Alex W. Hewitt - Publications, H-index & Citations

Alex W. Hewitt

Garvan Institute of Medical Research

88H指数

733论文数

3.2W被引数

收录论文 290

发表时间

The impact of sex on the immune system explored at the single-cell level 性别对免疫系统影响在单细胞水平的探索

The American Journal of Human Genetics

IF0

2026-05-07

OAAI

Seyhan Yazar; Jose Alquicira-Hernandez; Kristof Wing; Anne Senabouth; Stacey Andersen; Kirsten A. Fairfax; Alex W. Hewitt; Joseph E. Powell; Sara Ballouz

Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence 单细胞分析揭示人类免疫系统免疫衰老的性别特异性动力学

Nature Aging

IF19.4

2026-04-10

PREAI

Maria Sopena-Rios; Aida Ripoll-Cladellas; Fatemeh Omidi; Sara Ballouz; Jose Alquicira-Hernandez; Roy Oelen; Alex W. Hewitt; Lude Franke; Monique G. P. van der Wijst; Joseph E. Powell; Marta Melé

Opportunistic genomic screening of healthy controls in an Australian biobank 澳大利亚生物库中健康对照人群的机遇性基因组筛查

European Journal of Human Genetics

IF4.6

2026-04-01

OAAI

Mitchell, Lucas A.; Young, Mary-Anne; Ohnesorg, Thomas; Hobbs, Matthew; Copty, Joseph; Brown, Jaye S.; Hewitt, Alex W.; Powell, Joseph E.; Macathur, Daniel G.; Willis, Amanda M.

A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma 一项大规模的全基因组关联荟萃分析针对痣数量提供了对黑色素瘤遗传学的直接见解

Nature Communications

IF15.7

2026-03-10

OAAI

G. J. M. Shanika R. Jayasinghe; Gu Zhu; Nirmala Pandeya; Catherine M. Olsen; Nicholas G. Martin; Penelope A. Lind; Sarah E. Medland; Scott D. Gordon; Santiago Diaz-Torres; Gareth Lingham; Samantha S. Y. Lee; Tamar Nijsten; Manfred Kayser; Luba M. Pardo; Grant W. Montgomery; Nicholas K. Hayward; Jane M. Palmer; David J. Hunter; Jiali Han; Alex W. Hewitt; Mario Falchi; D. Timothy Bishop; Kevin M. Brown; Veronique Bataille; David A. Mackey; Mark M. Iles; David C. Whiteman; David L. Duffy; Stuart MacGregor; Matthew H. Law

Benchmarking Generative AI Protein Models Reveals Differences Between Structural and Sequence-based Approaches 评估生成式AI蛋白质模型揭示了基于结构和基于序列方法之间的差异

Genomics, Proteomics & Bioinformatics

IF0

2026-02-15

OAAI

Alexander J Barnett; Rajendra KC; Pratikshya Pandey; Pamodha Somasiri; Kirsten A Fairfax; Sandy Hung; Alex W Hewitt; null

CRISPR-Cas9 mediated gene therapy in inherited bone marrow failure syndromes CRISPR-Cas9介导的遗传性骨髓衰竭综合征基因治疗

Frontiers in Hematology

IF0

2025-12-03

OAAI

Munugoda Hewa, Nadeesha J. S.; Kc, Rajendra; Hewitt, Alex W.; Fairfax, Kirsten A.

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy 对散发型ALS患者来源的iPSC诱导运动神经元进行大规模药物筛选，识别出一种潜在的联合治疗方案

Nature Neuroscience

IF20

2025-11-24

OAAI

Christopher R. Bye; Elizabeth Qian; Katherine Lim; Maciej Daniszewski; Fleur C. Garton; Bảo C. Trần-Lê; Helena H. Liang; Tian Lin; John G. Lock; Duncan E. Crombie; Steven Morgan; Yi Hu; Samantha K. Barton; Lucy M. Palmer; Elvan Djouma; Saritha Kodikara; Kim-Anh Lê Cao; Thanuja Dharmadasa; Anjali K. Henders; Laura A. Ziser; Matthew C. Kiernan; Kevin Talbot; Merrilee Needham; Susan Fletcher; Paul Talman; Susan Mathers; Naomi R. Wray; Alex W. Hewitt; Alice Pebay; Bradley J. Turner

Automated quantification of Ki-67 expression in breast cancer from H&E-stained slides using a transformer-based regression model 基于Transformer回归模型的乳腺癌H&E染色切片中Ki-67表达自动定量

Breast Cancer Research

IF5.6

2025-11-19

OAAI

Abadh K. Chaurasia; Patrick W. Toohey; Matthew T. Bennett; Helen C. Harris; Alex W. Hewitt

Generalizable features of pegRNA design for prime editing of inherited retinal diseases pegRNA设计的通用特征：用于治疗遗传性视网膜疾病的碱基编辑

Ophthalmic Genetics

IF1

2025-11-01

PREAI

Patterson, Freya M.; Tran, Minh Thuan Nguyen; Guinan, Thomas; Khalid, Mohd Khairul Nizam Mohd; Kc, Rajendra; Fairfax, Kirsten A.; Liu, Guei-Sheung; Cook, Anthony L.; Hung, Sandy S.; Hewitt, Alex W.

A multitrait polygenic risk score for open-angle glaucoma stratifies risk of pigmentary glaucoma in pigment dispersion syndrome.一个多性状多基因风险评分可对色素性青光眼进行风险分层，适用于色素播散综合征患者。

Ophthalmology Glaucoma

IF3.2

2025-10-21

PREAI

Antonia Kolovos; Ayub Qassim; Henry Marshall; Thi Thi Nguyen; Joshua Schmidt; Mark M. Hassall; Victoria Tang; Giorgina Maxwell; John Landers; Richard Mills; Stewart Lake; Stuart Graham; Angela Schulz; Anna Galanopoulos; Robert J. Casson; Ivan Goldberg; Michael Coote; Stephen Best; Jed Lusthaus; Paul R. Healey; Leslie Burnett; Marc Töteberg-Harms; Erin A. Boese; Andrew E. Pouw; Puya Gharahkhani; Todd Scheetz; Alex W. Hewitt; Stuart MacGregor; Owen M. Siggs; Emmanuelle Souzeau; John H. Fingert; Jamie E. Craig

Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms 青光眼内表型的基因组结构方程模型分析：探究遗传结构和非眼内压机制

HUMAN MOLECULAR GENETICS

IF3.2

2025-10-01

PREAI

Marzban, Maryam; Diaz-Torres, Santiago; Thorp, Jackson; Ong, Jue Sheng; Khawaja, Anthony P.; Hammond, Christopher J.; Hysi, Pirro G.; Pasquale, Louis R.; Kraft, Peter; Kang, Jae H.; Hewitt, Alex W.; Mackey, David A.; Craig, Jamie E.; Wiggs, Janey L.; MacGregor, Stuart; Gharahkhani, Puya

Association of polygenic scores for glaucoma with measures of retinal ganglion cell integrity in young and older adults 青光眼多基因评分与年轻和年长成年人视网膜神经节细胞完整性指标的相关性

American Journal of Ophthalmology

IF4.2

2025-09-26

PREAI

Samantha Sze-Yee Lee; Santiago Diaz Torres; Gareth Lingham; Seyhan Yazar; Michael Hunter; Jamie E Craig; Alex W Hewitt; Stuart MacGregor; Puya Gharahkhani; David A Mackey

Multi-resolution vision transformer model for histopathological skin cancer subtype classification using whole slide images 多尺度视觉Transformer模型，用于全切片图像的皮肤癌亚型分类

Computers in Biology and Medicine

IF6.3

2025-07-09

OAAI

Abadh K. Chaurasia; Patrick W. Toohey; Helen C. Harris; Alex W. Hewitt

Evaluating Practical Approaches for Including MYOC Variants Alongside Common Variants for Genetics-Based Risk Stratification for Glaucoma 评估将MYOC变异与常见变异结合用于基于遗传学的青光眼风险分层的方法

AMERICAN JOURNAL OF OPHTHALMOLOGY

IF4.2

2025-06-01

PREAI

Le, NQ; He, WX; Law, MH; Medland, SE; Mackey, DA; Hewitt, AW; Gharahkhani, P; Macgregor, S

Reply 回复

Ophthalmology Science

IF4.6

2025-04-05

OAAI

Abadh K. Chaurasia; Connor J. Greatbatch; Xikun Han; Puya Gharahkhani; David A. Mackey; Stuart MacGregor; Jamie E. Craig; Alex W. Hewitt

Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms

EXPERIMENTAL EYE RESEARCH

IF2.7

2025-03-01

PREAI

Ratnapriya, Rinki; Grassman, Felix; Chen, Rui; Hewitt, Alex; Du, Jianhai; Saban, Daniel R.; Klaver, Caroline C. W.; Ash, John; Stambolian, Dwight; Tumminia, Santa J.; Qian, Jiang; Husain, Deeba; Iyengar, Sudha K.; den Hollander, Anneke I.

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

IF4.7

2025-03-01

OAAI

Gurung, Rajya L.; Nangia, Charvi; Cai, Tengda; Fitzgerald, Liesel M.; Mccomish, Bennet J.; Liu, Ebony; Kaidonis, Georgia; Ridge, Bronwyn; Hewitt, Alex W.; Vote, Brendan; Verma, Nitin; Craig, Jamie E.; Palmer, Colin N. A.; Burdon, Kathryn P.; Meng, Weihua

A generalised vision transformer-based self-supervised model for diagnosing and grading prostate cancer using histological images

PROSTATE CANCER AND PROSTATIC DISEASES

IF5.8

2025-03-01

OAAI

Chaurasia, Abadh K.; Harris, Helen C.; Toohey, Patrick W.; Hewitt, Alex W.

A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation 多基因风险评分在伴有伪剥脱综合征的眼中分层青光眼诊断风险和严重程度

Ophthalmology

IF9.5

2025-02-24

OAAI

Antonia Kolovos; Ayub Qassim; Mark M. Hassall; Henry N. Marshall; Joshua Schmidt; Thi Thi Nguyen; Weixiong He; Sean Mullany; Georgina L. Hollitt; Ella C. Berry; Victoria Tang; Tiger Zhou; Stewart Lake; Richard Mills; John Landers; Robert J. Casson; Anna Galanopoulos; Stuart L. Graham; Angela Schulz; Paul R. Healey; Paul Mitchell; Ivan Goldberg; John Grigg; Jonathan Ruddle; David A. Mackey; Kathryn P. Burdon; Alex W. Hewitt; Mathias Seviiri; Puya Gharahkhani; Emmanuelle Souzeau; Owen M. Siggs; Stuart MacGregor; Jamie E. Craig

Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma

NATURE COMMUNICATIONS

IF15.7

2024-11-17

OAAI

Diaz-Torres, Santiago; He, Weixiong; Yu, Regina; Khawaja, Anthony P.; Hammond, Christopher J.; Hysi, Pirro G.; Pasquale, Louis R.; Wu, Yeda; Kubo, Michiaki; Akiyama, Masato; Aung, Tin; Cheng, Ching-Yu; Khor, Chiea Chuen; Kraft, Peter; Kang, Jae H.; Hewitt, Alex W.; Mackey, David A.; Craig, Jamie E.; Wiggs, Janey L.; Ong, Jue-Sheng; MacGregor, Stuart; Gharahkhani, Puya; Han, Xikun; Hamel, Andrew R.; Young, Terri L.; Lotery, Andrew J.; Jorgenson, Eric; Choquet, Helene; Hauser, Michael; Bailey, Jessica N. Cooke; Nakazawa, Toru; Shiga, Yukihiro; Segre, Ayellet V.

研究方向