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J

Joseph R. Marszalek

the university of texas m d anderson cancer center
H指数:44
被引数:9,855

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

CDK2抑制增强了CDK4/6抑制剂在综合乳腺癌PDX模型筛选中的抗肿瘤活性

npj Breast Cancer
IF7.6
2025-12-030
OAAI
Nealia C. House; Maxine M. Chen; Sima Khazaei; Victoria Brown; Philip Ramsden; David H. Peng; Sydney Moore; Liang Yuan; Rentian Wu; Fangyang Wang; Linjie Luo; Ningping Feng; Christopher A. Bristow; Timothy A. Yap; Khandan Keyomarsi; Joseph R. Marszalek; Scott Ribich; Mikael L. Rinne; Lakshmi B. Muthuswamy; Kerrie L. Faia
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

纳武利尤单抗联合伊匹木单抗诱导肾髓质癌发生超进展：一项II期试验结果及临床前证据

Nature Communications
IF15.7
2025-11-250
OAAI
Melinda Soeung; Xinmiao Yan; Ciro Zanca; Jing Qian; Menuka Karki; Fei Duan; Hania Khan; Li Zhang; David H. Peng; Mariah Williams; Rong He; Ziheng Chen; Luigi Perelli; Jianfeng Chen; Rebecca S. Tidwell; Pankaj K. Chauhan; Courtney N. Le; Truong N. A. Lam; Nirjar Bhattacharya; Rutvi Shah; I-Lin Ho; Jason P. Gay; Caroline C. Carrillo; Ningping Feng; Kang Le; Guang Gao; Teresa L. Perry; Faika Mseeh; Yongying Jiang; Quanyun A. Xu; Niki Marie Zacharias; Rahul A. Sheth; Tharakeswara K. Bathala; Priya Rao; Najat C. Daw; Durga N. Tripathi; Cheryl L. Walker; Mohammad M. Mohammad; Jianhua Zhang; Guangchun Han; Yanshuo Chu; Ruiping Wang; Minghao Dang; Enyu Dai; Fuduan Peng; Yunhe Liu; Akshaya Jadhav; Wenhua Lang; Claudio A. Arrechedera; Leticia Campos Clemente; Edwin R. Parra; Hsinyi Lu; Cara L. Haymaker; Ignacio I. Wistuba; Andrew Futreal; Andrea Viale; Michael J. Soth; Philip Jones; Joseph R. Marszalek; Timothy Heffernan; Giulio F. Draetta; Nizar M. Tannir; Jianjun Gao; Linghua Wang; Giannicola Genovese; Pavlos Msaouel
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer
MABS
IF7.3
2024-12-090
OAAI
Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications
EUROPEAN JOURNAL OF CANCER
IF7.1
2024-10-010
PRE
Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R.
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

共靶向SOS1通过解决内在和获得性耐药增强KRASG12C抑制剂的抗肿瘤作用

NATURE CANCER
IF28.5
2024-08-051
OA
Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H.
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea
KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Peng, David Hwa; Tedeschi, Antonio; Herdeis, Lorenz; Schaaf, Otmar; Savarese, Fabio; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunberg, Tobias; Schischlik, Firoella; Lipp, Jesse; Williams, Mariah; Chandler, Vaness; Deckard, Charles E.; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, TImothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea
Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Srinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia
Development of advanced preclinical modeling for a comprehensive characterization of cardiac angiosarcoma biology
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Minelli, Rosalba; Perelli, Luigi; Bivona, Benjamin J.; Srinivasan, Sanjana; Catania, Desiree; Amador, Bianca E.; Robinson, Frederick S.; Rose, Johnathon L.; Terranova, Christopher T.; Martinez, Alejandro Hernandez; Deckard, Charles E.; Le, Courtney N.; Hsu, Kuo-Shun; Peoples, Michael; Subramaniam, Aparna; Beird, Hannah C.; Feng, Ningping; Daniele, Joseph R.; Vellano, Christopher; Marszalek, Joseph; Ravi, Vinod; Lazar, Alexander J.; Futreal, Andrew; Heffernan, Timothy P.; Genovese, Giannicola; Giuliani, Virginia
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Peng, David H.; Tedeschi, Antonio; Herdeis, Lorenz; Savarese, Fabio; Rocchetti, Francesca; Johannes, Popow; Huber, Heinrich J.; Melillo, Nicola; Dickinson, Jake; Mistry, Hitesh B.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Schischlik, Fiorella; Lipp, Jesse; Ramamoorthy, Vandhana; Daniele, Joseph R.; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea
BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Tedeschi, Antonio; Herdeis, Lorenz; Santoro, Valeria; Savarese, Fabio; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broker, Joachim; Wunberg, Tobias; Gmachl, Michael; Klaus, Rumpel; Schischlik, Fiorella; Lipp, Jesse; Peng, David H.; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Vellano, Christopher R.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea
Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Srinivasan, Sanjana; Rose, Johnathon; Daniele, Joseph R.; Peoples, Michael; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Wani, Khalida; Perelli, Luigi; Loza, Dmitriy; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Futreal, P. Andrew; Woodman, Scott E.; Lazar, Alexander J.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

晚期实体瘤和急性髓性白血病中氧化磷酸化的复合物I抑制剂: I期试验

NATURE MEDICINE
IF50
2023-01-19120
OA
Yap, Timothy A.; Daver, Naval; Mahendra, Mikhila; Zhang, Jixiang; Kamiya-Matsuoka, Carlos; Meric-Bernstam, Funda; Kantarjian, Hagop M.; Ravandi, Farhad; Collins, Meghan E.; Di Francesco, Maria Emilia; Dumbrava, Ecaterina E.; Fu, Siqing; Gao, Sisi; Gay, Jason P.; Gera, Sonal; Han, Jing; Hong, David S.; Jabbour, Elias J.; Ju, Zhenlin; Karp, Daniel D.; Lodi, Alessia; Molina, Jennifer R.; Baran, Natalia; Naing, Aung; Ohanian, Maro; Pant, Shubham; Pemmaraju, Naveen; Bose, Prithviraj; Piha-Paul, Sarina A.; Rodon, Jordi; Salguero, Carolina; Sasaki, Koji; Singh, Anand K.; Subbiah, Vivek; Tsimberidou, Apostolia M.; Xu, Quanyun A.; Yilmaz, Musa; Zhang, Qi; Li, Yuan; Bristow, Christopher A.; Bhattacharjee, Meenakshi B.; Tiziani, Stefano; Heffernan, Timothy P.; Vellano, Christopher P.; Jones, Philip; Heijnen, Cobi J.; Kavelaars, Annemieke; Marszalek, Joseph R.; Konopleva, Marina

研究方向

暂未获取到该数据
T
Timothy P. Heffernan
H 指数:52论文数:460被引数:1.8万
N
Ningping Feng
H 指数:38论文数:260被引数:5,455
G
Giulio Draetta
H 指数:83论文数:425被引数:2.9万
C
Christopher P. Vellano
H 指数:29论文数:163被引数:4,893
P
Philip Jones
H 指数:45论文数:223被引数:7,833
C
Christopher A. Bristow
H 指数:47论文数:245被引数:3.6万
M
Maria Emilia Di Francesco
H 指数:25论文数:119被引数:3,494
孙
孙玉婷
H 指数:37论文数:246被引数:6,191
J
Jason Gay
H 指数:25论文数:109被引数:3,894
M
Marina Konopleva
H 指数:130论文数:2,096被引数:7.0万