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Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning Monti, Remo; Eick, Lisa; Hudjashov, Georgi; Lall, Kristi; Kanoni, Stavroula; Wolford, Brooke N.; Wingfield, Benjamin; Pain, Oliver; Wharrie, Sophie; Jermy, Bradley; McMahon, Aoife; Hartonen, Tuomo; Heyne, Henrike; Mars, Nina; Lambert, Samuel; Hveem, Kristian; Inouye, Michael; van Heel, David A.; Magi, Reedik; Marttinen, Pekka; Ripatti, Samuli; Ganna, Andrea; Lippert, Christoph 分享 收藏
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk 用于估计按多基因风险分层的18种疾病的国家特定累积发病率的统一框架 Jermy, Bradley; Laell, Kristi; Wolford, Brooke N.; Wang, Ying; Zguro, Kristina; Cheng, Yipeng; Kanai, Masahiro; Kanoni, Stavroula; Yang, Zhiyu; Hartonen, Tuomo; Monti, Remo; Wanner, Julian; Youssef, Omar; Lippert, Christoph; van Heel, David; Okada, Yukinori; McCartney, Daniel L.; Hayward, Caroline; Marioni, Riccardo E.; Furini, Simone; Renieri, Alessandra; Martin, Alicia R.; Neale, Benjamin M.; Hveem, Kristian; Magi, Reedik; Palotie, Aarno; Heyne, Henrike; Mars, Nina; Ganna, Andrea; Ripatti, Samuli 分享 收藏
High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases Youssef, Omar; Loukola, Anu; Zidi-Mouaffak, Yossra H. S.; Tamlander, Max; Ruotsalainen, Sanni; Kilpelainen, Elina; Mars, Nina; Ripatti, Samuli; Palotie, Aarno; Donner, Kati; Carpen, Olli 分享 收藏
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Estimating Dementia Risk Using Multifactorial Prediction Models 使用多因素预测模型估计痴呆风险 Kivimaki, Mika; Livingston, Gill; Singh-Manoux, Archana; Mars, Nina; Lindbohm, Joni V.; Pentti, Jaana; Nyberg, Solja T.; Pirinen, Matti; Anderson, Emma L.; Hingorani, Aroon D.; Sipila, Pyry N. 分享 收藏
Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation Saarentaus, Elmo; Karjalainen, Juha T.; Raemoe, Joel; Kiiskinen, Tuomo S.; Havulinna, Aki; Mehtonen, Juha; Hautakangas, Heidi; Ruotsalainen, Sanni; Tamlander, Max; Mars, Nina; Toppila-Salmi, Sanna; Pirinen, Matti; Kurki, Mitja; Ripatti, Samuli; Daly, Mark; Palotie, Tuula; Makitie, Antti; Palotie, Aarno 分享 收藏
Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases 心脏代谢疾病终身用药模式的遗传预测因子 Kiiskinen, Tuomo; Helkkula, Pyry; Krebs, Kristi; Karjalainen, Juha; Saarentaus, Elmo; Mars, Nina; Lehisto, Arto; Zhou, Wei; Cordioli, Mattia; Jukarainen, Sakari; Ramo, Joel T.; Mehtonen, Juha; Veerapen, Kumar; Rasanen, Markus; Ruotsalainen, Sanni; Maasha, Mutaamba; Niiranen, Teemu; Tuomi, Tiinamaija; Salomaa, Veikko; Kurki, Mitja; Pirinen, Matti; Palotie, Aarno; Daly, Mark; Ganna, Andrea; Havulinna, Aki S.; Milani, Lili; Ripatti, Samuli 分享 收藏
Genetic analyses implicate complex links between adult testosterone levels and health and disease Leinonen, Jaakko; Mars, Nina; Lehtonen, Leevi; Ahola-Olli, Ari; Ruotsalainen, Sanni; Lehtimaki, Terho; Kahonen, Mika; Raitakari, Olli; Piltonen, Terhi; Daly, Mark; Tuomi, Tiinamaija; Ripatti, Samuli; Pirinen, Matti; Tukiainen, Taru 分享 收藏
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Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases 免疫系统范围的孟德尔随机化和三角剖分分析支持自身免疫作为导致痴呆的疾病的可修改成分 Lindbohm, Joni V.; Mars, Nina; Sipilae, Pyry N.; Singh-Manoux, Archana; Runz, Heiko; Livingston, Gill; Seshadri, Sudha; Xavier, Ramnik; Hingorani, Aroon D.; Ripatti, Samuli; Kivimaeki, Mika 分享 收藏
Genetic risk factors have a substantial impact on healthy life years 遗传风险因素对健康生命年有重大影响 Jukarainen, Sakari; Kiiskinen, Tuomo; Kuitunen, Sara; Havulinna, Aki S.; Karjalainen, Juha; Cordioli, Mattia; Ramo, Joel T.; Mars, Nina; Gen, Finn; Samocha, Kaitlin E.; Ollila, Hanna M.; Pirinen, Matti; Ganna, Andrea 分享 收藏
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis MFGE8的帧内插入和剪接位点变异与预防冠状动脉粥样硬化有关 Ruotsalainen, Sanni E.; Surakka, Ida; Mars, Nina; Karjalainen, Juha; Kurki, Mitja; Kanai, Masahiro; Krebs, Kristi; Graham, Sarah; Mishra, Pashupati P.; Mishra, Binisha H.; Sinisalo, Juha; Palta, Priit; Lehtimaki, Terho; Raitakari, Olli; Milani, Lili; Okada, Yukinori; Palotie, Aarno; Widen, Elisabeth; Daly, Mark J.; Ripatti, Samuli 分享 收藏
Genome-wide risk prediction of common diseases across ancestries in one million people 100万人祖先常见疾病的全基因组风险预测 Mars, Nina; Kerminen, Sini; Feng, Yen-Chen A.; Kanai, Masahiro; Lall, Kristi; Thomas, Laurent F.; Parolo, Pietro della Briotta; Neale, Benjamin M.; Smoller, Jordan W.; Gabrielsen, Maiken E.; Hveem, Kristian; Magi, Reedik; Matsuda, Koichi; Okada, Yukinor; Pirinen, Matti; Palotie, Aarno; Ganna, Andrea; Martin, Alicia R.; Ripatti, Samuli 分享 收藏
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