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Stabilizing a Native Fold of Alpha-Synuclein with Short Helix-Constrained Peptides 通过短螺旋约束肽稳定α-突触核蛋白的天然折叠结构 Meade, Richard M.; Allen, Scott G.; Lopez, Amy J.; Williams, Christopher; Thomas-Wright, Iona; Heon-Roberts, Rachel; Carey-Wood, Mara; Tang, T. M. Simon; Sero, Julia E.; Hunt, Vicky L.; Wade-Martins, Richard; Crump, Matthew P.; Mason, Jody M. 分享 收藏
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Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging 通过在体PET成像揭示的LRRK2-R1441C大鼠早期帕金森病模型中背侧纹状体的多巴胺D2受体上调 Delgado-Goni, Teresa; Connor-Robson, Natalie; Cioroch, Milena; Paisey, Stephen; Marshall, Christopher; Lane, Emma L.; Hauton, David; McCullagh, James; Magill, Peter J.; Cragg, Stephanie J.; Mackay, Clare E.; Wade-Martins, Richard; Klein, Johannes C. 分享 收藏
Changes in iPSC-astrocyte morphology reflect Alzheimer's disease patient clinical markers Rowland, Helen A.; Miller, Georgina; Liu, Qiang; Li, Shuhan; Sharp, Nicola R.; Ng, Bryan; Wei, Tina; Arunasalam, Kanisa; Koychev, Ivan; Hedegaard, Anne; Ribe, Elena M.; Chan, Dennis; Chessell, Tharani; Kocagoncu, Ece; Lawson, Jennifer; Malhotra, Paresh; Ridha, Basil H.; Rowe, James B.; Thomas, Alan J.; Zamboni, Giovanna; Zetterberg, Henrik; Cader, M. Zameel; Wade-Martins, Richard; Lovestone, Simon; Nevado-Holgado, Alejo; Kormilitzin, Andrey; Buckley, Noel J. 分享 收藏
Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation Do, Quyen B.; Noor, Humaira; Marquez-Gomez, Ricardo; Cramb, Kaitlyn M. L.; Ng, Bryan; Abbey, Ajantha; Ibarra-Aizpurua, Naroa; Caiazza, Maria Claudia; Sharifi, Parnaz; Lang, Charmaine; Beccano-Kelly, Dayne; Baleriola, Jimena; Bengoa-Vergniory, Nora; Wade-Martins, Richard 分享 收藏
Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease Kilfeather, Peter; Khoo, Jia Hui; Wagner, Katherina; Liang, Han; Caiazza, Maria Claudia; An, Yanru; Zhang, Xingju; Chen, Xiaoyan; Connor-Robson, Natalie; Shang, Zhouchun; Wade-Martins, Richard 分享 收藏
Tau depletion in human neurons mitigates Aβ-driven toxicity Ng, Bryan; Vowles, Jane; Bertherat, Feodora; Abey, Ajantha; Kilfeather, Peter; Beccano-Kelly, Dayne; Stefana, M. Irina; O'Brien, Darragh P.; Bengoa-Vergniory, Nora; Carling, Phillippa J.; Todd, John A.; Caffrey, Tara M.; Connor-Robson, Natalie; Cowley, Sally A.; Wade-Martins, Richard 分享 收藏
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Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons (vol 18, 87, 2023) Hasan, Saadia; Fernandopulle, Michael S.; Humble, Stewart W.; Frankenfield, Ashley M.; Li, Haorong; Prestil, Ryan; Johnson, Kory R.; Ryan, Brent J.; Wade-Martins, Richard; Ward, Michael E.; Hao, Ling 分享 收藏
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons 颗粒蛋白前体缺乏的神经元中溶酶体功能和蛋白稳态的多模式蛋白质组学表征 Hasan, Saadia; Fernandopulle, Michael S.; Humble, Stewart W.; Frankenfield, Ashley M.; Li, Haorong; Prestil, Ryan; Johnson, Kory R.; Ryan, Brent J.; Wade-Martins, Richard; Ward, Michael E.; Hao, Ling 分享 收藏
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Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models Williamson, Matthew G.; Madureira, Marta; McGuinness, William; Heon-Roberts, Rachel; Mock, Elliot D.; Naidoo, Kalina; Cramb, Kaitlyn M. L.; Caiazza, Maria-Claudia; Malpartida, Ana B.; Lavelle, Martha; Savory, Katrina; Humble, Stewart W.; Patterson, Ryan; Davis, John B.; Connor-Robson, Natalie; Ryan, Brent J.; Wade-Martins, Richard 分享 收藏
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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons Bogetofte, Helle; Ryan, Brent J.; Jensen, Pia; Schmidt, Sissel I.; Vergoossen, Dana L. E.; Barnkob, Mike B.; Kiani, Lisa N.; Chughtai, Uroosa; Heon-Roberts, Rachel; Caiazza, Maria Claudia; McGuinness, William; Marquez-Gomez, Ricardo; Vowles, Jane; Bunn, Fiona S.; Brandes, Janine; Kilfeather, Peter; Connor, Jack P.; Fernandes, Hugo J. R.; Caffrey, Tara M.; Meyer, Morten; Cowley, Sally A.; Larsen, Martin R.; Wade-Martins, Richard 分享 收藏
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Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid Winchester, Laura; Barber, Imelda; Lawton, Michael; Ash, Jessica; Liu, Benjamine; Evetts, Samuel; Hopkins-Jones, Lucinda; Lewis, Suppalak; Bresner, Catherine; Malpartida, Ana Belen; Williams, Nigel; Gentlemen, Steve; Wade-Martins, Richard; Ryan, Brent; Holgado-Nevado, Alejo; Hu, Michele; Ben-Shlomo, Yoav; Grosset, Donald; Lovestone, Simon 分享 收藏
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability Ng, Bryan; Rowland, Helen A.; Wei, Tina; Arunasalam, Kanisa; Hayes, Emma Mee; Koychev, Ivan; Hedegaard, Anne; Ribe, Elena M.; Chan, Dennis; Chessell, Tharani; Ffytche, Dominic; Gunn, Roger N.; Kocagoncu, Ece; Lawson, Jennifer; Malhotra, Paresh A.; Ridha, Basil H.; Rowe, James B.; Thomas, Alan J.; Zamboni, Giovanna; Buckley, Noel J.; Cader, Zameel M.; Lovestone, Simon; Wade-Martins, Richard 分享 收藏
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function Carling, Phillippa J.; Ryan, Brent J.; McGuinness, William; Kataria, Shikha; Humble, Stewart W.; Milde, Stefan; Duce, James A.; Kapadia, Nirav; Zuercher, William J.; Davis, John B.; Di Daniel, Elena; Wade-Martins, Richard 分享 收藏
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