Radislav Sedláček - Publications, H-index & Citations

Radislav Sedláček

Czech Academy of Sciences

37H指数

276论文数

5.1K被引数

收录论文 122

发表时间

De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity 新发EHMT2基因变异通过丧失G9a甲基转移酶活性导致常染色体显性遗传的EHMT2相关Kleefstra综合征

Nature Communications

IF15.7

2026-07-01

OAAI

Aleš Hnízda; Beatriz Martinez-Delgado; Diana Sanchez-Ponce; Javier Alonso; Jeanne Amiel; Tania Attie-Bitach; Ariadna Bada-Navarro; Beatriz Baladron; Eva Bermejo-Sanchez; Vítězslav Brinsa; Ivana Buková; Rosario Cazorla-Calleja; Sylvie Červenková; Shanshan Chow; Petr Dušek; Olha Fedosieieva; Marta Fernandez-Prieto; Sourav Ghosh; Gema Gomez-Mariano; Andrea Gřegořová; Mark James Hamilton; Hana Hartmannová; Esther Hernandez-SanMiguel; Marina Herrero-Matesanz; Kateřina Hodaňová; Alan Kádek; Jennifer Kerkhof; Tjitske Kleefstra; Didier Lacombe; Michael A. Levy; Estrella Lopez-Martin; Ruaud Lyse; Petr Man; Purificacion Marin-Reina; Ellen F. Macnamara; Haley McConkey; Petra Melenovská; Lidia M. Mielu; David Moore; Lenka Steiner Mrázová; Karolína Musilová; Kristýna Neffeová; Petr Nickl; David Pajuelo Reguera; Martina Pavlíková; Lea Pavlovičová; Manuel Posada; Jan Procházka; Kateryna Pysanenko; Sheila Ramos del Saz; Dmitrijs Rots; Jessica Rzasa; Radislav Sedláček; Viktor Stránecký; František Špoutil; Matthew L. Tedder; Louise Thompson; Cynthia J. Tifft; Frederic Tran Mau-Them; Helena Trešlová; Antonio Vitobello; Sarah Hilton; Christopher Campbell; Siddharth Banka; Daniel Jirák; Bekim Sadikovic; Jakub Sikora; Stanislav Kmoch; Maria J. Barrero; Lenka Nosková

Rationally Modified SARS-CoV-2 Spike Protein Impairs ACE2 Binding While Preserving Immunogenicity in Mice 理性修饰的SARS-CoV-2刺突蛋白在破坏ACE2结合的同时保留了小鼠的免疫原性

Vaccines

IF3.4

2026-06-28

OAAI

Elia Tamagnini; Luca Simonelli; Martin Palus; Tanja Rezzonico Jost; Edoardo Lazzarini; Davide Mangani; Václav Hönig; Markéta Dvořáková; Dominik Arbon; Federica Gambini; Sara Lestani; Fabio Grassi; Lucio Barile; Mattia Pedotti; Radislav Sedlacek; Luca Varani

Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-CYP3A4/3A7-humanized mice 孕烷X受体拮抗剂MI-891可降低PXR-CAR-CYP3A4/3A7人源化小鼠的肝脏甘油三酯水平。

Biomedicine & Pharmacotherapy

IF7.5

2026-03-05

OAAI

Klára Dohnalová; Rajamanikkam Kamaraj; Martin Ambrož; Kryštof Klíma; Karel Chalupský; Mária Bajnoková; Ivana Mejdrová; Kryštof Škach; Jana Hricová; Hana Laštůvková; Lucie Smutná; Dharani Sai Sreekanth Nellore; Radislav Sedláček; Stanislav Mičuda; Radim Nencka; Petr Pavek

Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway Rps19R67 ∆ 突变创建了Diamond-Blackfan贫血模型，并揭示了p53通路的下游介质

HemaSphere

IF14.6

2026-01-19

OAAI

Juraj Kokavec; Tereza Turková; Björn Schuster; Jan Prochazka; František Spoutil; Kristína Jamrichová; Markéta Holečková; Karel Chalupský; Inken M. Beck; Jesús Ruberte; Matilde Vale; Lukáš Čermák; Tomáš Stopka; Radislav Sedlacek

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization

European Journal of Immunology

IF3.7

2026-01-16

OAAI

Betul Melike Ogan; Veronika Forstlova; Laura Jane Dowling; Michaela Simova; Kristina Vicikova; Vendula Novosadova; Frantisek Spoutil; Sylvie Cervenkova; Michaela Procházková; Jolana Tureckova; Olha Fedosieieva; Juraj Labaj; Petr Nickl; Kamila Krizova; Jan Prochazka; Jana Balounova; Radislav Sedlacek

Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance Claudin 1介导的DC1向mTECs的定位对于维持中枢耐受至关重要

Journal of Experimental Medicine

IF10.6

2026-01-02

PREAI

Brezina, Jiri; Brabec, Tomas; Machac, David; Voboril, Matous; Ballek, Ondrej; Paces, Jan; Sykora, Vojtech; Jancovicova, Kristina; Valter, Evgeny; Kovacova, Katarina; Manning, Jasper; Tahtahova, Valerie; Cepkova, Adela; Dobesova, Martina; Dobes, Jan; Kubovciak, Jan; Kolar, Michal; Kasparek, Petr; Sedlacek, Radislav; Stepanek, Ondrej; Cerny, Jan; Tsukita, Sachiko; Malissen, Bernard; Anderson, Graham; Filipp, Dominik

Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age

FRONTIERS IN CARDIOVASCULAR MEDICINE

IF2.9

2025-12-19

OAAI

Oestereicher, Manuela A.; Ward, Christopher S.; Schneltzer, Elida; Marschall, Susan; Fuchs, Helmut; Gailus-Durner, Valerie; Bou About, Ghina; Selloum, Mohammed; Meziane, Hamid; Stewart, Michelle; Teboul, Lydia; Norris, Clare; Pimm, Dale; Kan, Marina; Lopez Gomez, Federico; Wilson, Robert; Monroy, Mayra; Pasha, Sheraz; Zabrodska, Eva; Prochazka, Jan; Pajuelo Reguera, David; Nichtova, Zuzana; Herault, Yann; Wells, Sara; Parkinson, Helen; Heaney, Jason D.; Sedlacek, Radislav; Gao, Xiang; Hrabe de Angelis, Martin; Spielmann, Nadine

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution 一种用于冻存啮齿类疾病模型的质控框架：INFRAFRONTIER在EMMA归档和分发中的质量原则

Mammalian Genome

IF2.7

2025-12-10

OAAI

Hilke Ehlich; Andrew Blease; Reva Biju; Montse Gustems; Fei Song; Sabine Fessele; Marzia Massimi; Konstantinos Bozonelos; Vasileios Ntafis; Anniina E. Hiltunen; Susan Marschall; Claudia Stoeger; Zuzana Khorshidi; Abdelmalek Ziadi; Karine Jambou; Arsenio Armagno; Ferdinando Scavizzi; Marcello Raspa; Julia Fernandez; María Jesús del Hierro; Abdelkader Ayadi; Joelle Pensavalle; Géraldine Prevost; Lucie Dufková; Michaela Krupkova; Petr Nickl; Paul Krimpenfort; Marieke van de Ven; Jos Jonkers; Gema Valera Vázquez; Michael Raess; Johannes Beckers; Anna Moles; Maik Dahlhoff; Lluis Montoliu; Yann Hérault; Reetta Hinttala; Dimitris L. Kontoyiannis; Radislav Sedlacek; Martin Hrabě de Angelis; Auke A. Boersma; Rafaele Matteoni

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation 再生的肝脏利用氨来支持从头嘧啶合成和细胞增殖

Nature Communications

IF15.7

2025-11-04

OAAI

Berwini B. Endaya; Lukáš Kučera; Dan-Diem Thi Le; Jessica B. Spinelli; Andrea Brožková; Dominika Luptáková; Kryštof Klíma; Gabriela L. Oliveira; Petra Brisudová; Klára Boháčová; Štěpána Boukalová; Renata Zobalová; František Kolář; Karel Chalupsky; Klára Dohnalová; Arash Yarmohammadi-Barzegar; Šárka Dvořáková; Evgeniya Biryukova; Marta Kaliaeva; Vladimír Havlíček; Radislav Sedláček; Jan Procházka; Libor Vítek; Sunghyouk Park; Pavel Martásek; Zdeněk Krška; Paulo J. Oliveira; Michael V. Berridge; Jiří Neužil

A consensus guide to preclinical indirect calorimetry experiments 临床前间接测热法实验的共识指南

Nature Metabolism

IF20.8

2025-09-24

PREAI

Alexander S. Banks; David B. Allison; Thierry Alquier; Ansarullah; Steven N. Austad; Johan Auwerx; Julio E. Ayala; Joseph A. Baur; Stefania Carobbio; Gary A. Churchill; Morten Dall; Rafael de Cabo; Jose Donato; Nathalia R. V. Dragano; Carol F. Elias; Anthony W. Ferrante; Brian N. Finck; Jose E. Galgani; Zachary Gerhart-Hines; Laurie J. Goodyear; Justin L. Grobe; Rana K. Gupta; Kirk M. Habegger; Sean M. Hartig; Andrea L. Hevener; Steven B. Heymsfield; Corey D. Holman; Martin Hrabě de Angelis; David E. James; Lawrence Kazak; Jae Bum Kim; Martin Klingenspor; Xingxing Kong; Sander Kooijman; Louise Lantier; K. C. Kent Lloyd; James C. Lo; Irfan J. Lodhi; Paul S. MacLean; Owen P. McGuinness; Gema Medina-Gómez; Raghavendra G. Mirmira; Christopher D. Morrison; Gregory J. Morton; Timo D. Müller; Yoshihiro Ogawa; David Pajuelo-Reguera; Matthew J. Potthoff; Nathan Qi; Marc L. Reitman; Patrick C. N. Rensen; Jan Rozman; Jennifer M. Rutkowsky; Kei Sakamoto; Philipp E. Scherer; Gary J. Schwartz; Radislav Sedlacek; Mohammed Selloum; Saame Raza Shaikh; Shuai Chen; Gerald I. Shulman; Vojtěch Škop; Alexander A. Soukas; John R. Speakman; Bruce M. Spiegelman; Gregory R. Steinberg; Katrin J. Svensson; John P. Thyfault; Tony Tiganis; Paul M. Titchenell; Nigel Turner; Licio A. Velloso; Antonio Vidal-Puig; Christopher S. Ward; Ashley S. Williams; Christian Wolfrum; Allison W. Xu; Ying Xu; Juleen R. Zierath

YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition YTHDF蛋白和m6A-RNA客户在接触抑制期间经历自噬性降解。

Cell Reports

IF6.9

2025-08-23

PREAI

Hung Ho-Xuan; Astrid Bruckmann; Lautaro Natali; Cristian Prieto-Garcia; Jan F.M. Stuke; Lorene Brunello; Alexandre Vicente; Alexander Pfab; Hagen Wesseling; Sara Cano-Franco; Anshu Khatri; Simone Larivera; Pablo Sanz-Martinez; Benjamin de la Cruz-Thea; Anne-Claire Jacomin; Jan Prochazka; Regina Feederle; Volker Dötsch; Radislav Sedlacek; Gerhard Hummer; Stefanie Kaiser; Ivan Dikic; Melina M. Musri; Gunter Meister; Alexandra Stolz

Functional mitochondrial respiration is essential for glioblastoma tumour growth 功能性线粒体呼吸对于胶质母细胞瘤肿瘤生长至关重要。

ONCOGENE

IF7.3

2025-05-05

OAAI

Brisudova, Petra; Stojanovic, Dana; Novak, Jaromir; Nahacka, Zuzana; Oliveira, Gabriela Lopes; Vanatko, Ondrej; Dvorakova, Sarka; Endaya, Berwini; Truksa, Jaroslav; Kubiskova, Monika; Foltynova, Alice; Jirak, Daniel; Jirat-Ziolkowska, Natalia; Kucera, Lukas; Chalupsky, Karel; Klima, Krystof; Prochazka, Jan; Sedlacek, Radislav; Mengarelli, Francesco; Orlando, Patrick; Tiano, Luca; Oliveira, Paulo; Grasso, Carole; Berridge, Michael V.; Zobalova, Renata; Anderova, Miroslava; Neuzil, Jiri

Characterisation of SLC38A8 and Its Role in Retinal Pathways and Disease

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

IF5.6

2025-02-16

PREAI

Weiner, Chen; Hecht, Idan; Lindovsky, Jiri; Palkova, Marcela; Krupkova, Michaela; Kasparek, Petr; Prochazka, Jan; Sedlacek, Radislav; Kotlyar, Alina; Raini, Nir; Zehavi, Yonathan; Yegorov, Yevgeni; Hilman, Pnina; Basel, Ranin; Abu-Hamed, Ramzia; Shomron, Noam; Pras, Eran

Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes 8,707敲除小鼠系的系统眼部表型鉴定与异常角膜表型相关的基因

BMC GENOMICS

IF3.7

2025-01-20

OAAI

Vo, Peter; Imai-Leonard, Denise M.; Yang, Benjamin; Briere, Andrew; Shao, Andy; Casanova, M. Isabel; Adams, David; Amano, Takanori; Amarie, Oana; Berberovic, Zorana; Bower, Lynette; Braun, Robert; Brown, Steve; Burrill, Samantha; Cho, Soo Young; Clementson-Mobbs, Sharon; D'Souza, Abigail; Dickinson, Mary; Eskandarian, Mohammad; Flenniken, Ann M.; Fuchs, Helmut; Gailus-Durner, Valerie; Heaney, Jason; Herault, Yann; de Angelis, Martin Hrabe; Hsu, Chih-Wei; Jin, Shundan; Joynson, Russell; Kang, Yeon Kyung; Kim, Haerim; Masuya, Hiroshi; Meziane, Hamid; Murray, Steve; Nam, Ki-Hoan; Noh, Hyuna; Nutter, Lauryl M. J.; Palkova, Marcela; Prochazka, Jan; Raishbrook, Miles Joseph; Riet, Fabrice; Ryan, Jennifer; Salazar, Jason; Seavey, Zachery; Seavitt, John Richard; Sedlacek, Radislav; Selloum, Mohammed; Seo, Kyoung Yul; Seong, Je Kyung; Shin, Hae-Sol; Shiroishi, Toshihiko; Stewart, Michelle; Svenson, Karen; Tamura, Masaru; Tolentino, Heather; Udensi, Uchechukwu; Wells, Sara; White, Jacqueline; Willett, Amelia; Wotton, Janine; Wurst, Wolfgang; Yoshiki, Atsushi; Int Mouse Phenotyping Consortium, Louise; Lanoue, Louise; Lloyd, K. C. Kent; Leonard, Brian C.; Roux, Michel J.; McKerlie, Colin; Moshiri, Ala

Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML

FRONTIERS IN ONCOLOGY

IF3.3

2025-01-07

OAAI

Basova, Petra; Minarik, Lubomir; Magalhaes-Novais, Silvia Carina; Balounova, Jana; Zemanova, Zuzana; Aghova, Tatiana; Spacek, Martin; Jonasova, Anna; Pimkova, Kristyna Gloc; Prochazka, Jan; Sedlacek, Radislav; Stopka, Tomas

Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2024-10-18

OAAI

Rico-Llanos, Gustavo; Spoutil, Frantisek; Blahova, Eva; Koudelka, Adolf; Prochazkova, Michaela; Czyrek, Aleksandra; Fafilek, Bohumil; Prochazka, Jan; Lopez, Marcos Gonzalez; Krivanek, Jan; Sedlacek, Radislav; Krakow, Deborah; Nonaka, Yosuke; Nakamura, Yoshikazu; Krejci, Pavel

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

SCIENTIFIC REPORTS

IF3.9

2024-09-30

OAAI

Elrick, Hillary; Peterson, Kevin A.; Willis, Brandon J.; Lanza, Denise G.; Acar, Elif F.; Ryder, Edward J.; Teboul, Lydia; Kasparek, Petr; Birling, Marie-Christine; Adams, David J.; Bradley, Allan; Braun, Robert E.; Brown, Steve D.; Caulder, Adam; Codner, Gemma F.; Demayo, Francesco J.; Dickinson, Mary E.; Doe, Brendan; Duddy, Graham; Gertsenstein, Marina; Goodwin, Leslie O.; Herault, Yann; Lintott, Lauri G.; Lloyd, K. C. Kent; Lorenzo, Isabel; Mackenzie, Matthew; Mallon, Ann-Marie; Mckerlie, Colin; Parkinson, Helen; Ramirez-Solis, Ramiro; Seavitt, John R.; Sedlacek, Radislav; Skarnes, William C.; Smedley, Damien; Wells, Sara; White, Jacqueline K.; Wood, Joshua A.; Akhtar, Shaheen; Allan, Alasdair J.; Allen, Susan; Andre, Philippe; Archer, Daniel; Atkins, Sarah; Avery, Ruth; Ayadi, Abdel; Barrett, Daniel; Beyetinova, Tanya; Bell, Toni; Berry, Melissa; Boroviak, Katharina; Bottomley, Joanna; Brendler-Spaeth, Tim; Brown, Ellen; Burvill, Jonathan; Bussell, James; Cardeno, Charis; Carter, Rebecca V.; Castellanos-Penton, Patricia; Christou, Skevoulla; Clark, Greg; Clarke, Shannon; Cleak, James; Crawford, Ronnie; Creighton, Amie; Cruz, Maribelle; Danisment, Ozge; Davis, Charlotte; Doran, Joanne; Erbs, Valerie; Fan-Lan, Qing; Fell, Rachel; Feng, He; Fougerolle, Jean-Victor; Fower, Alex; Frake, Gemma; Fray, Martin D.; Galli, Antonella; Gannon, David; Gardiner, Wendy J.; Gaspero, Angelina; Gleeson, Diane; Godbehere, Chris; Grau, Evelyn; Griffiths, Mark; Griggs, Nicola; Grimsrud, Kristin; Hazeltine, Sarah; Hutchison, Marie; Ingle, Catherine; Iyer, Vivek; Jager, Kayla; Joeng, Joanna; Kales, Susan; Kaur, Perminder; Kenyon, Janet; Kopkanova, Jana; Kujath, Christelle; Kundi, Helen; Kutny, Peter; Laurin, Valerie; Lejeay, Sandrine; Lelliott, Christopher; Loeffler, Jorik; Lorentz, Romain; Mccabe, Christopher V.; Malzer, Elke; Matthews, Peter; Maswood, Ryea; Mckay, Matthew; Meehan, Terrence; Melvin, David; Murphy, Alison; Nakhuda, Asif; Patel, Amit; Paulavets, Ilya; Pavlovic, Guillaume; Pawelka, Ashley; Pike, Fran J.; Platte, Radka; Price, Peter D.; Rajaya, Kiran; Reddy, Shalini; Rich, Whitney; Rosen, Barry; Ross, Victoria; Ruhe, Mark; Santos, Luis; Schaeffer, Laurence; Schwiening, Alix; Selloum, Mohammed; Sethi, Debarati; Sidiangco, Jan R.; Sinclair, Caroline; Sins, Elodie; Sleep, Gillian; Sorg, Tania; Starbuck, Becky; Stewart, Michelle; Swash, Holly; Thomas, Mark; Tondat, Sandra; Urban, Rachel; Urbanova, Jana; Varley, Susan; Von Schiller, Dominque; Wardle-Jones, Hannah; Weavers, Lauren; Woods, Michael; Murray, Stephen A.; Heaney, Jason D.; Nutter, Lauryl M. J.

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

NATURE COMMUNICATIONS

IF15.7

2024-08-12

OAAI

Aich, Abhishek; Boshnakovska, Angela; Witte, Steffen; Gall, Tanja; Unthan-Fechner, Kerstin; Yousefi, Roya; Chowdhury, Arpita; Dahal, Drishan; Methi, Aditi; Kaufmann, Svenja; Silbern, Ivan; Prochazka, Jan; Nichtova, Zuzana; Palkova, Marcela; Raishbrook, Miles; Koubkova, Gizela; Sedlacek, Radislav; Troeder, Simon E.; Zevnik, Branko; Riedel, Dietmar; Michanski, Susann; Moebius, Wiebke; Stroebel, Philipp; Luechtenborg, Christian; Giavalisco, Patrick; Urlaub, Henning; Fischer, Andre; Bruegger, Britta; Jakobs, Stefan; Rehling, Peter

Genetic background affects neutrophil activity and determines the severity of autoinflammatory osteomyelitis in mice

JOURNAL OF LEUKOCYTE BIOLOGY

IF3.1

2024-08-09

PREAI

Pavliuchenko, Nataliia; Kuzmina, Maria; Danek, Petr; Spoutil, Frantisek; Prochazka, Jan; Skopcova, Tereza; Pokorna, Jana; Sedlacek, Radislav; Alberich-Jorda, Meritxell; Brdicka, Tomas

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

CELL REPORTS

IF6.9

2024-08-01

OAAI

Sinigaglia, Ketty; Cherian, Anna; Du, Qiupei; Lacovich, Valentina; Vukic, Dragana; Melicherova, Janka; Linhartova, Pavla; Zerad, Lisa; Stejskal, Stanislav; Malik, Radek; Prochazka, Jan; Bondurand, Nadege; Sedlacek, Radislav; O'Connell, Mary A.; Keegan, Liam P.

研究方向