Deniz Kirik - Publications, H-index & Citations

Deniz Kirik

aligning science across parkinson's (asap) collaborative research network

70H指数

239论文数

2.0W被引数

收录论文 96

发表时间

Transgenic A53T Mice Have Astrocytic α-Synuclein Aggregates in Dopamine and Striatal Regions 转基因A53T小鼠在多巴胺能和纹状体区域存在星形胶质细胞α-突触核蛋白聚集物

Neuropathology and Applied Neurobiology

IF3.4

2026-09-07

OAAI

Cormac Peat; Asheeta Prasad; David I. Finkelstein; Caroline Sue; Jennifer A. Johnston; Clare L. Parish; Lachlan Thompson; Deniz Kirik; Glenda M. Halliday

Neurodevelopmental Alterations in Inhibitory Interneurons of Cortex, Hippocampus, and Striatum of Genetic Absence Epilepsy Rats 遗传性失神癫痫大鼠皮层、海马和纹状体中抑制性中间神经元的神经发育改变

CNS Neuroscience & Therapeutics

IF5

2026-09-04

OAAI

Nihan Çarçak; Elif Tuğçe Erdeve; Courtney J. Wright; Elif Keskinöz; My Andersson; Filiz Onat; Deniz Kırık

Machine learning image analysis predicts Parkinson disease genotype and mitochondrial lysosomal abnormalities in iPS neurons 机器学习图像分析预测帕金森病基因型和iPS神经元中线粒体溶酶体异常

npj Parkinsons Disease

IF8.2

2026-08-01

OAAI

Yan Li; Maximilian Powell; Jessica Chedid; Ratneswary Sutharsan; Adahir Labrador-Garrido; Dad Abu-Bonsrah; Chiara Pavan; Tyra Fraser; Dmitry Ovchinnikov; Melanie Zhong; Ryan Davis; Dario Strbenac; Jennifer A. Johnston; Lachlan H. Thompson; Deniz Kirik; Clare L. Parish; Glenda M. Halliday; Carolyn M. Sue; Nicolas Dzamko; Gautam Wali

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease DNA/RNA自噬蛋白SIDT2作为亨廷顿病中一种新型的神经病理学标志物

Brain Pathology

IF6.2

2026-02-24

OAAI

Sanaz Gabery; Sofia Bergh; Chrisovalantou Huridou; Rachel Y. Cheong; Barbara Baldo; Paul Günther Scheunemann; Marie-Louisa Schoebel; Linda Holmquist Mengelbier; Elisabet Englund; Catriona McLean; Carsten Saft; Deniz Kirik; Maria Björkqvist; Glenda Halliday; Elisabeth Petrasch-Parwez; Huu Phuc Nguyen; Jonasz Jeremiasz Weber; Åsa Petersén

Zero-length crosslinking: A breakthrough approach for evaluating target engagement in a-synuclein immunotherapy

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-01-01

PREAI

Rochet, Jean-Christophe; Qi, Wenzhu; Kirik, Deniz

Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain

NPJ PARKINSONS DISEASE

IF8.2

2024-11-08

OAAI

Trist, Benjamin Guy; Wright, Courtney Jade; Rangel, Alejandra; Cottle, Louise; Prasad, Asheeta; Jensen, Nanna Moller; Gram, Hjalte; Dzamko, Nicolas; Jensen, Poul Henning; Kirik, Deniz

State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons

BIOLOGY-BASEL

IF3.5

2024-09-03

OAAI

Basso, Valentina; Doebroessy, Mate D.; Thompson, Lachlan H.; Kirik, Deniz; Fuller, Heidi R.; Gates, Monte A.

Basal activity of PINK1 and PRKN in cell models and rodent brain

AUTOPHAGY

IF14.3

2023-12-02

OAAI

Watzlawik, Jens O.; Fiesel, Fabienne C.; Fiorino, Gabriella; Bustillos, Bernardo A.; Baninameh, Zahra; Markham, Briana N.; Hou, Xu; Hayes, Caleb S.; Bredenberg, Jenny M.; Kurchaba, Nicholas W.; Fricova, Dominika; Siuda, Joanna; Wszolek, Zbigniew K.; Noda, Sachiko; Sato, Shigeto; Hattori, Nobutaka; Prasad, Asheeta A.; Kirik, Deniz; Fox, Howard S.; Stauch, Kelly L.; Goldberg, Matthew S.; Springer, Wolfdieter

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease

SCIENTIFIC REPORTS

IF3.9

2023-10-18

OAAI

Sastre, Danuta; Zafar, Faria; Torres, C. Alejandra Morato; Piper, Desiree; Kirik, Deniz; Sanders, Laurie H.; Qi, L. Stanley; Schule, Birgitt

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

IF3.4

2023-03-05

OAAI

Bergh, Sofia; Gabery, Sanaz; Tonetto, Simone; Kirik, Deniz; Petersen, Asa; Cheong, Rachel Y.

Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation

PNAS NEXUS

IF3.8

2022-11-16

OAAI

Reimer, Lasse; Gram, Hjalte; Jensen, Nanna Moller; Betzer, Cristine; Yang, Li; Jin, Lorrain; Shi, Min; Boudeffa, Driss; Fusco, Giuliana; De Simone, Alfonso; Kirik, Deniz; Lashuel, Hilal A.; Zhang, Jing; Jensen, Poul Henning

Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-09-26

OAAI

Marciano, Sabina; Ionescu, Tudor M.; Saw, Ran Sing; Cheong, Rachel Y.; Kirik, Deniz; Maurer, Andreas; Pichler, Bernd J.; Herfert, Kristina

A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

CELL STEM CELL

IF20.4

2022-03-01

OAAI

Moriarty, Niamh; Gantner, Carlos W.; Hunt, Cameron P. J.; Ermine, Charlotte M.; Frausin, Stefano; Viventi, Serena; Ovchinnikov, Dmitry A.; Kirik, Deniz; Parish, Clare L.; Thompson, Lachlan H.

Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2022-02-01

PREAI

Tugba, Eryigit Karamahmutoglu; Medine, Gulcebi Idriz Oglu; Ozlem, Akman; Deniz, Kirik; Filiz, Onat Yilmaz

DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease

NEUROBIOLOGY OF DISEASE

IF5.6

2021-10-01

OAAI

Arkan, Sertan; Ljungberg, Marten; Kirik, Deniz; Hansen, Christian

Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease

MOVEMENT DISORDERS

IF7.6

2021-04-26

PREAI

Huynh, Benjamin; Fu, Yuhong; Kirik, Deniz; Shine, James M.; Halliday, Glenda M.

Positive symptom phenotypes appear progressively in EDiPS, a new animal model of the schizophrenia prodrome

SCIENTIFIC REPORTS

IF3.9

2021-02-22

OAAI

Petty, Alice; Cui, Xiaoying; Ali, Asad; Du, Zilong; Srivastav, Sunil; Kesby, James P.; Kirik, Deniz; Howes, Oliver; Eyles, Darryl

Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

IF3.4

2021-01-12

OAAI

Cheong, Rachel Y.; Baldo, Barbara; Sajjad, Muhammad U.; Kirik, Deniz; Petersen, Asa

Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease

NEUROBIOLOGY OF DISEASE

IF5.6

2021-01-01

OAAI

Marmion, David J.; Rutkowski, Angela A.; Chatterjee, Diptaman; Hiller, Benjamin M.; Werner, Milton H.; Bezard, Erwan; Kirik, Deniz; McCown, Thomas; Gray, Steven J.; Kordower, Jeffrey H.

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

MOLECULAR NEURODEGENERATION

IF17.5

2020-09-08

OAAI

Landeck, Natalie; Strathearn, Katherine E.; Ysselstein, Daniel; Buck, Kerstin; Dutta, Sayan; Banerjee, Siddhartha; Lv, Zhengjian; Hulleman, John D.; Hindupur, Jagadish; Lin, Li-Kai; Padalkar, Sonal; Stanciu, Lia A.; Lyubchenko, Yuri L.; Kirik, Deniz; Rochet, Jean-Christophe

研究方向