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魏珂 (Wei, Ke)
H指数:0
被引数:0
个人简介
"魏珂，同济大学生命科学与技术学院教授，附属东方医院心脏病全国重点实验室特聘研究员。本科毕业于清华大学生物科学与技术系，于美国加利福尼亚大学洛杉矶分校分子细胞综合生理专业获得博士学位，后在美国桑福德伯纳姆普利贝司医学研究所进行博士后科学研究。入选国家高层次人才青年项目，主持并参与多项国家自然科学基金项目及科技部重点研发项目。主要研究方向为心脏发育与再生，通过基于干细胞来源心肌细胞的体外高内涵筛选和体内发育和心脏疾病模型，发现了调控心肌细胞成熟与增殖，肥大与萎缩等多种表型转换的新机制；为开发治疗心脏疾病、促进心脏再生的药物提供了新的方向。发表SCI论文40余篇，其中以第一作者及通讯作者发表包括Nature, Circulation, Cell Research, Cardiovasc Res, Protein & Cell在内的论文20余篇，并获得两项美国专利授权。\n研究领域（具体内容）：干细胞与再生生物学心肌梗死疾病模型与转化医学高内涵药物筛选\n发表论文\n2026\nMengying Feng#, Yansong Tang#, Su Yao, Hongjie Zhang, Bilin Liu, Rongrong Huang, Shiqi Huang, Zhaohui Ouyang, Min Yuan, Rui Jiang, Dachun Xu, Guohua Gong, Ke Wei* “Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating canonical Wnt signaling pathway” (2026) Acta Pharmacologica Sinica 47(4):917-931\n2025\nRui Jiang#, Hao Wang#, Weina Zhang, Jiaxi Li, Shiqi Huang, Lingjiang Chen, Yuhan Min, Zhaohui Ouyang, Ying Jiang, Zhiyong Mao, Guizhu Wu*, Ke Wei*, Yu Chen* “DHT Ameliorates Cardiac Aging in Progeroid Mice by XRCC4-Mediated Genome Stabilization” (2025) Mechanisms of Ageing and Development 112141\nDandan Zhang#, Yansong Tang#, Wen Ye#, Danli Yang, Shengtang Qin, Juntao Liu, Nan Su, Rongrong Huang, Guangzheng Shi, Dachun Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Shaorong Gao*, Ke Wei*, Lan Kang*, “Pkm1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability” (2025) National Science Review 13 (1), nwaf408 https://doi.org/10.1093/nsr/nwaf408\nKuisheng Liu#, Zihui Yan#, Dandan Bai#, Rui Jiang#, Yan Bi#, Xiangjun Ma#, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, Yalin Zhang, Yanhe Li, Tao Wu, Chenxiang Xi, Shanyao Liu, Shuyi Liu, Jiayu Chen, Jiqing Yin, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yixuan Wang*, Ke Wei*, Shaorong Gao*, Wenqiang Liu*, “Modeling post-gastrula development via bidirectional pluripotent stem cells” (2025) Cell Research 35(12):954-969, doi.org/10.1038/s41422-025-01172-x\nRui Jiang, Jiayu Chen, Lijuan Pei, Shiqi Huang, Mengying Feng, Zhaohui Ouyang, Min Yuan, Yalin Zhu, Su Yao, Fenglian He, Hongjie Zhang, Xin Dong, Peng Xie*, Ke Wei*, “Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification” (2025) European Journal of Cell Biology 104(3):151504\nJingjing He#, Yi Yang#, Rui Jiang#, Yanying Zheng#, Xianfa Yang, Xu Jiang, Xin Xue, Zhongzhou Yang, Naihe Jing, Hailong Cao*, Zhuojuan Luo*, Ke Wei*, Peng Xie*, Chengqi Lin* “Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors” (2025) Genome Biology 26(1):158\n2024\nRui Jiang, Lijuan Pei, Hongjie Zhang, Fenglian He, Yuhan Min, Xinhang Li, Ke Wei* “miR-199a-3p suppresses Vldlr expression to promote cardiomyocyte proliferation” (2024) Acta Biochimica et Biophysica Sinica 57(7):1164-1174\nYihang Zhou#, Jihong Zheng#, Wenqi Song#, Xinyi Yan, Li Du, Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian, Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei*, Chao Zhang*, Jiangtao Li*, Xiaozhu Wang* “OUTPOST: A comprehensive analysis software for whole-metagenome shotgun sequencing incorporating group stratification” (2024) iMetaOmics 2024:e29\nSu Yao, Yalin Zhu, Fenglian He, Min Yuan, Rui Jiang, Hongjie Zhang, Yanbin Fu, Ke Wei* “JAK Activity Regulates Mesoderm Cell Fate by controlling MESP1 expression” (2024) European Journal of Cell Biology 103(4):151452\nXinhang Li, Yalin Zhu, Pilar Ruiz-Lozano*, Ke Wei* “Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation” (2024) Cell Regeneration 13(1), 2\n2023\nLijuan Pei#, Zhaohui Ouyang#, Hongjie Zhang, Shiqi Huang, Rui Jiang, Bilin Liu, Yansong Tang, Mengying Feng, Min Yuan, Haocun Wang, Su Yao, Shuyue Shi, Zhao Yu, Dachun Xu, Guohua, Gong, Ke Wei* “Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair” (2023) Basic Research in Cardiology 119(1):169-192\nYansong Tang, Mengying Feng, Dachun Xu, Ke Wei* “Response by Tang et al to Letter Regarding Article, “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy”” (2023) Circulation 148 (24), 1980-1981\nYu Chen#, Shiqi Huang#, Zhen Cui, Xiaoxiang Sun, Yansong Tang, Hongjie Zhang, Zhixi Chen, Rui Jiang, Weina Zhang, Xue Li, Jiayu Chen, Baohua Liu, Ying Jiang, Ke Wei*, Zhiyong Mao* “Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model” (2023) Proceedings of the National Academy of Sciences 120(47):e2309200120\nYansong Tang#, Mengying Feng#, Yang Su, Teng Ma, Hongjie Zhang, Hongchun Wu, Xiaoyu Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei*, Dachun Xu* “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy” (2023) Circulation 147(22):1684–1704\nShuangshuang Zhao#, Qiuping Xu#, Yanqin Cui#, Su Yao, Sihui Jin, Qian Zhang, Zeyu Wen, Haihua Ruan, Xin Liang, Yanjie Chao, Sitang Gong, Philippe Sansonetti, Ke Wei*, Hong Tang*, Yaming Jiu* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection” (2023) Nature Communications 14(1), 478\nJing Zhang#, Zhaohui Ouyang#, Limei Xia, Qi Wang, Feng Zheng, Kun Xu, Yuexian Xing, Ke Wei*, Shaolin Shi*, Chaojun Li*, Jingping Yang* “Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes” (2023) Cell Death Discovery 9(1), 11\n2022\n王皓存，欧阳兆惠，魏珂* “心肌细胞的成熟及其转录调控” 中国细胞生物学学报 （2022） 44:8 1473–1483\nMengying Feng, Yansong Tang, Su Yao, Hongjie Zhang, Dachun Xu, Ke Wei* “PLK inhibitors identified by high content phenotypic screening promote maturation of human PSC-derived cardiomyocytes” (2022) Biochemical and Biophysical Research Communications 620 (2022) 113-120\nHongjie Zhang#, Lijuan Pei#, Zhaohui Ouyang, Haocun Wang, Xin Chen, Kai Jiang, Shiqi Huang, Rui Jiang, Yaozu Xiang, Ke Wei* “AP-1"
教育背景
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工作经历
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荣誉奖项
- 国家高层次人才青年项目｜国家
