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Dynamics of spike-specific neutralizing antibodies across five-year emerging SARS-CoV-2 variants of concern reveal conserved epitopes that protect against severe COVID-19 五年新兴SARS-CoV-2变异中刺突特异性中和抗体的动态变化揭示了保护免受严重新型冠状病毒肺炎的保守表位 Zayou, Latifa; Prakash, Swayam; Vahed, Hawa; Dhanushkodi, Nisha Rajeswari; Quadiri, Afshana; Belmouden, Ahmed; Lemkhente, Zohra; Chentoufi, Aziz; Gil, Daniel; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associated with Protection Against SARS-CoV-2 Infection and COVID-19-like Symptoms in Hamsters Quadiri, Afshana; Prakash, Swayam; Zayou, Latifa; Dhanushkodi, Nisha Rajeswari; Chilukuri, Amruth; Ryan, Gemma; Wang, Kelly; Vahed, Hawa; Chentoufi, Aziz A.; Benmohamed, Lbachir 分享 收藏
Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4+ and CD8+ T cells and protects against recurrent genital herpes 用核糖核苷酸还原酶2 (RR2) 蛋白和CXCL11趋化因子对HSV-2-infected豚鼠进行治疗性初免/拉动疫苗接种可增强抗病毒局部组织驻留和效应子记忆CD4和CD8 T细胞,并预防复发性生殖器疱疹 Quadiri, Afshana; Prakash, Swayam; Dhanushkodi, Nisha Rajeswari; Singer, Mahmoud; Zayou, Latifa; Shaik, Amin Mohammed; Sun, Miyo; Suzer, Berfin; Lau, Lauren Su Lin; Chilukurri, Amruth; Vahed, Hawa; Schaefer, Hubert; Benmohamed, Lbachir 分享 收藏
High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients 在未接种疫苗的新型冠状病毒肺炎患者中,高频率的 α 普通感冒冠状病毒/SARS-CoV-2交叉反应功能性CD4和CD8记忆T细胞与保护免受症状性和致命性SARS-CoV-2感染有关 Coulon, Pierre-Gregoire; Prakash, Swayam; Dhanushkodi, Nisha R.; Srivastava, Ruchi; Zayou, Latifa; Tifrea, Delia F.; Edwards, Robert A.; Figueroa, Cesar J.; Schubl, Sebastian D.; Hsieh, Lanny; Nesburn, Anthony B.; Kuppermann, Baruch D.; Bahraoui, Elmostafa; Vahed, Hawa; Gil, Daniel; Jones, Trevor M.; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by multiple SARS-CoV-2 variants of concern 基于高度保守的人B、CD4和CD8 T细胞表位的疫苗对多种SARS-CoV-2变异引起的严重感染、疾病和死亡的交叉保护作用 Prakash, Swayam; Dhanushkodi, Nisha R.; Zayou, Latifa; Ibraim, Izabela Coimbra; Quadiri, Afshana; Coulon, Pierre Gregoire; Tifrea, Delia F.; Suzer, Berfin; Shaik, Amin Mohammed; Chilukuri, Amruth; Edwards, Robert A.; Singer, Mahmoud; Vahed, Hawa; Nesburn, Anthony B.; Kuppermann, Baruch D.; Ulmer, Jeffrey B.; Gil, Daniel; Jones, Trevor M.; BenMohamed, Lbachir 分享 收藏
Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models Rage-ig蛋白对K18-hACE2小鼠和叙利亚金黄仓鼠模型中显示的多种SARS-CoV-2变异的抗病毒和抗炎治疗作用 Dhanushkodi, Nisha Rajeswari; Prakash, Swayam; Quadiri, Afshana; Zayou, Latifa; Srivastava, Ruchi; Shaik, Amin Mohammed; Suzer, Berfin; Ibraim, Izabela Coimbra; Landucci, Gary; Tifrea, Delia F.; Singer, Mahmoud; Jamal, Leila; Edwards, Robert A.; Vahed, Hawa; Brown, Lawrence; Benmohamed, Lbachir 分享 收藏
A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection 多表位/CXCL11 prime/pull冠状病毒粘膜疫苗可提高肺部记忆性CD4和CD8 T细胞的频率和功能,并增强对SARS-CoV-2感染引起的COVID-19-like症状和死亡的保护 Zayou, Latifa; Prakash, Swayam; Dhanushkodi, Nisha Rajeswari; Quadiri, Afshana; Ibraim, Izabela Coimbra; Singer, Mahmoud; Salem, Amirah; Shaik, Amin Mohammed; Suzer, Berfin; Chilukuri, Amruth; Tran, Jennifer; Nguyen, Pauline Chau; Sun, Miyo; Hormi-Carver, Kathy K.; Belmouden, Ahmed; Vahed, Hawa; Gil, Daniel; Ulmer, Jeffrey B.; Benmohamed, Lbachir 分享 收藏
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-2CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa 粘膜CCL28趋化因子通过动员抗病毒效应记忆CCR10 CD44 CD62L-2CD8 T细胞和记忆CCR10 B220 CD27 b细胞进入感染的阴道粘膜来改善对生殖器疱疹的保护 Dhanushkodi, Nisha Rajeswari; Prakash, Swayam; Quadiri, Afshana; Zayou, Latifa; Srivastava, Ruchi; Tran, Jennifer; Dang, Vivian; Shaik, Amin Mohammed; Chilukurri, Amruth; Suzer, Berfin; De Vera, Phil; Sun, Miyo; Nguyen, Pauline; Lee, Ashley; Salem, Amirah; Loi, Joyce; Singer, Mahmoud; Nakayama, Takashi; Vahed, Hawa; Nesburn, Anthony B.; BenMohamed, Lbachir 分享 收藏
Association of Human Leucocyte Antigen Polymorphism with Coronavirus Disease 19 in Renal Transplant Recipients Prasad, Narayan; Yadav, Brijesh; Prakash, Swayam; Yadav, Deependra; Singh, Ankita; Gautam, Sonam; Bhadauria, Dharmendra; Kaul, Anupama; Patel, Manas Ranjan; Behera, Manas Ranjan; Kushwaha, Ravi Shankar; Yachha, Monika 分享 收藏
Combinatorial Herpes Simplex Vaccine Strategies: From Bedside to Bench and Back Chentoufi, Aziz A.; Dhanushkodi, Nisha R.; Srivastava, Ruchi; Prakash, Swayam; Coulon, Pierre-Gregoire A.; Zayou, Latifa; Vahed, Hawa; Chentoufi, Hiba A.; Hormi-Carver, Kathy K.; BenMohamed, Lbachir 分享 收藏
Antiviral CD19+CD27+ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpesvirus Infection Dhanushkodi, Nisha R.; Prakash, Swayam; Srivastava, Ruchi; Coulon, Pierre-Gregoire A.; Arellano, Danielle; Kapadia, Rayomand, V; Fahim, Raian; Suzer, Berfin; Jamal, Leila; Vahed, Hawa; BenMohamed, Lbachir 分享 收藏
Genome-Wide B Cell, CD4+, and CD8+ T Cell Epitopes That Are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-Coronavirus Vaccines Prakash, Swayam; Srivastava, Ruchi; Coulon, Pierre-Gregoire; Dhanushkodi, Nisha R.; Chentoufi, Aziz A.; Tifrea, Delia F.; Edwards, Robert A.; Figueroa, Cesar J.; Schubl, Sebastian D.; Hsieh, Lanny; Buchmeier, Michael J.; Bouziane, Mohammed; Nesburn, Anthony B.; Kuppermann, Baruch D.; BenMohamed, Lbachir 分享 收藏
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Unique molecular signatures of antiviral memory-CD8+ T cells associated with asymptomatic recurrent ocular herpes Prakash, Swayam; Roy, Soumyabrata; Srivastava, Ruchi; Coulon, Pierre-Gregoire; Dhanushkodi, Nisha R.; Vahed, Hawa; Jankeel, Allen; Geertsema, Roger; Amezquita, Cassandra; Lan Nguyen; Messaoudi, Ilhem; Burkhardt, Amanda M.; BenMohamed, Lbachir 分享 收藏