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收藏分享 收藏 分享 收藏 分享 收藏 Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics
Yap, Chloe X.; Vo, Daniel D.; Heffel, Matthew G.; Bhattacharya, Arjun; Wen, Cindy; Yang, Yuanhao; Kemper, Kathryn E.; Zeng, Jian; Zheng, Zhili; Zhu, Zhihong; Hannon, Eilis; Vellame, Dorothea Seiler; Franklin, Alice; Caggiano, Christa; Wamsley, Brie; Geschwind, Daniel H.; Zaitlen, Noah; Gusev, Alexander; Pasaniuc, Bogdan; Mill, Jonathan; Luo, Chongyuan; Gandal, Michael J. 分享 收藏 Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits对超过100万名欧洲血统的个体进行全基因组分析，提高了血压性状的多基因风险评分Keaton, Jacob M.; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; Goleva, Slavina B.; Ani, Alireza; Evangelou, Evangelos; Hellwege, Jacklyn N.; Yengo, Loic; Young, William J.; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; Chasman, Daniel I.; Morris, Andrew P.; Caulfield, Mark J.; Hwang, Shih-Jen; Kooner, Jaspal S.; Conen, David; Attia, John R.; Morrison, Alanna C.; Loos, Ruth J. F.; Kristiansson, Kati; Schmidt, Reinhold; Hicks, Andrew A.; Pramstaller, Peter P.; Nelson, Christopher P.; Samani, Nilesh J.; Risch, Lorenz; Gyllensten, Ulf; Melander, Olle; Riese, Harriette; Wilson, James F.; Campbell, Harry; Rich, Stephen S.; Psaty, Bruce M.; Lu, Yingchang; Rotter, Jerome I.; Guo, Xiuqing; Rice, Kenneth M.; Vollenweider, Peter; Sundstrom, Johan; Langenberg, Claudia; Tobin, Martin D.; Giedraitis, Vilmantas; Luan, Jian'an; Tuomilehto, Jaakko; Kutalik, Zoltan; Ripatti, Samuli; Salomaa, Veikko; Girotto, Giorgia; Trompet, Stella; Jukema, J. Wouter; van der Harst, Pim; Ridker, Paul M.; Giulianini, Franco; Vitart, Veronique; Goel, Anuj; Watkins, Hugh; Harris, Sarah E.; Deary, Ian J.; van der Most, Peter J.; Oldehinkel, Albertine J.; Keavney, Bernard D.; Hayward, Caroline; Campbell, Archie; Boehnke, Michael; Scott, Laura J.; Boutin, Thibaud; Mamasoula, Chrysovalanto; Jarvelin, Marjo-Riitta; Peters, Annette; Gieger, Christian; Lakatta, Edward G.; Cucca, Francesco; Hui, Jennie; Knekt, Paul; Enroth, Stefan; De Borst, Martin H.; Polasek, Ozren; Concas, Maria Pina; Catamo, Eulalia; Cocca, Massimiliano; Li-Gao, Ruifang; Hofer, Edith; Schmidt, Helena; Spedicati, Beatrice; Waldenberger, Melanie; Strachan, David P.; Laan, Maris; Teumer, Alexander; Dorr, Marcus; Gudnason, Vilmundur; Cook, James P.; Ruggiero, Daniela; Kolcic, Ivana; Boerwinkle, Eric; Traglia, Michela; Lehtimaki, Terho; Raitakari, Olli T.; Johnson, Andrew D.; Newton-Cheh, Christopher; Brown, Morris J.; Dominiczak, Anna F.; Sever, Peter J.; Poulter, Neil; Chambers, John C.; Elosua, Roberto; Siscovick, David; Esko, Tonu; Metspalu, Andres; Strawbridge, Rona J.; Laakso, Markku; Hamsten, Anders; Hottenga, Jouke-Jan; de Geus, Eco; Morris, Andrew D.; Palmer, Colin N. A.; Nolte, Ilja M.; Milaneschi, Yuri; Marten, Jonathan; Wright, Alan; Zeggini, Eleftheria; Howson, Joanna M. M.; O'Donnell, Christopher J.; Spector, Tim; Nalls, Mike A.; Simonsick, Eleanor M.; Liu, Yongmei; van Duijn, Cornelia M.; Butterworth, Adam S.; Danesh, John N.; Menni, Cristina; Wareham, Nicholas J.; Khaw, Kay-Tee; Sun, Yan V.; Wilson, Peter W. F.; Cho, Kelly; Visscher, Peter M.; Denny, Joshua C.; Levy, Daniel; Edwards, Todd L.; Munroe, Patricia B.; Snieder, Harold; Warren, Helen R. 分享 收藏 Genetic control of DNA methylation is largely shared across European and East Asian populationsDNA甲基化的遗传控制在欧洲和东亚人群中普遍存在Hatton, Alesha A.; Cheng, Fei-Fei; Lin, Tian; Shen, Ren-Juan; Chen, Jie; Zheng, Zhili; Qu, Jia; Lyu, Fan; Harris, Sarah E.; Cox, Simon R.; Jin, Zi-Bing; Martin, Nicholas G.; Fan, Dongsheng; Montgomery, Grant W.; Yang, Jian; Wray, Naomi R.; Marioni, Riccardo E.; Visscher, Peter M.; Mcrae, Allan F. 分享 收藏 LEVERAGING FUNCTIONAL GENOMIC ANNOTATIONS AND GENOME COVERAGE TO IMPROVE POLYGENIC PREDICTION OF COMPLEX TRAITS WITHIN AND BETWEEN ANCESTRIESZeng, Jian; Zheng, Zhili; Liu, Shouye; Sidorenko, Julia; Yengo, Loic; Turley, Patrick; Ani, Alireza; Wang, Rujia; Nolte, Ilja; Snieder, Harold; Yang, Jian; Wray, Naomi; Goddard, Michael; Visscher, Peter 分享 收藏 Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traitsLi, Jinghui; Zhao, Tianjing; Guan, Dailu; Pan, Zhangyuan; Bai, Zhonghao; Teng, Jinyan; Zhang, Zhe; Zheng, Zhili; Zeng, Jian; Zhou, Huaijun; Fang, Lingzhao; Cheng, Hao 分享 收藏 mBAT-combo: A more powerful test to detect gene-trait associations from GWAS dataLi, Ang; Liu, Shouye; Bakshi, Andrew; Jiang, Longda; Chen, Wenhan; Zheng, Zhili; Sullivan, Patrick F.; Visscher, Peter M.; Wray, Naomi R.; Yang, Jian; Zeng, Jian 分享 收藏 Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data从全基因组序列数据评估罕见变异对复杂性状遗传力的贡献Wainschtein, Pierrick; Jain, Deepti; Zheng, Zhili; Cupples, L. Adrienne; Shadyab, Aladdin H.; McKnight, Barbara; Shoemaker, Benjamin M.; Mitchell, Braxton D.; Psaty, Bruce M.; Kooperberg, Charles; Liu, Ching-Ti; Albert, Christine M.; Roden, Dan; Chasman, Daniel, I; Darbar, Dawood; Lloyd-Jones, Donald M.; Arnett, Donna K.; Regan, Elizabeth A.; Boerwinkle, Eric; Rotter, Jerome, I; O'Connell, Jeffrey R.; Yanek, Lisa R.; de Andrade, Mariza; Allison, Matthew A.; Mcdonald, Merry-Lynn N.; Chung, Mina K.; Fornage, Myriam; Chami, Nathalie; Smith, Nicholas L.; Ellinor, Patrick T.; Vasan, Ramachandran S.; Mathias, Rasika A.; Loos, Ruth J. F.; Rich, Stephen S.; Lubitz, Steven A.; Heckbert, Susan R.; Redline, Susan; Guo, Xiuqing; Chen, Y-D Ida; Laurie, Cecelia A.; Hernandez, Ryan D.; McGarvey, Stephen T.; Goddard, Michael E.; Laurie, Cathy C.; North, Kari E.; Lange, Leslie A.; Weir, Bruce S.; Yengo, Loic; Yang, Jian; Visscher, Peter M. 分享 收藏 分享 收藏 A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple CohortsNi, Guiyan; Zeng, Jian; Revez, Joana A.; Wang, Ying; Zheng, Zhili; Ge, Tian; Restuadi, Restuadi; Kiewa, Jacqueline; Nyholt, Dale R.; Coleman, Jonathan R., I; Smoller, Jordan W.; Yang, Jian; Visscher, Peter M.; Wray, Naomi R. 分享 收藏 分享 收藏 Widespread signatures of natural selection across human complex traits and functional genomic categoriesZeng, Jian; Xue, Angli; Jiang, Longda; Lloyd-Jones, Luke R.; Wu, Yang; Wang, Huanwei; Zheng, Zhili; Yengo, Loic; Kemper, Kathryn E.; Goddard, Michael E.; Wray, Naomi R.; Visscher, Peter M.; Yang, Jian 分享 收藏 分享 收藏 A unified framework for association and prediction from vertex-wise grey-matter structure基于顶点的灰色物质结构的关联和预测的统一框架Couvy-Duchesne, Baptiste; Strike, Lachlan T.; Zhang, Futao; Holtz, Yan; Zheng, Zhili; Kemper, Kathryn E.; Yengo, Loic; Colliot, Olivier; Wright, Margaret J.; Wray, Naomi R.; Yang, Jian; Visscher, Peter M. 分享 收藏 Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic dataWu, Yang; Qi, Ting; Wang, Huanwei; Zhang, Futao; Zheng, Zhili; Phillips-Cremins, Jennifer E.; Deary, Ian J.; McRae, Allan F.; Wray, Naomi R.; Zeng, Jian; Yang, Jian 分享 收藏 分享 收藏 Improved polygenic prediction by Bayesian multiple regression on summary statisticsLloyd-Jones, Luke R.; Zeng, Jian; Sidorenko, Julia; Yengo, Loic; Moser, Gerhard; Kemper, Kathryn E.; Wang, Huanwei; Zheng, Zhili; Magi, Reedik; Esko, Tonu; Metspalu, Andres; Wray, Naomi R.; Goddard, Michael E.; Yang, Jian; Visscher, Peter M. 分享 收藏 
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