未登录 Impact of varying lung function threshold on clinical remission in asthma with FF/UMEC/VI: CAPTAIN post hoc analysis Oppenheimer, John; Pavord, Ian; Crawford, Jodie; Gould, Stephen; Hamouda, Mohamed; Igboekwe, Emmeline; Moore, Alison; Noorduyn, Stephen G.; Slade, David; Weng, Stephen; Lugogo, Njira 分享 收藏
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors 联合PD-L1/tgf β 阻断可在免疫排除的肿瘤中扩增和分化干细胞样CD8 T细胞 Castiglioni, Alessandra; Yang, Yagai; Williams, Katherine; Gogineni, Alvin; Lane, Ryan S.; Wang, Amber W.; Shyer, Justin A.; Zhang, Zhe; Mittman, Stephanie; Gutierrez, Alan; Astarita, Jillian L.; Thai, Minh; Hung, Jeffrey; Yang, Yeqing Angela; Pourmohamad, Tony; Himmels, Patricia; De Simone, Marco; Elstrott, Justin; Capietto, Aude-Helene; Cubas, Rafael; Modrusan, Zora; Sandoval, Wendy; Ziai, James; Gould, Stephen E.; Fu, Wenxian; Wang, Yulei; Koerber, James T.; Sanjabi, Shomyseh; Mellman, Ira; Turley, Shannon J.; Mueller, Soeren 分享 收藏
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition Alicke, Bruno; Varfolomeev, Eugene; Lee, Shi Hui Kaylee; Frommlet, Alexandra; Ubhayakar, Savita; Quinn, John G.; Fairbrother, Wayne J.; Jones, Robert; Gould, Stephen E.; Vucic, Domagoj 分享 收藏
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MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity Esen, Emel; Sergin, Ismail; Jesudason, Rajiv; Himmels, Patricia; Webster, Joshua D.; Zhang, Hua; Xu, Min; Piskol, Robert; McNamara, Erin; Gould, Stephen; Capietto, Aude-Helene; Delamarre, Lelia; Walsh, Kevin; Ye, Weilan 分享 收藏
Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses Cubas, Rafael; Moskalenko, Marina; Cheung, Jeanne; Yang, Michelle; McNamara, Erin; Xiong, Huizhong; Hoves, Sabine; Ries, Carola H.; Kim, Jeong; Gould, Stephen 分享 收藏
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors Hagenbeek, Thijs J.; Webster, Joshua D.; Kljavin, Noelyn M.; Chang, Matthew T.; Trang Pham; Lee, Ho-June; Klijn, Christiaan; Cai, Allen G.; Totpal, Klara; Ravishankar, Buvana; Yang, Naiying; Lee, Da-Hye; Walsh, Kevin B.; Hatzivassiliou, Georgia; de la Cruz, Cecile C.; Gould, Stephen E.; Wu, Xiumin; Lee, Wyne P.; Yang, Shuqun; Zhang, Zhixiang; Gu, Qingyang; Ji, Qunsheng; Jackson, Erica L.; Lim, Dae-Sik; Dey, Anwesha 分享 收藏
Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats Li, Jinze; Morinello, Eric; Larsen, Thomas; Frost, Denzil; Caro, Ivor; Gould, Stephen; Wong, Lisa; Hendricks, Angela; Dybdal, Noel; Dambach, Donna; Schutten, Melissa 分享 收藏
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PRC2 mediated repression of SMARCA2 predicts for EZH2 inhibitor activity in tumors with SWI/SNF mutations Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Solon, Margaret; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Koeppen, Hartmut; Yauch, Robert L. 分享 收藏
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T cell-dependent bispecific antibody anti-CD79b/CD3 as a potential therapy for B-cell malignancies Wang, Peiyin; Hristopoulos, Maria; Clark, Robyn; Chen, Yvonne; Ellerman, Diego; Mathieu, Mary; Spiess, Christoph; Li, Jessica; Chalouni, Cecile; Sukumaran, Siddharth; Stefanich, Eric; Wallin, Jeffrey; Li, Robert; Zabka, Tanja; Totpal, Klara; Dennis, Mark; Ebens, Allen; Gould, Stephen; Polson, Andrew; Sun, Liping Laura 分享 收藏
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development Blake, James F.; Burkard, Michael; Chan, Jocelyn; Chen, Huifen; Chou, Kang-Jye; Diaz, Dolores; Dudley, Danette A.; Gaudino, John J.; Gould, Stephen E.; Grina, Jonas; Hunsaker, Thomas; Liu, Lichuan; Martinson, Matthew; Moreno, David; Mueller, Lars; Orr, Christine; Pacheco, Patricia; Qin, Ann; Rasor, Kevin; Ren, Li; Robarse, Kirk; Shahidi-Latham, Sheerin; Stults, Jeffrey; Sullivan, Francis; Wang, Weiru; Yin, Jianping; Zhou, Aihe; Belvin, Marcia; Merchant, Mark; Moffat, John; Schwarz, Jacob B. 分享 收藏
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade Ebert, Peter J. R.; Cheung, Jeanne; Yang, Yagai; McNamara, Erin; Hong, Rebecca; Moskalenko, Marina; Gould, Stephen E.; Maecker, Heather; Irving, Bryan A.; Kim, Jeong M.; Belvin, Marcia; Mellman, Ira 分享 收藏
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR Heffron, Timothy P.; Ndubaku, Chudi O.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Drobnick, Joy; Edgar, Kyle; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Nonomiya, Jim; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin; Olivero, Alan G. 分享 收藏
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis Ndubaku, Chudi O.; Crawford, Terry D.; Chen, Huifen; Boggs, Jason W.; Drobnick, Joy; Harris, Seth F.; Jesudason, Rajiv; McNamara, Erin; Nonomiya, Jim; Sambrone, Amy; Schmidt, Stephen; Smyczek, Tanya; Vitorino, Philip; Wang, Lan; Wu, Ping; Yeung, Stacey; Chen, Jinhua; Chen, Kevin; Ding, Charles Z.; Wang, Tao; Xu, Zijin; Gould, Stephen E.; Murray, Lesley J.; Ye, Weilan 分享 收藏
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Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2 Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B. 分享 收藏
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