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收藏Mechanisms of endocrine resistance to letrozole, fulvestrant, and palbociclib are associated with increased sensitivity to hexyl-cuban-1-yl biguanide inhibitors of CYP3A4 mediated epoxyeicosatrienoic acid biosynthesis
Guo, Zhijun; Lei, Jianxun; Makovec, Allison; Jayaraman, Swaathi; Hawse, John R.; Lange, Carol; Ambrose, Elizabeth; Georg, Gunda I.; D'Assoro, Tony; Matthew, Goetz P.; Potter, David A. 分享 收藏 分享 收藏 Impact of body mass index on pathological response after neoadjuvant chemotherapy: results from the I-SPY 2 trialWang, Haiyun; Yee, Douglas; Potter, David; Jewett, Patricia; Yau, Christina; Beckwith, Heather; Watson, Allison; O'Grady, Nicholas; Wilson, Amy; Brain, Susie; Pohlmann, Paula; Blaes, Anne 分享 收藏 Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial-Efficacy and Biomarker Discovery在适应性随机I-SPY2试验中，以Trebananib和紫杉醇为基础的新辅助化疗治疗II/III期乳腺癌的疗效和生物标志物发现Albain, Kathy S.; Yau, Christina; Petricoin, Emanuel F.; Wolf, Denise M.; Lang, Julie E.; Chien, A. Jo; Haddad, Tufia; Forero-Torres, Andres; Wallace, Anne M.; Kaplan, Henry; Pusztai, Lajos; Euhus, David; Nanda, Rita; Elias, Anthony D.; Clark, Amy S.; Godellas, Constantine; Boughey, Judy C.; Isaacs, Claudine; Tripathy, Debu; Lu, Janice; Yung, Rachel L.; Gallagher, Rosa I.; Wulfkuhle, Julia D.; Brown-Swigart, Lamorna; Krings, Gregor; Chen, Yunn Yi; Potter, David A.; Stringer-Reasor, Erica; Blair, Sarah; Asare, Smita M.; Wilson, Amy; Hirst, Gillian L.; Singhrao, Ruby; Buxton, Meredith; Clennell, Julia L.; Sanil, Ashish; Berry, Scott; Asare, Adam L.; Matthews, Jeffrey B.; Demichele, Angela M.; Hylton, Nola M.; Melisko, Michelle; Perlmutter, Jane; Rugo, Hope S.; Symmans, W. Fraser; van't Veer, Laura J.; Yee, Douglas; Berry, Donald A.; Esserman, Laura J. 分享 收藏 Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral regulatory T cells, and increases intratumoral CD8+T cells in the ovarian dependent ER+HER2-SSM2ucd mammary cancer allograft modelGuo, Zhijun; Lei, Jianxun; Venkatesh, Hrishi; Owen, David; Bass, Adam; Cannon, Christine; McCarra, Joshua; Koniar, Brenda; Flory, Craig; Norris, Beverly; Schumacher, Robert J.; Jayaraman, Swaathi; Hawse, John; Antonarakis, Emmanuel S.; Petricoin, Emanuel F.; Wulfkuhle, Julia; Cardiff, Robert D.; Ambrose, Elizabeth A.; Georg, Gunda I.; Schwertfeger, Kaylee L.; Farrar, Michael A.; Croix, Brad St.; Goetz, Matthew P.; Potter, David A. 分享 收藏 Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (vol 24, pg 2499, 2004)Glading, A; Bodnar, RJ; Reynolds, IJ; Shiraha, H; Satish, L; Potter, DA; Blair, HC; Wells, A 分享 收藏 Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylationGlading, A; Bodnar, RJ; Reynolds, IJ; Shiraha, H; Satish, L; Potter, DA; Blair, HC; Wells, A 分享 收藏 分享 收藏 Evaluation of Tucatinib plus (Paclitaxel plus Pertuzumab plus Trastuzumab) followed by AC in high-risk HER2 positive (HER2+) stage II/III breast cancer: Results from the I-SPY 2 TRIALPotter, David A.; Roesch, Erin; Yau, Christina; Lu, Ruixiao; Wolf, Denise; Samson, Susan; Stafford, Debra; Albain, Kathy S.; Isaacs, Claudine; Trivedi, Meghana; Yee, Douglas; Boughey, Judy; Thomas, Alexandra; Chien, A. Jo; Hylton, Nola; Li, Wen; DeMichele, Angela; Perlmutter, Jane; Symmans, W. Fraser; Hershman, Dawn L.; Melisko, Michelle; Veer, Laura J. van ' t; Wilson, Amy; Asare, Smita M.; Berry, Donald A.; Schwab, Richard; Rugo, Hope S.; Esserman, Laura J. 分享 收藏 分享 收藏 分享 收藏 Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast CancerLim, Bora; Potter, David A.; Salkeni, Mohamad A.; Silverman, Paula; Haddad, Tufia C.; Forget, Frederic; Awada, Ahmad; Canon, Jean-Luc; Danso, Michael; Lortholary, Alain; Bourgeois, Hugues; Tan-Chiu, Elizabeth; Vincent, Sylvie; Bahamon, Brittany; Galinsky, Kevin J.; Patel, Chirag; Neuwirth, Rachel; Leonard, E. Jane; Diamond, Jennifer R. 分享 收藏 分享 收藏 Metformin inhibits nuclear localization of estrogen receptor alpha in breast cancer cells, in part, by inhibition of CYP-mediated epoxyeicosatrienoic acid (EET) biosynthesisGuo, Zhijun; Lei, Jianxun; Wu, Shaoping; Molina-Vega, Julissa; Cervantes, Paloma; Rom'Mand, Aline R.; Mijangos, Dylan C. Castillejo; Falck, John R.; Lange, Carol; Wang, Jinhua; Potter, David A. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Phase 2 safety and efficacy results of TAK-228 in combination with exemestane or fulvestrant in postmenopausal women with ERpositive/HER2-negative metastatic breast cancer previously treated with everolimusDiamond, J. R.; Potter, D.; Salkeni, M.; Silverman, P.; Haddad, T.; Forget, F.; Awada, A.; Canon, J-L; Danso, M.; Lortholary, A.; Bourgeois, H.; Tan-Chiu, E.; Patel, C.; Neuwirth, R.; Leonard, E. J.; Lim, B. 分享 收藏 分享 收藏 
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