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Sarah Nickels

Luxembourg Centre for Systems Biomedicine

17H指数
42论文数
1.3K被引数
收录论文 17
发表时间
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Single-cell analysis reveals shared and distinct molecular signatures in brain organoid models of neurodegeneration and neuroinflammation单细胞分析揭示了神经退行性与神经炎症脑类器官模型中共享和独特的分子特征
errAlzheimer's Research & Therapy
IF7.6
err2025-11-29
err0
errOAAI
errSophie Le Bars; Mohamed Soudy; Sarah Louise Nickels; Jens Christian Schwamborn; Enrico Glaab
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err收藏
The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration帕金森病相关的LRRK2-G2019S变异限制了丝氨酸代谢，导致小胶质细胞炎症和多巴胺能神经元退变。
errJournal of Neuroinflammation
IF10.1
err2025-10-29
err0
errOAAI
errHenry Kurniawan; Sarah L. Nickels; Alise Zagare; Elisa Zuccoli; Isabel Rosety; Gemma Gomez-Giro; Enrico Glaab; Jens C. Schwamborn
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Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modeling帕金森病患者特异性中脑类器官数据在体外疾病建模中的可重复性
erriScience
IF4.1
err2025-09-10
err0
errOAAI
errElisa Zuccoli; Haya Al Sawaf; Mona Tuzza; Sarah L. Nickels; Alise Zagare; Jens C. Schwamborn
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Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling
errTISSUE BARRIERS
IF4
err2024-02-12
err5
errOAAI
errNguyen, Hoang-Tuan; Rissanen, Siiri-Liisa; Peltokangas, Mimosa; Laakkonen, Tino; Kettunen, Jere; Barthod, Lara; Sivakumar, Ragul; Palojarvi, Anniina; Junttila, Pauliina; Talvitie, Jussi; Bassis, Michele; Nickels, Sarah L.; Kalvala, Sara; Ilina, Polina; Tammela, Paivi; Lehtonen, Sarka; Schwamborn, Jens C.; Mosser, Sebastien; Singh, Prateek
err分享
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Impaired neuron differentiation in GBA-associated Parkinson's disease is linked to cell cycle defects in organoids
errNPJ PARKINSONS DISEASE
IF8.2
err2023-12-18
err7
errOAAI
errRosety, Isabel; Zagare, Alise; Saraiva, Claudia; Nickels, Sarah; Antony, Paul; Almeida, Catarina; Glaab, Enrico; Halder, Rashi; Velychko, Sergiy; Rauen, Thomas; Schoeler, Hans R.; Bolognin, Silvia; Sauter, Thomas; Jarazo, Javier; Kruger, Rejko; Schwamborn, Jens C.
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Omics data integration suggests a potential idiopathic Parkinson's disease signature
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-11-20
err7
errOAAI
errZagare, Alise; Preciat, German; Nickels, Sarah. L.; Luo, Xi; Monzel, Anna S.; Gomez-Giro, Gemma; Robertson, Graham; Jaeger, Christian; Sharif, Jafar; Koseki, Haruhiko; Diederich, Nico J.; Glaab, Enrico; Fleming, Ronan M. T.; Schwamborn, Jens C.
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Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration
errCELLS
IF5.2
err2023-11-02
err5
errOAAI
errMendes-Pinheiro, Barbara; Campos, Jonas; Marote, Ana; Soares-Cunha, Carina; Nickels, Sarah L.; Monzel, Anna S.; Cibrao, Jorge R.; Loureiro-Campos, Eduardo; Serra, Sofia C.; Barata-Antunes, Sandra; Duarte-Silva, Sara; Pinto, Luisa; Schwamborn, Jens C.; Salgado, Antonio J.
err分享
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Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
errGLIA
IF5.1
err2022-03-09
err83
errOAAI
errSabate-Soler, Sonia; Nickels, Sarah Louise; Saraiva, Claudia; Berger, Emanuel; Dubonyte, Ugne; Barmpa, Kyriaki; Lan, Yan Jun; Kouno, Tsukasa; Jarazo, Javier; Robertson, Graham; Sharif, Jafar; Koseki, Haruhiko; Thome, Christian; Shin, Jay W.; Cowley, Sally A.; Schwamborn, Jens C.
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Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2022-02-01
err34
errOAAI
errZagare, Alise; Barmpa, Kyriaki; Smajic, Semra; Smits, Lisa M.; Grzyb, Kamil; Grunewald, Anne; Skupin, Alexander; Nickels, Sarah L.; Schwamborn, Jens C.
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The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
errCELL REPORTS
IF6.9
err2021-10-01
err26
errOAAI
errWalter, Jonas; Bolognin, Silvia; Poovathingal, Suresh K.; Magni, Stefano; Gerard, Deborah; Antony, Paul M. A.; Nickels, Sarah L.; Salamanca, Luis; Berger, Emanuel; Smits, Lisa M.; Grzyb, Kamil; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobing; Ohnmacht, Jochen; Bertacchi, Michele; Jarazo, Javier; Ignac, Tomasz; Monzel, Anna S.; Gonzalez-Cano, Laura; Krueger, Rejko; Sauter, Thomas; Studer, Michele; de Almeida, Luis Pereira; Tronstad, Karl J.; Sinkkonen, Lasse; Skupin, Alexander; Schwamborn, Jens C.
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Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson's disease?
errNEURAL REGENERATION RESEARCH
IF6.7
err2021-01-01
err3
errOAAI
errNickels, Sarah Louise; Schwamborn, Jens Christian
err分享
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Machine learning-assisted neurotoxicity prediction in human midbrain organoids
errPARKINSONISM & RELATED DISORDERS
IF3.4
err2020-06-01
err46
errOAAI
errMonzel, Anna S.; Hemmer, Kathrin; Kaoma, Tony; Smits, Lisa M.; Bolognin, Silvia; Lucarelli, Philippe; Rosety, Isabel; Zagare, Alise; Antony, Paul; Nickels, Sarah L.; Krueger, Rejko; Azuaje, Francisco; Schwamborn, Jens C.
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Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients
errPARKINSONISM & RELATED DISORDERS
IF3.4
err2019-10-01
err15
errOAAI
errNickels, Sarah Louise; Walter, Jonas; Bolognin, Silvia; Gerard, Deborah; Jaeger, Christian; Qing, Xiaobing; Tisserand, Johan; Jarazo, Javier; Hemmer, Kathrin; Harms, Amy; Halder, Rashi; Lucarelli, Philippe; Berger, Emanuel; Antony, Paul M. A.; Glaab, Enrico; Hankemeier, Thomas; Klein, Christine; Sauter, Thomas; Sinkkonen, Lasse; Schwamborn, Jens Christian
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Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality
errSTEM CELL REPORTS
IF5.1
err2019-05-01
err78
errOAAI
errWalter, Jonas; Bolognin, Silvia; Antony, Paul M. A.; Nickels, Sarah L.; Poovathingal, Suresh K.; Salamanca, Luis; Magni, Stefano; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobing; Jarazo, Javier; Arias-Fuenzalida, Jonathan; Ignac, Tomasz; Monzel, Anna S.; Gonzalez-Cano, Laura; de Almeida, Luis Pereira; Skupin, Alexander; Tronstad, Karl J.; Schwamborn, Jens C.
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3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
errADVANCED SCIENCE
IF14.1
err2018-11-20
err98
errOAAI
errBolognin, Silvia; Fossepre, Marie; Qing, Xiaobing; Jarazo, Javier; Scancar, Janez; Moreno, Edinson Lucumi; Nickels, Sarah L.; Wasner, Kobi; Ouzren, Nassima; Walter, Jonas; Gruenewald, Anne; Glaab, Enrico; Salamanca, Luis; Fleming, Ronan M. T.; Antony, Paul M. A.; Schwamborn, Jens C.
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FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling
errSTEM CELL REPORTS
IF5.1
err2017-11-01
err73
errOAAI
errArias-Fuenzalida, Jonathan; Jarazo, Javier; Qing, Xiaobing; Walter, Jonas; Gomez-Giro, Gemma; Nickels, Sarah Louise; Zaehres, Holm; Schoeler, Hans Robert; Schwamborn, Jens Christian
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Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia
errSCIENTIFIC REPORTS
IF3.9
err2015-11-06
err46
errOAAI
errPalm, Thomas; Bolognin, Silvia; Meiser, Johannes; Nickels, Sarah; Traeger, Claudia; Meilenbrock, Ralf-Leslie; Brockhaus, Johannes; Schreitmueller, Miriam; Missler, Markus; Schwamborn, Jens Christian
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研究方向

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合作学者
合作期刊
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H 指数: 101 · 论文数: 451
T
Thomas Hankemeier
H 指数: 77 · 论文数: 557
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