未登录 Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer Menegollo, Michela; Bentham, Robert B.; Henriques, Tiago; Ng, Seow Q.; Ren, Ziyu; Esculier, Clarinde; Agarwal, Sia; Tong, Emily T. Y.; Lo, Clement; Ilangovan, Sanjana; Szabadkai, Zorka; Suman, Matteo; Patani, Neill; Ghanate, Avinash; Bryson, Kevin; Stein, Robert C.; Yuneva, Mariia; Szabadkai, Gyorgy 分享 收藏
Can high progesterone receptor (PgR) expression identify tumours with low-risk tumour gene expression scores? Stein, Robert; Wirtz, Ralph; Marshall, Andrea; Bayani, Jane; Eidt, Sebastian; Schumacher, Claudia; Sinn, Hans-Peter; Schneeweiss, Andreas; Makris, Andreas; Macpherson, Iain; Hughes-Davies, Luke; Piper, Tammy; Sobol, Monika; Dotchin, Georgina; Higgins, Helen; Pinder, Sarah; Shaaban, Abeer; Dunn, Janet; Bartlett, John M. S. 分享 收藏
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OPTIMA, a prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in high clinical risk early breast cancer Stein, Robert; Makris, Andreas; Macpherson, Iain; Hughes-Davies, Luke; Marshall, Andrea; Dotchin, Georgina; Cameron, David A.; Kiely, Belinda E.; Wilson, Caroline; Armstrong, Anne; Earl, Helena M.; Poole, Christopher J.; Tsang, Janice; Naume, Bjorn; Rea, Daniel; Ohnstad, Hege; Hall, Peter S.; McIntosh, Stuart A.; Shinkins, Bethany; McCabe, Christopher; Morgan, Adrienne; Bartlett, John M. S.; Dunn, Janet A. 分享 收藏
Comparative survival analysis of multiparametric tests-when molecular tests disagree-A TEAM Pathology study Bartlett, John M. S.; Bayani, Jane; Kornaga, Elizabeth; Xu, Keying; Pond, Greg R.; Piper, Tammy; Mallon, Elizabeth; Yao, Cindy Q.; Boutros, Paul C.; Hasenburg, Annette; Dunn, J. A.; Markopoulos, Christos; Dirix, Luc; Seynaeve, Caroline; van de Velde, Cornelis J. H.; Stein, Robert C.; Rea, Daniel 分享 收藏
Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer Conefrey, C.; Donovan, J. L.; Stein, R. C.; Paramasivan, S.; Marshall, A.; Bartlett, J.; Cameron, D.; Campbell, A.; Dunn, J.; Earl, H.; Hall, P.; Harmer, V; Hughes-Davies, L.; Macpherson, I; Makris, A.; Morgan, A.; Pinder, S.; Poole, C.; Rea, D.; Rooshenas, L. 分享 收藏
OPTIMA: A prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in mostly node-positive early breast cancer Stein, Robert C.; Marshall, Andrea; Makris, Andreas; Hughes-Davies, Luke; MacPherson, Iain R.; Conefrey, Carmel; Rooshenas, Leila; Pinder, Sarah E.; Shaaban, Abeer M.; Naume, Bjorn; Cameron, David A.; Rea, Daniel W.; Earl, Helena M.; Poole, Christopher J.; Hall, Peter S.; Dotchin, Georgina; McIntosh, Stuart A.; Harmer, Victoria; Morgan, Adrienne; Shinkins, Bethany; Stallard, Nigel; McCabe, Christopher; Donovan, Jenny L.; Bartlett, John M. S.; Dunn, Janet A. 分享 收藏
Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis Harnan, Sue; Tappenden, Paul; Cooper, Katy; Stevens, John; Bessey, Alice; Rafia, Rachid; Ward, Sue; Wong, Ruth; Stein, Robert C.; Brown, Janet 分享 收藏
PALLET: A neoadjuvant study to compare the clinical and antiproliferative effects of letrozole with and without palbociclib Dowsett, M.; Jacobs, S.; Johnston, S.; Bliss, J.; Wheatley, D.; Holcombe, C.; Stein, R.; McIntosh, S.; Barry, P.; Dolling, D.; Snowdon, C.; Perry, S.; Batten, L.; Dodson, A.; Martins, V.; Modi, A.; Cornman, C.; Puhalla, S.; Wolmark, N.; Julian, T.; Pogue-Geile, K.; Robidoux, A.; Provencher, L.; Boileau, J. F.; Shalaby, I.; Thirlwell, M.; Fisher, K.; Bartlett, C. Huang; Koehler, M.; Osborne, K.; Rimawi, M. 分享 收藏
OPTIMA: A prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in high clinical risk early breast cancer Stein, R. C.; Hughes-Davies, L.; Makris, A.; Macpherson, I. R.; Conefrey, C.; Rooshenas, L.; Pinder, S. E.; Thomas, J.; Hall, P. S.; Cameron, D. A.; Earl, H. M.; Naume, B.; Poole, C. J.; Rea, D. W.; MacIntosh, S. A.; Harmer, V.; Morgan, A.; Hulme, C.; McCabe, C.; Stallard, N.; Higgins, H.; Donovan, J. L.; Bartlett, J. M.; Marshall, A.; Dunn, J. A. 分享 收藏
The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation 五重奏招募干预支持五项随机试验招募目标: 混合方法评估 Rooshenas, Leila; Scott, Lauren J.; Blazeby, Jane M.; Rogers, Chris A.; Tilling, Kate M.; Husbands, Samantha; Conefrey, Carmel; Mills, Nicola; Stein, Robert C.; Metcalfe, Chris; Carr, Andrew J.; Beard, David J.; Davis, Tim; Paramasivan, Sangeetha; Jepson, Marcus; Avery, Kerry; Elliott, Daisy; Wilson, Caroline; Donovan, Jenny L.; Andrews, Robert; Byrne, James; Kelly, Jamie; Mazza, Graziella; Mahon, David; Noble, Hamish; Reeves, Barnaby C.; Thompson, Janice L.; Wordsworth, Sarah; Welbourn, Richard; Beard, David; Carr, Andrew; Cook, Jonathan; Cooper, Cushla; Dean, Benjamin; Gray, Alastair; Gwilym, Stephen; Judge, Andrew; Merritt, Naomi; Moser, Jane; Rees, Jonathan; Rombach, Ines; Savulescu, Julian; Tracey, Irene; Wartolowska, Karolina; Harrison, Eleanor; Tan, Wei; Karantana, Alexia; Sprange, Kirsty; Duley, Lelia; Hollingworth, William; Montgomery, Alan A.; Stein, Rob; Bartlett, John; Cameron, David; Campbell, Amy; Canney, Peter; Dunn, Janet; Earl, Helena; Falzon, Mary; Francis, Adele; Hall, Peter; Harmer, Victoria; Higgins, Helen; Hiller, Louise; Hughes-Davies, Luke; Hulme, Claire; Macpherson, Iain; Makris, Andreas; Marshall, Andrea; McCabe, Christopher; Morgan, Adrienne; Pinder, Sarah; Poole, Christopher; Provenzano, Elena; Rea, Daniel; Stallard, Nigel; Avery, Kerry N. L.; Barham, C. Paul; Berrisford, Richard; Elliott, Jackie; Falk, Stephen J.; Goldin, Rob; Hanna, George; Hollowood, Andrew A.; Krysztopik, Richard; Noble, Sian; Sanders, Grant; Streets, Christopher G.; Titcomb, Dan R.; Wheatley, Tim 分享 收藏
Value of Information Analysis of Multiparameter Tests for Chemotherapy in Early Breast Cancer: The OPTIMA Prelim Trial Hall, Peter S.; Smith, Alison; Hulme, Clarire; Vargas-Palacios, Armando; Makris, Andreas; Hughes-Davies, Luke; Dunn, Janet A.; Bartlett, John M. S.; Cameron, David A.; Marshall, Andrea; Campbell, Amy; Macpherson, Iain R.; Rea, Dan; Francis, Adele; Earl, Helena; Morgan, Adrienne; Stein, Robert C.; McCabe, Christopher 分享 收藏
Viewpoint: Availability of oestrogen receptor and HER2 status for the breast multidisciplinary meeting discussion; time to get it right Francis, A.; Bartlett, J.; Rea, D.; Pinder, S. E.; Stein, R. C.; Stobart, H.; Purdie, C. A.; Rakha, E.; Thompson, A.; Shaaban, A. M. 分享 收藏
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others Bartlett, John M. S.; Bayani, Jane; Marshall, Andrea; Dunn, Janet A.; Campbell, Amy; Cunningham, Carrie; Sobol, Monika S.; Hall, Peter S.; Poole, Christopher J.; Cameron, David A.; Earl, Helena M.; Rea, Daniel W.; Macpherson, Iain R.; Canney, Peter; Francis, Adele; McCabe, Christopher; Pinder, Sarah E.; Hughes-Davies, Luke; Makris, Andreas; Stein, Robert C. 分享 收藏
A phase II, double blind, randomised, placebo-controlled study of the AKT Inhibitor AZD5363 in combination with paclitaxel in triple-negative advanced or metastatic breast cancer (TNBC) (NCT02423603) Schmid, P.; Wheatley, D.; Baird, R.; Chan, S.; Abraham, J.; Tutt, A.; Kristeleit, H.; Patel, G.; Bathakur, U.; Bishop, J.; Harper-Wynne, C.; Sims, E.; Copson, E.; Perren, T.; Stein, R.; Poole, C.; Cartwright, H.; Sarker, S-J; Mousa, K.; Turner, N. 分享 收藏
NEO-EXCEL phase III neoadjuvant trial of pre-operative exemestane or letrozole plus /- celecoxib in the treatment of ER positive postmenopausal early breast cancer Rea, D.; Francis, A.; Poole, C.; Brookes, C.; Stein, R.; Bartlett, J.; Dunn, J.; Canney, P.; Sutton, R.; Daoud, R.; Hallissey, M.; Achuthan, R.; Grant, M.; Babrah, J.; Smith, S.; Fraser, J.; Desai, A.; Al Dubaisi, M.; Patel, A.; Bristol, J.; Chandrasekharan, S.; Prest, C.; Jewkes, A. 分享 收藏
ROSCO: A randomised phase III, stratified CEP17/TOP2A biomarker trial of neo-adjuvant 5-flourouracil, epirubicin and cyclophosphamide vs docetaxel and cyclophosphamide chemotherapy Rea, D. W.; Haywood, L.; Francis, A. M.; Bowden, S. J.; Brookes, C. M.; MacKenzie, M.; Cameron, D.; Stein, R.; Earl, H. M.; Thomas, J.; Abraham, J.; Stanley, A.; Starczinski, J.; McGoldrick, T.; Treharne-Jones, P.; Billingham, L.; Bartlett, J. M. 分享 收藏
OPTIMA (optimal personalised treatment of early breast cancer using multi-parameter analysis), a prospective trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions Stein, R. C.; Marshall, A.; Hall, P. S.; Bartlett, J. M. S.; Rooshenas, L.; Campbell, A.; Cameron, D. A.; Rea, D.; Macpherson, I.; Earl, H. M.; Poole, C. J.; Francis, A.; Morgan, A.; Harmer, V.; Pinder, S. E.; Stallard, N.; Donovan, J.; Hulme, C.; McCabe, C.; Hughes-Davies, L.; Makris, A.; Dunn, J. A. 分享 收藏
OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer Stein, Robert C.; Dunn, Janet A.; Bartlett, John M. S.; Campbell, Amy F.; Marshall, Andrea; Hall, Peter; Rooshenas, Leila; Morgan, Adrienne; Poole, Christopher; Pinder, Sarah E.; Cameron, David A.; Stallard, Nigel; Donovan, Jenny L.; McCabe, Christopher; Hughes-Davies, Luke; Makris, Andreas 分享 收藏
Results of the OPTIMA (Optimal Personalized Treatment of early breast cancer usIng Multi-parameter Analysis) prelim study Stein, R. C.; Makris, A.; Hughes-Davies, L.; Bartlett, J. M. S.; Marshall, A.; Hall, P. S.; Campbell, A.; Pinder, S. E.; Cameron, D. A.; Rea, D.; Earl, H.; MacPherson, I.; Poole, C.; Canney, P.; Francis, A.; Morgan, A.; Stallard, N.; Hulme, C.; McCabe, C.; Dunn, J. A. 分享 收藏
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