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Q

Qin Sun

泸州医学院
H指数:42
被引数:5,484

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Targeted Degradation of Bromodomain-Containing Protein 4 Enabled by Reactive Oxygen Species-Activatable NanoPROTACs as an Efficient Strategy to Reverse Liver Fibrosis in Chronic Liver Injury

由活性氧可激活的NanoPROTACs介导的溴域蛋白4靶向降解，作为一种逆转慢性肝损伤中肝纤维化的有效策略。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-03-062
PRE
Bi, Tao; Liang, Pan; Zhao, Qixin; Wu, Jiao; Zhou, Yanan; Xu, Yunke; Fan, Xuehui; Yang, Guoqiang; Sun, Qin; Ren, Wei; Yang, Yingcheng; Liu, Zengjin
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2023-05-011
PRE
Jurica, Elizabeth A.; Wu, Ximao; Williams, Kristin N.; Haque, Lauren E.; Rampulla, Richard A.; Mathur, Arvind; Zhou, Min; Cao, Gary; Cai, Hong; Wang, Tao; Liu, Heng; Xu, Carrie; Kunselman, Lori K.; Antrilli, Thomas M.; Hicks, Michael B.; Sun, Qin; Dierks, Elizabeth A.; Apedo, Atsu; Moore, Douglas B.; Foster, Kimberly A.; Cvijic, Mary Ellen; Panemangalore, Reshma; Khandelwal, Purnima; Wilkes, Jason J.; Zinker, Bradley A.; Robertson, Donald G.; Janovitz, Evan B.; Galella, Michael; Li, Yi-Xin; Li, Julia; Ramar, Thangeswaran; Jalagam, Prasada Rao; Jayaram, Ramya; Whaley, Jean M.; Barrish, Joel C.; Robl, Jeffrey A.; Ewing, William R.; Ellsworth, Bruce A.

研究方向

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