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何

何正国 (Zheng-Guo He)

wuhan university邮箱:hezhengguo2024@whu.edu.cn

H指数:18

被引数:1,129

个人简介

"教育经历 1988-1995 华中农业大学生命科学技术学院微生物专业学士、硕士学位 1998-2001 中科院微生物所微生物学专业博士学位科研与学术工作经历 2001-2004 哈佛医学院生物化学与分子药物系博士后 2004-2005 湖北大学生命科学学院教授 2005- 今华中农业大学生命科学技术学院教授、博士生导师，农业微生物学国家重点实验室PI 主讲课程微生物功能基因组学研究生招生专业微生物学"

教育背景

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工作经历

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荣誉奖项

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The peptidoglycan-binding domain regulates antimycobacterial activity of LysB by affecting its transportation and/or catalytic activity

肽聚糖结合域通过影响其运输和/或催化活性来调节LysB的抗分枝杆菌活性

Communications Biology

IF5.1

2026-06-080

OAAI

ACA kills Mycobacterium tuberculosis and M. bovis by targeting cell wall core assembling protein CpsA

ACA通过靶向细胞壁核心组装蛋白CpsA杀灭结核分枝杆菌和牛分枝杆菌。

Communications Biology

IF5.1

2025-11-260

OAAI

A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway

一种启动生物素合成的细菌甲基转移酶，一种有吸引力的抗ESKAPE药物途径

SCIENCE ADVANCES

IF12.5

2024-12-200

OAAI

Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains

NATURE COMMUNICATIONS

IF15.7

2022-08-0958

OAAI

A Novel Zinc Exporter CtpG Enhances Resistance to Zinc Toxicity and Survival in Mycobacterium bovis

MICROBIOLOGY SPECTRUM

IF3.8

2022-04-277

OAAI

Cyclic di-GMP triggers the hypoxic adaptation of Mycobacterium bovis through a metabolic switching regulator ArgR

ENVIRONMENTAL MICROBIOLOGY

IF4

2022-03-296

PRE

NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages

COMMUNICATIONS BIOLOGY

IF5.1

2019-02-1510

OAAI

Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-10-0139

OAAI

InbR, a TetR family regulator, binds with isoniazid and influences multidrug resistance in Mycobacterium bovis BCG

SCIENTIFIC REPORTS

IF3.9

2015-09-1021

OAAI

Improved understanding of pathogenesis from protein interactions in Mycobacterium tuberculosis

EXPERT REVIEW OF PROTEOMICS

IF2.8

2014-10-186

PREAI

A Genome-Wide Regulator-DNA Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv

JOURNAL OF PROTEOME RESEARCH

IF3.6

2012-08-1019

PRE

ClpR Protein-like Regulator Specifically Recognizes RecA Protein-independent Promoter Motif and Broadly Regulates Expression of DNA Damage-inducible Genes in Mycobacteria

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-09-0150

OAAI

Global Protein-Protein Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv

人类病原体结核分枝杆菌H37Rv的全局蛋白质-蛋白质相互作用网络

JOURNAL OF PROTEOME RESEARCH

IF3.6

2010-11-1081

PRE

The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis

BMC MICROBIOLOGY

IF4.2

2010-09-1673

OAAI

Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I

NUCLEIC ACIDS RESEARCH

IF13.1

2010-08-1946

OAAI

A Proteome-Scale Identification of Novel Antigenic Proteins in Mycobacterium tuberculosis toward Diagnostic and Vaccine Development

用于诊断和疫苗开发的结核分枝杆菌中新型抗原蛋白的蛋白质组规模鉴定

JOURNAL OF PROTEOME RESEARCH

IF3.6

2010-08-0647

PRE

Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis

IF3.7

2009-03-1979

OAAI

Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system

GENOME RESEARCH

IF5.5

2009-02-18125

OAAI

Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2004-05-0137

OAAI