Xiangyou Hu - Publications, H-index & Citations

Xiangyou Hu

university of connecticut

31H指数

76论文数

3.3K被引数

收录论文 36

发表时间

Prodromal changes in cortical neuron physiology before amyloid pathology in a mild model of Alzheimer’s disease 在轻度阿尔茨海默病模型中，在淀粉样蛋白病理出现之前的皮层神经元生理学前驱变化

Scientific Reports

IF3.9

2026-04-09

OAAI

Katarina D. Milicevic; Ana C. Abreu; Gowri Chandran; Yan M. D. Zhu; Xiangyou Hu; Violetta O. Ivanova; Madhav Jami; Bernd Simon; Ignacio Fernández; Riqiang Yan; Srdjan D. Antic

BACE1 Expression Is Required for Proper Synaptic Vesicle Dynamics in the Hippocampus BACE1 表达对于海马区突触囊泡的正常动力学是必需的。

JOURNAL OF NEUROCHEMISTRY

IF4

2025-11-01

OAAI

Zhou, John; Antic, Srdjan D.; Das, Brati; He, Wanxia; Tran, Dang Minh; Hu, Xiangyu; Fernandez-Chacon, Rafael; Yan, Riqiang

Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects 肌萎缩侧索硬化症和额颞叶痴呆突变降低内皮TDP-43并导致血脑屏障缺陷

SCIENCE ADVANCES

IF12.5

2025-04-18

PREAI

Cheemala, Ashok; Kimble, Amy L.; Burrage, Emily N.; Helming, Stephen B.; Tyburski, Jordan D.; Leclair, Nathan K.; Omar, Omar M.; Zuberi, Aamir R.; Murphy, Melissa; Jellison, Evan R.; Reese, Bo; Hu, Xiangyou; Lutz, Cathleen M.; Yan, Riqiang

Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer's disease 阿尔茨海默病小鼠模型中少突胶质细胞淀粉样蛋白沉积的贡献

MOLECULAR NEURODEGENERATION

IF17.5

2024-11-16

OAAI

Ishii, Akihiro; Pathoulas, Joseph A.; Omar, Omar MoustafaFathy; Ge, Yingying; Yao, Annie Y.; Pantalena, Tressa; Singh, Neeraj; Zhou, John; He, Wanxia; Murphy, Patrick; Yan, Riqiang; Hu, Xiangyou

IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus

SCIENTIFIC REPORTS

IF3.9

2024-07-16

OAAI

Menoret, Antoine; Agliano, Federica; Karginov, Timofey A.; Hu, Xiangyou; Vella, Anthony T.

Dysfunctional Bladder Morphology and Functional Impairments Are Identified in the Alzheimer's Disease APPNL-G-F/NL-G-F Murine Model 在阿尔茨海默氏病appnl-g-f/nl-g-f小鼠模型中确定了功能失调的膀胱形态和功能障碍

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2024-01-02

PREAI

Ge, Yingying; AlObaidi, Alya S.; Kuchel, George A.; Bartley, Jenna M.; Smith, Phillip P.; He, Wanxia; Hu, Xiangyou

Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development

HUMAN MOLECULAR GENETICS

IF3.2

2023-05-25

OAAI

Zhou, John; Shi, Qi; Ge, Ying Y.; He, Wanxia; Hu, Xiangyou; Xia, Weiming; Yan, Riqiang

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides BACE1调节星形胶质细胞中Clusterin的表达以增强 β-淀粉样肽的清除

MOLECULAR NEURODEGENERATION

IF17.5

2023-05-04

OAAI

Zhou, John; Singh, Neeraj; Galske, James; Hudobenko, Jacob; Hu, Xiangyou; Yan, Riqiang

Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation

HUMAN MOLECULAR GENETICS

IF3.2

2022-11-12

OAAI

Benoit, Marc R.; Darboe, Mabintou; Das, Brati; Ge, Yingying; Zhou, John; Yao, Annie; He, Wanxia; Yan, Riqiang; Hu, Xiangyou

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

SCIENCE ADVANCES

IF12.5

2022-07-22

OAAI

Singh, Neeraj; Das, Brati; Zhou, John; Hu, Xiangyou; Yan, Riqiang

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

SCIENCE ADVANCES

IF12.5

2022-06-17

OAAI

Singh, Neeraj; Benoit, Marc R.; Zhou, John; Das, Brati; Davila-Velderrain, Jose; Kellis, Ma Nolis; Tsai, Li-Huei; Hu, Xiangyou; Yan, Riqiang

BACE1 controls synaptic function through modulating release of synaptic vesicles

MOLECULAR PSYCHIATRY

IF10.1

2021-06-22

OAAI

Das, Brati; Singh, Neeraj; Yao, Annie Y.; Zhou, John; He, Wanxia; Hu, Xiangyou; Yan, Riqiang

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2019-06-17

OAAI

Fan, Qingyuan; Gayen, Manoshi; Singh, Neeraj; Gao, Fan; He, Wanxia; Hu, Xiangyou; Tsai, Li-Huei; Yan, Riqiang

Sequential formation of different layers of dystrophic neurites in Alzheimer's brains

MOLECULAR PSYCHIATRY

IF10.1

2019-03-21

OAAI

Sharoar, Md Golam; Hui, Xiangyou; Ma, Xin-Ming; Zhu, Xiongwei; Yan, Riqiang

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2018-02-14

OAAI

Hu, Xiangyou; Das, Brati; Hou, Hailong; He, Wanxia; Yan, Riqiang

RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains

SCIENTIFIC REPORTS

IF3.9

2017-07-21

OAAI

Shi, Qi; Ge, Yingying; He, Wanxia; Hu, Xiangyou; Yan, Riqiang

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

STEM CELL REPORTS

IF5.1

2017-07-01

OAAI

Hou, Hailong; Fan, Qingyuan; He, Wanxia; Suh, Hoonkyo; Hu, Xiangyou; Yan, Riqiang

BACE1 regulates the proliferation and cellular functions of Schwann cells

GLIA

IF5.1

2017-02-13

OAAI

Hu, Xiangyou; Hou, Hailong; Bastian, Chinthasagar; He, Wanxia; Qiu, Shupeng; Ge, Yingying; Yin, Xinhua; Kidd, Grahame J.; Brunet, Sylvain; Trapp, Bruce D.; Baltan, Selva; Yan, Riqiang

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease

MOLECULAR PSYCHIATRY

IF10.1

2015-12-01

OAAI

Sharoar, M. G.; Shi, Q.; Ge, Y.; He, W.; Hu, X.; Perry, G.; Zhu, X.; Yan, R.

Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

BIOLOGICAL PSYCHIATRY

IF9

2014-07-01

OAAI

Luo, Xiaoyang; He, Wanxia; Hu, Xiangyou; Yan, Riqiang

研究方向