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J

Jason K. Yano

Takeda Pharmaceutical Company Ltd
H指数:25
被引数:4,923

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Structure-based design of a novel series of cholesterol 24-hydroxylase (CH24H) inhibitors bearing 1,3-oxazole as a heme–iron binding group

基于结构的1,3-噁唑作为血红素-铁结合基团的新型胆固醇24-羟化酶（CH24H）抑制剂系列的设计

Bioorganic & Medicinal Chemistry
IF3
2025-06-110
OA
Yoshiteru Ito; Tomoaki Hasui; Eiji Kimura; Izumi Nomura; Hiromi Fukuda; Haruhi Kamisaki Ando; Etsurou Watanabe; Jason Yano; Robert Skene; Maki Miyamoto; Tsuyoshi Ishii; Toshiya Nishi; Tatsuki Koike
Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-07-300
OAAI
Davison, Jack R.; Hadjithomas, Michalis; Romeril, Stuart P.; Choi, Yoon Jong; Bentley, Keith W.; Biggins, John B.; Chacko, Nadia; Castaldi, M. Paola; Chan, Lawrence K.; Cumming, Jared N.; Downes, Thomas D.; Eisenhauer, Eric L.; Fei, Fan; Fontaine, Benjamin M.; Endalur Gopinarayanan, Venkatesh; Gurnani, Srishti; Hecht, Audrey; Hosford, Christopher J.; Ibrahim, Ashraf; Jagels, Annika; Joubran, Camil; Kim, Ji-Nu; Lisher, John P.; Liu, Daniel D.; Lyles, James T.; Mannara, Matteo N.; Murray, Gordon J.; Musial, Emilia; Niu, Mengyao; Olivares-Amaya, Roberto; Percuoco, Marielle; Saalau, Susanne; Sharpe, Kristen; Sheahan, Anjali V.; Thevakumaran, Neroshan; Thompson, James E.; Thompson, Dawn A.; Wiest, Aric; Wyka, Stephen A.; Yano, Jason; Verdine, Gregory L.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

在RAS驱动的癌症中通过RMC-6236抑制RAS-GTP的翻译和治疗评估

CANCER DISCOVERY
IF33.3
2024-04-0931
OAAI
Jiang, Jingjing; Jiang, Lingyan; Maldonato, Benjamin J.; Wang, Yingyun; Holderfield, Matthew; Aronchik, Ida; Winters, Ian P.; Salman, Zeena; Blaj, Cristina; Menard, Marie; Brodbeck, Jens; Chen, Zhe; Wei, Xing; Rosen, Michael J.; Gindin, Yevgeniy; Lee, Bianca J.; Evans, James W.; Chang, Stephanie; Wang, Zhican; Seamon, Kyle J.; Parsons, Dylan; Cregg, James; Marquez, Abby; Tomlinson, Aidan C. A.; Yano, Jason K.; Knox, John E.; Quintana, Elsa; Aguirre, Andrew J.; Arbour, Kathryn C.; Reed, Abby; Gustafson, W. Clay; Gill, Adrian L.; Koltun, Elena S.; Wildes, David; Smith, Jacqueline A. M.; Wang, Zhengping; Singh, Mallika
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARM-s) Part Ill: Discovery of 4-(5-oxopyrrolidine-1-yl) benzonitrile derivative 2f as a clinical candidate

新型选择性雄激素受体调节剂 (SARM-s) 的合成和生物学评价第iii部分: 发现4-(5-氧代吡咯烷-1-基) 苄腈衍生物2f作为临床候选物

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2017-07-0137
PREAI
Aikawa, Katsuji; Asano, Moriteru; Ono, Koji; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Kandori, Hitoshi; Hara, Takahito; Morimoto, Megumi; Santou, Takashi; Yamaoka, Masuo; Nakayama, Masaharu; Hasuoka, Atsushi
Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2013-08-01106
PREAI
Okaniwa, Masanori; Hirose, Masaaki; Arita, Takeo; Yabuki, Masato; Nakamura, Akito; Takagi, Terufumi; Kawamoto, Tomohiro; Uchiyama, Noriko; Sumita, Akihiko; Tsutsumi, Shunichirou; Tottori, Tsuneaki; Inui, Yoshitaka; Sang, Bi-Ching; Yano, Jason; Aertgeerts, Kathleen; Yoshida, Sei; Ishikawa, Tomoyasu
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2012-09-0119
PRE
Hirose, Masaaki; Okaniwa, Masanori; Miyazaki, Tohru; Imada, Takashi; Ohashi, Tomohiro; Tanaka, Yuta; Arita, Takeo; Yabuki, Masato; Kawamoto, Tomohiro; Tsutsumi, Shunichirou; Sumita, Akihiko; Takagi, Terufumi; Sang, Bi-Ching; Yano, Jason; Aertgeerts, Kathleen; Yoshida, Sei; Ishikawa, Tomoyasu
Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-03-1473
PREAI
Okaniwa, Masanori; Hirose, Masaaki; Imada, Takashi; Ohashi, Tomohiro; Hayashi, Youko; Miyazaki, Tohru; Arita, Takeo; Yabuki, Masato; Kakoi, Kazuyo; Kato, Juran; Takagi, Terufumi; Kawamoto, Tomohiro; Yao, Shuhei; Sumita, Akihiko; Tsutsumi, Shunichirou; Tottori, Tsuneaki; Oki, Hideyuki; Sang, Bi-Ching; Yano, Jason; Aertgeerts, Kathleen; Yoshida, Sei; Ishikawa, Tomoyasu
Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2011-11-04206
PREAI
Ishikawa, Tomoyasu; Seto, Masaki; Banno, Hiroshi; Kawakita, Youichi; Oorui, Mami; Taniguchi, Takahiko; Ohta, Yoshikazu; Tamura, Toshiya; Nakayama, Akiko; Miki, Hiroshi; Kamiguchi, Hidenori; Tanaka, Toshimasa; Habuka, Noriyuki; Sogabe, Satoshi; Yano, Jason; Aertgeerts, Kathleen; Kamiyama, Keiji
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554 (vol 19, pg 4482, 2011)
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2011-09-010
OAAI
Maezaki, Hironobu; Banno, Yoshihiro; Miyamoto, Yasufumi; Moritoh, Yusuke; Asakawa, Tomoko; Kataoka, Osamu; Takeuchi, Koji; Suzuki, Nobuhiro; Ikedo, Koji; Kosaka, Takuo; Sasaki, Masako; Tsubotani, Shigetoshi; Tani, Akiyoshi; Funami, Miyuki; Yamamoto, Yoshio; Tawada, Michiko; Aertgeerts, Kathleen; Yano, Jason; Oi, Satoru
Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2011-08-0145
PRE
Banno, Yoshihiro; Miyamoto, Yasufumi; Sasaki, Mitsuru; Oi, Satoru; Asakawa, Tomoko; Kataoka, Osamu; Takeuchi, Koji; Suzuki, Nobuhiro; Ikedo, Koji; Kosaka, Takuo; Tsubotani, Shigetoshi; Tani, Akiyoshi; Funami, Miyuki; Tawada, Michiko; Yamamoto, Yoshio; Aertgeerts, Kathleen; Yano, Jason; Maezaki, Hironobu
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

发现靶向Lys554的有效，选择性和口服生物利用度的基于喹啉的二肽基肽酶IV抑制剂

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2011-08-0136
PRE
Maezaki, Hironobu; Banno, Yoshihiro; Miyamoto, Yasufumi; Moritou, Yuusuke; Asakawa, Tomoko; Kataoka, Osamu; Takeuchi, Koji; Suzuki, Nobuhiro; Ikedo, Koji; Kosaka, Takuo; Sasaki, Masako; Tsubotani, Shigetoshi; Tani, Akiyoshi; Funami, Miyuki; Yamamoto, Yoshio; Tawada, Michiko; Aertgeerts, Kathleen; Yano, Jason; Oi, Satoru
Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2011-02-2242
PREAI
Gould, Alexandra E.; Adams, Ruth; Adhikari, Sharmila; Aertgeerts, Kathleen; Afroze, Roushan; Blackburn, Christopher; Calderwood, Emily F.; Chau, Ryan; Chouitar, Jouhara; Duffey, Matthew O.; England, Dylan B.; Farrer, Cheryl; Forsyth, Nancy; Garcia, Khristofer; Gaulin, Jeffery; Greenspan, Paul D.; Guo, Ribo; Harrison, Sean J.; Huan, Shih-Chung; Iartchouk, Natalia; Janowick, Dave; Kim, Mi-Sook; Kulkarni, Bheemashankar; Langston, Steven P.; Liu, Jane X.; Ma, Li-Ting; Menon, Saurabh; Mizutani, Hirotake; Paske, Erin; Renou, Christelle C.; Rezaei, Mansoureh; Rowland, R. Scott; Sintchak, Michael D.; Smith, Michael D.; Stroud, Stephen G.; Tregay, Ming; Tian, Yuan; Veiby, Ole P.; Vos, Tricia J.; Vyskocil, Stepan; Williams, Juliet; Xu, Tianlin; Yang, Johnny J.; Yano, Jason; Zeng, Hongbo; Zhang, Dong Mei; Zhang, Qin; Galvin, Katherine M.

研究方向

暂未获取到该数据
K
Kathleen Aertgeerts
H 指数:24论文数:83被引数:3,244
E
Eric F. Johnson
H 指数:58论文数:190被引数:1.2万
T
Tomoyasu Ishikawa
H 指数:22论文数:122被引数:2,283
N
Nobuhiro Suzuki
H 指数:55论文数:243被引数:1.7万
T
Tatsuki Koike
H 指数:16论文数:61被引数:888
T
Toshiya Nishi
H 指数:14论文数:36被引数:585
Y
Yoshio Yamamoto
H 指数:44论文数:615被引数:8,451
H
Hironobu Maezaki
H 指数:14论文数:40被引数:607
K
Koji Takeuchi
H 指数:64论文数:886被引数:1.7万
A
Akiyoshi Tani
H 指数:16论文数:33被引数:844