梁

梁超 (Chao Liang)

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University副教授邮箱:liangchao@wmu.edu.cn

H指数:93

被引数:2.7万

个人简介

"研究领域骨关节相关疾病以及肿瘤的机制研究、转化医学和精准医学。教学《基因工程学》、《前沿基因工程技术与应用》学术成果查看更多 Huang J*, Fu X*#, Zhang R, Wang Z, Qiu F, Chen X, Fan J, Cao C, Yang X, Li J, Liang Y, He D#, Lu A#, Liang C#. snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice. Sci Transl Med. In press. DOI: 10.1126/scitranslmed.adt5340. Xu Y*, Xie D*, Cao C*, Wang Z*, Yue Ju, Chen X, Guan L, Li X, Zhang L#, Liang C#, Yin X#. PSMA-targeted CAR-macrophages drive glycolytic reprogramming for enhanced prostate cancer immunotherapy. J Hematol Oncol18, 95 (2025). https://doi.org/10.1186/s13045-025-01743-w. Fu X*, Yang X#, Huang J*, Huang Y*, Patrick Ryan Potts. Liang C#. A Cancer-Specific Antigen Drives Histone Acetylation by Stabilizing the Acetyltransferases. Cell Rep 44, 116408. https://doi.org/10.1016/j.celrep.2025.116408. Shan Y, Guo M, Liu J, Wang L, Shen Y, Zhao J, Wei K, Jiang P, Shi Y, Chang C, Zheng Y, Zhao F, Li Y, Zhou M, Li C, Guo S, Liang C#, Qu H#, He D#. Comparative Analysis Revealed Circulating Methylation of PDGFRB Highly Related with Rheumatoid Arthritis Related Diseases. Endocr Metab Immune Disord Drug Targets.2025 Sep 16. doi: 10.2174/0118715303377879250831134649. Epub ahead of print. PMID: 40965028. Wang Z*, Xie D*, Zhu P*, Guo J, Cao C, Du Y#, Lu A#, Liang C#. An aptamer specifically targeting mCRP ameliorates experimental arthritis. J Orthop Translat. https://doi.org/10.1016/j.jot.2025.08.010. Zhao J, Chen H*, Liang C#. Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation. Biomark Res13, 111 (2025). https://doi.org/10.1186/s40364-025-00826-7 Yue S*, Fan J*, Xie D*, Cao C, Wang Z, Huang J, Qiu F, Yang X, He D#, Lu A#, Liang C#. Unveiling the Therapeutic Potential: Targeting Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Expert Rev Mol Med. 2025 Jun 5:1-24. doi: 10.1017/erm.2025.11. Epub ahead of print. PMID: 40468839. Fu X*, Zhong C*, Liu W*, Ren F#, Liang C#. Development of Injectable Aldehyde Hyaluronic Acid Hydrogels Loaded with CRISPRa Reprogrammed Elite Macrophages for the Treatment of Osteoarthritis. ACS Appl Mater Interfaces. 2025 May 21. doi: 10.1021/acsami.5c04355. Epub ahead of print. PMID: 40397763. Huang J*, Fu X*, Qiu F*, Liang Z, Cao C, Wang Z, Chen H, Yue S, Xie D, Liang Y, Lu A#, Liang C#. Discovery of a Natural Ent-Kaurene Diterpenoid Oridonin as an E3 Ligase Recruiter for PROTACs. J Am Chem Soc. 2025 Jan 15;147(2):1920-1937. doi: 10.1021/jacs.4c14650. Qiu F*, Xie D*, Chen H, Wang Z, Huang J, Cao C, Liang Y, Yang X, He DY, Fu X#, Lu A#, Liang C#. Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis. Ann Rheum Dis.2024 Sep 4:ard-2024-225565. doi: 10.1136/ard-2024-225565. Epub ahead of print. PMID: 39237134. Du Y*,Gao X*, Chen J, Chen X, Liu H, He W, Liu L, Jiang Y, He B, Deng Z, Liang C#, Guo F#. OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis. J Orthop Translat 2025, 50, 14-29. Cao C*, Yue S, Lu A#, Liang C#. Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers. Pharmacol Res.2024 Sep;207:107321. doi: 10.1016/j.phrs.2024.107321. Epub 2024 Jul 20. PMID: 39038631. Liang C. Proximod as a potential therapy for rheumatoid arthritis. Lancet Rheumatol.2024 Oct 22:S2665-9913(24)00237-6. doi: 10.1016/S2665-9913(24)00237-6. Epub ahead of print. PMID: 39454618. Wang Z*, Yue S*, Chen X*, Li J*, Zhu P, Chen H, Qiu F, Xie D, Liang Y, Li D#, Lu A#, Liang C#. Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability. J Med Chem. 2024 Oct 22. doi: 10.1021/acs.jmedchem.4c01228. Epub ahead of print. PMID: 39437434. Feng Z*, Xie D*, Qiu F, Huang J, Wang Z, Liang C#. Development of hybrid aptamers-engineered PROTACs for degrading VEGF165 in both tumor- and vascular endothelial cells. Eur J Med Chem.2024 Nov 2;281:117027. doi: 10.1016/j.ejmech.2024.117027. Epub ahead of print. PMID: 39504794. Fu X*, Huang J*, Chen X, Xie D, Chen H, Liang Z, Wang Z, Liang Y, Lu A#, Liang C#. Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma. Theranostics 2025; 15(1):103-121. doi:10.7150/thno.99588. Xu Y*, Xie D*, Cao C*, Yue Ju, Chen X, Guan L, Li X, Zhang L#, Liang C#, Yin X#. PSMA-specific CAR-engineered macrophages for therapy of prostate cancer. bioRxiv 09.07.611792; doi: https://doi.org/10.1101/2024.09.07.611792. Li J, Liang C#. Protocol for constructing tumor-targeting ANM-PROTACs for degradation of transcription factors. STAR Protoc.2024 Sep 20;5(3):103220. doi: 10.1016/j.xpro.2024.103220. Epub 2024 Jul 27. PMID: 39068654; PMCID: PMC11339245. Chen H*, Fu X*, Wu X*, Zhao J, Qiu F, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G#, Lu A#, Liang C#. Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. Bone Res.2024 May 23;12(1):31. doi: 10.1038/s41413-024-00336-6. PMID: 38782893; PMCID: PMC11116389. Huang Y*., Wang Z*., Zhong C*., Chen H, Chen X, Cao C, Qiu F, Xie D, Li J, Li J, Yang X, Lu A#, Fu X#, Liang C#, (2024). CRISPRa engineered Elite macrophages enable adoptive cell therapy for rheumatoid arthritis. The Innovation Medicine2(1): 100050. https://doi.org/10.59717/j.xinn-med.2024.100050. Fu X*, Li J*, Chen X*, Chen H*, Wang Z, Qiu F, Xie D, Huang J, Yue S, Cao C, Liang Y, Lu A#, Liang C#.Repurposing AS1411 for constructing ANM-PROTACs. Cell Chem Biol. 2024 Apr 12:S2451-9456(24)00127-2. doi: 10.1016/j.chembiol.2024.03.011. Epub ahead of print. PMID: 38657608. Mi C#*, Zhang X*, Yang C, Wu J, Chen X, Ma C, Wu S, Yang Z, Qiao P, Liu Y, Wu W, Guo Z, Liao J, Zhou J, Guan M, Liang C#, Liu C#, Jin D#. Bone disease imaging through the near-infrared-II window. Nat Commun. 2023 Oct 9;1"

教育背景

2016.12
香港浸会大学博士

工作经历

2020.01 – 至今
南方科技大学生物系
副教授
2016.01 – 2020.12
香港浸会大学
博士后及研究助理教授

荣誉奖项

暂无内容

Refractory Bacterial Meningitis Associated with an Occult Posterior Fossa Dermal Sinus Tract in an Infant: A Case Report

婴儿隐匿性后颅窝皮样窦道相关难治性细菌性脑膜炎：病例报告

Infection and Drug Resistance

IF2.9

2026-09-140

KRAS signaling networks, mutational heterogeneity, and emerging therapeutic strategies for cancer treatment

KRAS信号网络、突变异质性及癌症治疗的新兴治疗策略

Biomarker Research

IF11.5

2026-08-110

Continuous Synthesis of Optimized Ni3(HITP)2 With Broad Spectrum of Morphologies via Automated Microfluidic Ammonia Manipulation Platform

通过自动化微流控氨气操控平台连续合成具有广泛形貌的优化Ni3(HITP)2

Small Methods

IF9.1

2026-05-290

PRE

Magnetic fluorescent carbon dots synthesized via one-pot approach for tumor photothermal therapy

通过一锅法合成的磁性荧光碳点用于肿瘤光热治疗

iScience

IF4.1

2025-12-110

OAAI

A novel gel-modified metal-coordination polymer strategy with stable anti-fouling properties for efficient emulsion separation

一种具有稳定抗污性能的新型凝胶改性金属配位聚合物策略，用于高效乳液分离

Chemical Engineering Journal

IF13.2

2025-12-080

PRE

End-to-end detection of cough and snore based on ResNet18-TF for breeder laying hens: A field study

Ma, H.; Xin, P.; Ma, J.; Yang, X.; Zhang, R.; Liang, C.; Liu, Y.; Qi, F.; Wang, C. 基于ResNet18-TF的种蛋鸡咳嗽和鼾声端到端检测：一项实地研究。Artif. Intell. Agric. 2026, 16, 412–422. [Google Scholar] [CrossRef]

ARTIFICIAL INTELLIGENCE IN AGRICULTURE

IF12.4

2025-11-011

OAAI

A Heterotrinuclear Ir(III)–Gd(III) Complex as a Mito-Bomb for Bimodal Imaging–Guided Precision Cancer Therapy

一种异三核Ir(III)–Gd(III)配合物作为线粒体炸弹，用于双模态成像引导的精准癌症治疗

Advanced Healthcare Materials

IF9.6

2025-10-200

PRE

Advances in Optical Imaging in the diagnosis of Traumatic Brain Injury

光学成像在创伤性脑损伤诊断中的进展