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王
王琰 (Yan Wang)
H指数:17
被引数:1,003
个人简介
"教育经历/Education 2003.9- 2008.7: 中国科学院生物物理研究所, 博士 Institute of Biophysics, Chinese Academy of Sciences. PhD 1999.9- 2003.7: 南开大学，学士 Nankai University, Bachelor’s Degree 工作经历/Professional Experience 2015.3-至今: 武汉大学生命科学学院, 教授 College of Life Sciences, Wuhan University, Professor 2008.8-2015.2：美国德克萨斯大学西南医学中心分子遗传学系&韖华德休斯医学院, 博士后 Department of Molecular Genetics, UTsouthwestern Medical Center, Howard Hughes Medical Institute, Postdoctoral 研究概述/Research Description： 高血脂是导致心脑血管疾病、脂肪联、胎岛素抵抗等各类代谢性疾病的重要危险因素。营养过剩及不良生活习惯是通发高血脂的重要原因，而不同人群对这些误因的敏感程度有很大差别，这主要是由遗传因素决定。据估算，50%以上的血脂异常可归因于遗传因素。我们实验室主要感兴趣的是揭示人群中血脂异常发生发展易感性背后的遗传与分子机制，结合生物化学、细胞生物学和实验动物模型等手段阐明其发病机制与作用原理，为代谢性疾病的诊治提供理论基础。 Dyslipidemia is a leading risk factor for cardiovascular diseases, with high prevalence both in China and worldwide. Over nutrition and a sedentary life style contribute to the dyslipidemia. However, different populations have varying susceptibility to these environmental factors, underscoring the importance of genetics. Population studies suggest that over 50% of dyslipidemia cases are caused by genetics risk factors. Our research aims to elucidate the genetic risk factors underling dyslipidemia. By employing animal models, cell biology, biochemistry, and cutting-edge technologies such as gene editing, we attempt to uncover the pathological functions of key human mutations in dyslipidemia, aiming to lay the ground for novel drug discovery. 奖励荣誉/Awards and Honors： 2019：湖北省“杰青” 2017：湖北省“百人计划”青年学者 2016：武汉大学“猜理”特聘教授 2013: Early career investigator award of excellence in Kern Lipid Conference 2011: Early career investigator award of excellence in Kern Lipid Conference"
教育背景
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工作经历
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荣誉奖项
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从表面到溢出：甲型H3N8流感病毒的持久性与间接传播
Microorganisms
IF4.2
老化微塑料通过破坏铜稳态诱导血管毒性：基于体内和人类血管类器官的体外研究
低剂量微/纳米塑料混合物诱导的心脏肥大和还原应激：肝-心相互作用及肝-心类器官芯片
NEUROLOGY
IF8.5
Μ 阿片受体对mTOR活性的调节取决于受体和FK506-Binding蛋白12的结合
2-(环丙烷磺酰氨基)-N-(2-乙氧基苯基) 苯甲酰胺的发现和表征，ML382: MrgX1的有效和选择性正变构调节剂
CHEMMEDCHEM
IF3.4
