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Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice 基于大豆油的HFD诱导肠道生态失调，导致小鼠脂肪变性，肝脏炎症和胰岛素抵抗 Jacob, Texy; Sindhu, Sardar; Hasan, Amal; Malik, Md. Zubbair; Arefanian, Hossein; Al-Rashed, Fatema; Nizam, Rasheeba; Kochumon, Shihab; Thomas, Reeby; Bahman, Fatemah; Shenouda, Steve; Wilson, Ajit; Akther, Nadeem; Al-Roub, Areej; Abukhalaf, Nermeen; Albeloushi, Shaima; Abu-Farha, Mohamed; Al Madhoun, Ashraf; Alzaid, Fawaz; Thanaraj, Thangavel Alphonse; Koistinen, Heikki A.; Tuomilehto, Jaakko; Al-Mulla, Fahd; Ahmad, Rasheed 分享 收藏
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Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice Kochumon, Shihab; Malik, Md. Zubbair; Sindhu, Sardar; Arefanian, Hossein; Jacob, Texy; Bahman, Fatemah; Nizam, Rasheeba; Hasan, Amal; Thomas, Reeby; Al-Rashed, Fatema; Shenouda, Steve; Wilson, Ajit; Albeloushi, Shaima; Almansour, Nourah; Alhamar, Ghadeer; Al Madhoun, Ashraf; Alzaid, Fawaz; Thanaraj, Thangavel Alphonse; Koistinen, Heikki A.; Tuomilehto, Jaakko; Al-Mulla, Fahd; Ahmad, Rasheed 分享 收藏
ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages Ventresca, Christa; Varshney, Arushi; Orchard, Peter; Tsan, Yao-Chang; Da Rocha, Andre Monteiro; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Herron, Todd J.; Bielas, Stephanie; Parker, Stephen 分享 收藏
Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle Epelle, Ibiere L.; Varshney, Arushi; Orchard, Peter; Zhang, Zhenhao; Feng, Fan; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Liu, Jie; Parker, Stephen C. 分享 收藏
Population-Scale Single-Nucleus Skeletal Muscle Chromatin Dynamics and Nucleosome Positioning in the Context of Type 2 Diabetes Wang, Xiaoou; Robertson, Cassie; Varshney, Arushi; Manickam, Nandini; Orchard, Peter; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen 分享 收藏
Differential Cell-Type-Specific Gene Expression and Chromatin Accessibility by Type 2 Diabetes Status and Physical Activity Levels in Human Skeletal Muscle Ciotlos, Dan; Hanks, Sarah; Varshney, Arushi; Erdos, Michael; Manickam, Nandini; Stringham, Heather M.; Hill-Burns, Erin; Orchard, Peter; Narisu, Narisu; Bonnycastle, Lori L.; Sweeney, Michael D.; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen; Scott, Laura 分享 收藏
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Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells Vu, Ha T. H.; Varshney, Arushi; Orchard, Peter; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen C. 分享 收藏
Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation Varshney, Arushi; Manickam, Nandini; Orchard, Peter; Tovar, Adelaide; Zhang, Zhenhao; Feng, Fan; Lakka, Timo A.; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Mohlke, Karen L.; Kitzman, Jacob; Koistinen, Heikki A.; Liu, Jie; Boehnke, Michael; Collins, Francis S.; Scott, Laura; Parker, Stephen C. 分享 收藏
Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types Moo, Keagan G.; Albanus, Ricardo D'Oliveira; Varshney, Arushi; Orchard, Peter; Manickam, Nandini; Laakso, Markku, Sr.; Tuomilehto, Jaakko; Lakka, Timo A.; Mohlke, Karen L.; Boehnke, Michael; Scott, Laura; Koistinen, Heikki A.; Collins, Francis S.; Parker, Stephen 分享 收藏
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Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes 2型糖尿病患者的骨生物标志物 (骨促激素，核因子 κ-Β 配体的受体激活剂和糖蛋白非转移性黑色素瘤蛋白B) 水平的种族差异 Cherian, Preethi; Al-Khairi, Irina; Abu-Farha, Mohamed; Alramah, Tahani; Albatineh, Ahmed N.; Alhomaidah, Doha; Safadi, Fayez; Ali, Hamad; Abdul-Ghani, Muhammad; Tuomilehto, Jaakko; Koistinen, Heikki A.; Al-Mulla, Fahd; Abubaker, Jehad 分享 收藏
Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait 评估居住在科威特的多种族人群中硬化蛋白水平与肥胖和2型糖尿病的相关性 Alramah, Tahani; Cherian, Preethi; Al-Khairi, Irina; Abu-Farha, Mohamed; Thanaraj, Thangavel Alphonse; Albatineh, Ahmed N.; Safadi, Fayez; Ali, Hamad; Abdul-Ghani, Muhammad; Tuomilehto, Jaakko; Koistinen, Heikki A.; Al-Mulla, Fahd; Abubaker, Jehad 分享 收藏
Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families Hebbar, Prashantha; Nizam, Rasheeba; John, Sumi Elsa; Antony, Dinu; Dashti, Mohammad; Channanath, Arshad; Shaltout, Azza; Al-Khandari, Hessa; Koistinen, Heikki A.; Tuomilehto, Jaakko; Alsmadi, Osama; Thanaraj, Thangavel Alphonse; Al-Mulla, Fahd 分享 收藏
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake 全基因组关联研究和功能表征确定胰岛素刺激葡萄糖摄取的候选基因 Williamson, Alice; Norris, Dougall M.; Yin, Xianyong; Broadaway, K. Alaine; Moxley, Anne H.; Vadlamudi, Swarooparani; Wilson, Emma P.; Jackson, Anne U.; Ahuja, Vasudha; Andersen, Mette K.; Arzumanyan, Zorayr; Bonnycastle, Lori L.; Bornstein, Stefan R.; Bretschneider, Maxi P.; Buchanan, Thomas A.; Chang, Yi-Cheng; Chuang, Lee-Ming; Chung, Ren-Hua; Clausen, Tine D.; Damm, Peter; Delgado, Graciela E.; de Mello, Vanessa D.; Dupuis, Josee; Dwivedi, Om P.; Erdos, Michael R.; Silva, Lilian Fernandes; Frayling, Timothy M.; Gieger, Christian; Goodarzi, Mark O.; Guo, Xiuqing; Gustafsson, Stefan; Hakaste, Liisa; Hammar, Ulf; Hatem, Gad; Herrmann, Sandra; Hojlund, Kurt; Horn, Katrin; Hsueh, Willa A.; Hung, Yi-Jen; Hwu, Chii-Min; Jonsson, Anna; Karhus, Line L.; Kleber, Marcus E.; Kovacs, Peter; Lakka, Timo A.; Lauzon, Marie; Lee, I-Te; Lindgren, Cecilia M.; Lindstrom, Jaana; Linneberg, Allan; Liu, Ching-Ti; Luan, Jian'an; Aly, Dina Mansour; Mathiesen, Elisabeth; Moissl, Angela P.; Morris, Andrew P.; Narisu, Narisu; Perakakis, Nikolaos; Peters, Annette; Prasad, Rashmi B.; Rodionov, Roman N.; Roll, Kathryn; Rundsten, Carsten F.; Sarnowski, Chloe; Savonen, Kai; Scholz, Markus; Sharma, Sapna; Stinson, Sara E.; Suleman, Sufyan; Tan, Jingyi; Taylor, Kent D.; Uusitupa, Matti; Vistisen, Dorte; Witte, Daniel R.; Walther, Romy; Wu, Peitao; Xiang, Anny H.; Zethelius, Bjorn; Ahlqvist, Emma; Bergman, Richard N.; Chen, Yii-Der Ida; Collins, Francis S.; Fall, Tove; Florez, Jose C.; Fritsche, Andreas; Grallert, Harald; Groop, Leif; Hansen, Torben; Koistinen, Heikki A.; Komulainen, Pirjo; Laakso, Markku; Lind, Lars; Loeffler, Markus; Maerz, Winfried; Meigs, James B.; Raffel, Leslie J.; Rauramaa, Rainer; Rotter, Jerome I.; Schwarz, Peter E. H.; Stumvoll, Michael; Sundstrom, Johan; Toenjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Wagner, Robert; Barroso, Ines; Walker, Mark; Grarup, Niels; Boehnke, Michael; Wareham, Nicholas J.; Mohlke, Karen L.; Wheeler, Eleanor; O'Rahilly, Stephen; Fazakerley, Daniel J.; Langenberg, Claudia 分享 收藏
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