Lars Weidolf - Publications, H-index & Citations

Lars Weidolf

RWTH Aachen University Hospital

28H指数

67论文数

3.8K被引数

收录论文 18

发表时间

Early clinical drug product shelf-life setting using accelerated predictive stability and metabolite data for impurity qualification: A case study

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2024-11-01

PREAI

Ottosson, Jenny E.; Ku, Angela; Fransson, Magnus; Leandersson, Carina; Weidolf, Lars; Ludvigsson, Jufang Wu; Klarqvist, Magnus

Distribution and biotransformation of therapeutic antisense oligonucleotides and conjugates

DRUG DISCOVERY TODAY

IF7.5

2021-10-01

PREAI

Weidolf, Lars; Bjorkbom, Anders; Dahlen, Anders; Elebring, Marie; Gennemark, Peter; Holtta, Mikko; Janzen, David; Li, XueQing; Andersson, Shalini

Qualification of impurities based on metabolite data

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2020-02-01

PREAI

Weidolf, Lars; Andersson, Thomas; Bercu, Joel P.; Brink, Andreas; Glowienke, Susanne; Harvey, James; Hayes, Martin A.; Jacques, Pascale; Lu, Chuang; Manevski, Nenad; Muster, Wolfgang; Nudelman, Raphael; Ogilvie, Ron; Ottosson, Jenny; Teasdale, Andrew; Trela, Bruce

Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development (vol 23, pg 1733, 2018)

DRUG DISCOVERY TODAY

IF7.5

2019-09-01

PREAI

Andersson, Shalini; Antonsson, Madeleine; Elebring, Marie; Jansson-Lofmark, Rasmus; Weidolf, Lars

Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-07-16

PREAI

Toselli, Francesca; Fredenwall, Marlene; Svensson, Peder; Li, Xue-Qing; Johansson, Anders; Weidolf, Lars; Hayes, Martin A.

Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development

DRUG DISCOVERY TODAY

IF7.5

2018-10-01

PREAI

Andersson, Shalini; Antonsson, Madeleine; Elebring, Marie; Jansson-Lofmark, Rasmus; Weidolf, Lars

The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

ARCHIVES OF TOXICOLOGY

IF6.9

2018-08-09

OAAI

Ekdahl, Anja; Weidolf, Lars; Baginski, Matthew; Morikawa, Yoshio; Thompson, Richard A.; Wilson, Ian D.

Electrochemical generation of drug metabolites with applications in drug discovery and development

TRAC-TRENDS IN ANALYTICAL CHEMISTRY

IF12

2015-07-01

PREAI

Jurva, Ulrik; Weidolf, Lars

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2015-04-08

PREAI

Darnell, Malin; Breitholtz, Katarina; Isin, Emre M.; Jurva, Ulrik; Weidolf, Lars

Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and Interference with Lipid Metabolism

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2013-07-05

PREAI

Darnell, Malin; Weidolf, Lars

In Vitro Evaluation of Major In Vivo Drug Metabolic Pathways Using Primary Human Hepatocytes and HepaRG Cells in Suspension and a Dynamic Three-Dimensional Bioreactor System

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2012-10-01

PREAI

Darnell, Malin; Ulvestad, Maria; Ellis, Ewa; Weidolf, Lars; Andersson, Tommy B.

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-05-31

187

PREAI

Thompson, Richard A.; Isin, Emre M.; Li, Yan; Weidolf, Lars; Page, Ken; Wilson, Ian; Swallow, Steve; Middleton, Brian; Stahl, Simone; Foster, Alison J.; Dolgos, Hugues; Weaver, Richard; Kenna, J. Gerry

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2012-02-28

250

PREAI

Isin, Emre M.; Elmore, Charles S.; Nilsson, Goran N.; Thompson, Richard A.; Weidolf, Lars

Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2008-12-01

PREAI

Hagvall, Lina; Baron, Jens Malte; Borje, Anna; Weidolf, Lars; Merk, Hans; Karlberg, Ann-Therese

State-of-the-art tools for computational site of metabolism predictions: Comparative analysis, mechanistical insights, and future applications

DRUG METABOLISM REVIEWS

IF3.8

2008-10-09

109

PREAI

Afzelius, Lovisa; Arnby, Catrin Hasselgren; Broo, Anders; Carlsson, Lars; Isaksson, Christine; Jurva, Ulrik; Kjellander, Britta; Kolmodin, Karin; Nilsson, Kristina; Raubacher, Florian; Weidolf, Lars

Electrochemical generation of electrophilic drug metabolites:: Characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2008-03-25

PREAI

Jurva, Ulrik; Holmen, Anders; Gronberg, Gunnar; Masimirembwa, Collen; Weidolf, Lars

Enantiomer/enantiomer interactions between the S- and R-isomers of omeprazole in human cytochrome P450 enzymes:: Major role of CYP2C19 and CYP3A4

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2005-11-01

PREAI

Li, XQ; Weidolf, L; Simonsson, R; Andersson, TB