Gray-Owen, Scott D.; Kubli, Shawn; Mak, Tak; Strynadka, Natalie C. J.; Brunham, Robert C.
err分享
err收藏
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants
errEMERGING MICROBES & INFECTIONS
IF7.5
err2023-08-23
err2
errOAAI
errPerez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois
err分享
err收藏
Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-05-26
err1
errOAAI
errMalwal, Satish R. R.; Mazurek, Ben; Ko, Jihee; Xie, Pujun; Barnes, Chikako; Varvitsiotis, Christine; Zimmerman, Matthew D. D.; Olatunji, Samir; Lee, Jaeyong; Xie, Min; Sarathy, Jansy; Caffrey, Martin; Strynadka, Natalie C. J.; Dartois, Veronique; Dick, Thomas; Lee, Bom Nae Rin; Russell, David G. G.; Oldfield, Eric
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Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-04-14
err2
errOAAI
errDanby, Phillip M.; Jeong, Andrew; Sim, Lyann; Sweeney, Ryan P.; Wardman, Jacob F.; Karimi, Ryan; Geissner, Andreas; Worrall, Liam J.; Reid, Jolene. P.; Strynadka, Natalie C. J.; Withers, Stephen G.
err分享
err收藏
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-03-17
err9
PREAI
errGarland, Olivia; Ton, Anh-Tien; Moradi, Shoeib; Smith, Jason R.; Kovacic, Suzana; Ng, Kurtis; Pandey, Mohit; Ban, Fuqiang; Lee, Jaeyong; Vuckovic, Marija; Worrall, Liam J.; Young, Robert N.; Pantophlet, Ralph; Strynadka, Natalie C. J.; Cherkasov, Artem
err分享
err收藏

研究方向

暂无研究方向
合作学者
合作期刊
T
Tak W. Mak
H 指数: 181 · 论文数: 1.6K
R
Robert E. W. Hancock
H 指数: 166 · 论文数: 966
B
B. Brett Finlay
H 指数: 145 · 论文数: 667
W
William R. Jacobs
H 指数: 127 · 论文数: 610
M
Michaël Otto
H 指数: 120 · 论文数: 479
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