王玉 (Yu Wang)

sun yatsen university讲

H指数:93

被引数:3.5万

个人简介

"学习经历： 2013年9月-2017年6月合肥工业大学学士 2017年9月-2023年6月中国科学技术大学博士工作经历： 2023年11月-至今合肥工业大学讲师研究方向聚焦翻译后修饰光激活蛋白工具的化学构建与在体应用，形成 “探针设计 - 高效递送 - 功能筛查” 的完整体系： 1）“光笼”蛋白探针设计与合成； 2）合成蛋白工具的活细胞递送； 3）翻译后修饰蛋白互作组的在体筛查。 1.国家自然科学基金青年项目，2025-2027，主持 2.合肥工业大学学术新人提升计划A项目，2024-2025，主持 3.合肥工业大学青年教师科研创新启动专项A项目，2024-2026，主持以第一/通讯作者（共同）在Nature Commun.、 J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、CCS Chem.、Chem. Comm. 等期刊发表研究论文10余篇。 1.Y. Wang, J. Fan, X. Meng, Q. Shu, Y. Wu, G. C. Chu*, R. Ji, Y. Ye, X. Wu, J. Shi, H. Deng, L. Liu*, Y.-M. Li*. Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells. Nat Commun. 2025, 16, 415. 2.Y. Wang, L. Liu, Q. Zheng, Y. Wu, Z. Su, R. Yuan, Q. Xia, B, Wang, Y. Yu*, Y.-M. Li*. Synergizing Structure-Guided Photocaged Linear Diubiquitin-Dha with Biotinylated Linear-Fab for Time-Resolved Profiling of Interactors in Living Cells. J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c15159. 3.Y. Wang, J. Chen, X. Hua, X. Meng, H. Cai, R. Wang, J. Shi, H. Deng, L. Liu, Y.-M. Li*. Photocaging of Activity-Based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy. Angew. Chem. Int. Ed. 2022, 61, e202203792. 4.L. Liu, P. Li, S. Yang, D. Yan, B. Wang, Y.-M. Li*, Y. Wang*. Acetylacetone-Modified Ubiquitin C-Terminus Enables Specific Capture of Sulfenylated Deubiquitinases. Chem Commun. 2026, DOI: 10.1039/D5CC05543A. 5.Q. Xia, X. Meng, Y. Wang*, R. Yuan, P. Li, L. Liu, Y.-M. Li*. A cell-permeable Ub-Dha probe for profiling E1-E2-E3 enzymes in live cells. Chem Commun. 2024, 60, 4342-4345. 6.P. Li, X. Han, B. Wang, Y. Guo, Y. Wang*, Y.-M. Li*. Efficient Synthesis of Cleavable CPP-cargo Conjugate via Low-equivalent of CPP Activated by 2,2’-dithiodipyridine. ChemBioChem. 2025, 26, e202500032. 7.L. Liu, B. Wang, S. Yang, W. Wang, Y. Wang*, Y.-M. Li*. Semi-synthesis of functionalized cell-permeable ubiquitin probes via SrtA-mediated ligation. Org. Biomol. Chem. 2025, 23, 3459. 8.D. Yang, B. Wang, Z. Song, J. Tang, N. Wang, J. Wang*, Y. Wang*, Y.-M. Li. One-step solid-phase synthesis of activated cell-penetrating peptides for cytosolic delivery of protein. Tetrahedron Lett. 2024, 153, 155385. 9.J. Chen, Y. Wang*, R. Wang, R. Yuan, G-C. Chu *, Y.-M. Li*. Chemical synthesis of on demand-activated SUMO-based probe by a photocaged glycine-assisted strategy. Bioorg. Med. Chem. Lett. 2023, 94, 129460. 10.Y. Wang, C. Chen, X. Meng, J. Fan, M. Pan, J. Chen, H. Deng, J. Shi*, L. Liu, Y.-M. Li*. Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO Chain-Specific Interacting Proteins. CCS. Chem. 2020, 2, 1157-1168. 11.Y. Wang, Q. Xia, X. Hua, Y. Guo, J. Shi*, Y.-M. Li*. Semi-synthesis of biotin-bearing activity-based ubiquitin probes through sequential enzymatic ligation, N-S acyl transfer and aminolysis reaction. Chin. Chem. Lett. 2023, 34, 108010. 12.L. J. Liang#, Y. Wang#, X. Hua#, R. Yuan, Q. Xia, R. Wang, C. Li, G. Chu, L. Liu*, Y.-M. Li*. A cell-permeable stimuli-responsive ubiquitin probe for time-resolved monitoring of substrate ubiquitination in live cells. JACS Au 2023, 3, 2873-2882. (#: equal contribution) 第一届化学生物学研究生前言论坛优秀墙报奖第二十届化学与材料科学研究生中文学术年会三等奖"